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maandag 5 november 2018

EMBO reports Table of Contents for November 2018; Vol. 19, No. 11

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November 2018 | Volume 19, Number 11 Submit


Table of Contents

Opinion
Science & Society
Reviews
Scientific Reports
Articles
COVER

Volume 19, Number 11



Opinion
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The introduction of transfer fees could revolutionise the scientific job market.

Brooke Morriswood and Oliver Hoeller
Published online 02.10.2018

Science & Society
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Natural products from plants and microorganisms are potent bioactive molecules that have been used in medicine, agriculture and cosmetics. Genomics and synthetic biology offer new tools to further explore their diversity for applications as fungicides or herbicides.

Yan Yan, Qikun Liu, Steven E Jacobsen and Yi Tang
Published online 25.10.2018

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Quality management systems have a long and proven track record in many businesses and clinical research. Such systems, when adapting to academic research, have great potential to improve rigor and reproducibility.

Ulrich Dirnagl, Claudia Kurreck, Esmeralda Castaños‐Vélez and René Bernard
Published online 19.10.2018

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How pluralistic ignorance can inhibit us from taking collective climate action and may affect similar problems such as public resistance to vaccination programs.

Esther Michelsen Kjeldahl and Vincent F Hendricks
Published online 22.10.2018

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Various psychoactive drugs have been shown to be effective for treating depression and other mental diseases. But clinical use and regulation requires a better understanding of how they work to optimize the risk‐benefit ratio.

Katrin Weigmann
Published online 15.10.2018

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Millennia of domestication have left their traces in the genomes of domesticated plants. Understanding these changes could inform breeding and genomic engineering approaches to improve yield and resilience of crops and other plants.

Philip Hunter
Published online 22.10.2018

Reviews
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Primary cilia are antenna‐like organelles that are essential for the regulation of several essential signaling pathways. This review highlights accumulating evidence that PC are not only involved in specific ciliopathies, but also play important roles in cancer.

Thibaut Eguether and Michael Hahne
Published online 22.10.2018

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Many bacteria directly manipulate their host cell in various phases of their infection cycle. This review describes how bacterial surface moieties, protein toxins and effector proteins interfere with essential host cell signalling pathways, thereby promoting cancer formation.

Daphne van Elsland and Jacques Neefjes
Published online 22.10.2018 Open Access

Scientific Reports
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Using single‐cell transcriptomics and multicolour flow cytometry this study presents comprehensive profiles of microglia in LPS‐injected mice, providing insight into microglia heterogeneity, and establishing a resource for the identification of specific phenotypes in CNS disorders.

Carole Sousa, Anna Golebiewska, Suresh K Poovathingal, Tony Kaoma, Yolanda Pires‐Afonso, Silvia Martina, Djalil Coowar, Francisco Azuaje, Alexander Skupin, Rudi Balling, Knut Biber, Simone P Niclou and Alessandro Michelucci
Published online 11.09.2018 Open Access

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During brain development, Ttyh1 maintains neural stem cell properties by enhancing Notch activity. This Ttyh1‐dependent increase of Notch signaling is achieved by destabilizing Rer1, thereby promoting γ‐secretase activity and NICD production.

Juwan Kim, Dasol Han, Sung‐Hyun Byun, Mookwang Kwon, Jae Youl Cho, Samuel J Pleasure and Keejung Yoon
Published online 03.09.2018

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SIRT2 targets the tumor suppressor p73, thereby deacetylating its C‐terminus and suppressing its transcriptional activity. SIRT2‐mediated inactivation of p73 is crucial for the tumorigenicity of glioblastoma cells.

Kosuke Funato, Tomoatsu Hayashi, Kanae Echizen, Lumi Negishi, Naomi Shimizu, Ryo Koyama‐Nasu, Yukiko Nasu‐Nishimura, Yasuyuki Morishita, Viviane Tabar, Tomoki Todo, Yasushi Ino, Akitake Mukasa, Nobuhito Saito and Tetsu Akiyama
Published online 13.09.2018

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Members of the ubiquitin‐like SUMO family can be posttranslationally attached to proteins as monomers or polymeric chains. The regulated acetylation of SUMO2/3 at lysine 11 favors the formation of non‐canonical SUMO chains.

Anne Gärtner, Kristina Wagner, Soraya Hölper, Kathrin Kunz, Manuel S Rodriguez and Stefan Müller
Published online 10.09.2018

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Spatially regulated competition between the de‐stabilizing Kinesin‐8 and the stabilizing Kinesin‐7 complex at the microtubule plus tip regulates the length of interphase microtubules in fission yeast.

John C Meadows, Liam J Messin, Anton Kamnev, Theresa C Lancaster, Mohan K Balasubramanian, Robert A Cross and Jonathan BA Millar
Published online 11.09.2018 Open Access

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Netrin‐1 activates PLCγ1 via Src kinase, which is crucial for axon guidance and corpus callosum and mDA system development.

Du‐Seock Kang, Yong Ryoul Yang, Cheol Lee, BumWoo Park, Kwang IL Park, Jeong Kon Seo, Young Kyo Seo, HyungJoon Cho, Cocco Lucio and Pann‐Ghill Suh
Published online 17.09.2018

Articles
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Distinct sub‐pools of ribbon‐associated and membrane‐proximal vesicles govern exocytosis at murine cochlear inner hair cells. Based on these findings, a vesicle route in the course of exocytosis is proposed for ribbon synapses.

Rituparna Chakrabarti, Susann Michanski and Carolin Wichmann
Published online 10.09.2018

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The activity of microtubule‐organizing centers during interphase is regulated in a hierarchical manner. The centrosome controls Golgi apparatus activity, and both of them inhibit γ‐tubulin‐dependent MT nucleation from cytoplasmic aggregates.

Maria P Gavilan, Pablo Gandolfo, Fernando R Balestra, Francisco Arias, Michel Bornens and Rosa M Rios
Published online 17.09.2018

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The conserved Mog1 protein is important for H2Bub1, H3K4me3, transcription, and mRNA export. This novel role is distinct from its known ability to bind Ran‐GTP during protein transport.

Paula Oliete‐Calvo, Joan Serrano‐Quílez, Carme Nuño‐Cabanes, María E Pérez‐Martínez, Luis M Soares, Bernhard Dichtl, Stephen Buratowski, José E Pérez‐Ortín and Susana Rodríguez‐Navarro
Published online 24.09.2018

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Mitochondrial mistranslation due to mutations in the mitochondrial 12S rRNA was proposed to cause hearing deficits. This study establishes a mouse model for mitochondrial mistranslation based on mutation of the mitoribosomal protein MRPS5, which recapitulates the suggested pathomechanism of the A1555G 12S rRNA mutation.

Rashid Akbergenov, Stefan Duscha, Ann‐Kristina Fritz, Reda Juskeviciene, Naoki Oishi, Karen Schmitt, Dimitri Shcherbakov, Youjin Teo, Heithem Boukari, Pietro Freihofer, Patricia Isnard‐Petit, Björn Oettinghaus, Stephan Frank, Kader Thiam, Hubert Rehrauer, Eric Westhof, Jochen Schacht, Anne Eckert, David Wolfer and Erik C Böttger
Published online 20.09.2018 Open Access

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By single‐cell RNA‐seq and ChIP‐seq analyses this study defines gene expression in spinal cord gliogenesis and reveals how sequentially expressed SOX proteins control glial gene expression in a temporal and sub‐lineage specific fashion.

Susanne Klum, Cécile Zaouter, Zhanna Alekseenko, Åsa K Björklund, Daniel W Hagey, Johan Ericson, Jonas Muhr and Maria Bergsland
Published online 30.08.2018

 
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