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maandag 15 oktober 2018

The Lancet: [News] Duvelisib in haematological malignancies

[News] Duvelisib in haematological malignancies
In patients with relapsed or refractory chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL), monotherapy with duvelisib shows encouraging anticancer activity with manageable toxicities, according to a recent study.
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[Articles] One-view breast tomosynthesis versus two-view mammography in the Malmö Breast Tomosynthesis Screening Trial (MBTST): a prospective, population-based, diagnostic accuracy study
Breast cancer screening by use of one-view digital breast tomosynthesis with a reduced compression force has higher sensitivity at a slightly lower specificity for breast cancer detection compared with two-view digital mammography and has the potential to reduce the radiation dose and screen-reading burden required by two-view digital breast tomosynthesis with two-view digital mammography.
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[Comment] Towards improving accuracy, effectiveness, and efficiency in breast cancer screening
Mammography screening contributes to reductions in mortality and morbidity from breast cancer through earlier detection of lesions. The sensitivity and specificity of digital mammography is reduced in some conditions, particularly in women with dense fibroglandular breasts within which overlying structures can mask cancers or mimic lesions that don't exist. Digital breast tomosynthesis is a refinement of digital mammography in which multiple low-dose x-ray projection images are acquired over a range of angles about the breast and used to reconstruct a quasi-3D image set.
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[Articles] Quality of life after postmastectomy radiotherapy in patients with intermediate-risk breast cancer (SUPREMO): 2-year follow-up results of a randomised controlled trial
Postmastectomy radiotherapy led to more local (chest wall) symptoms up to 2 years postrandomisation compared with no radiotherapy, but the difference between groups was small. These data will inform shared decision making while we await survival (trial primary endpoint) results.
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[Comment] The effect of postmastectomy radiotherapy on patient-reported outcomes
Postmastectomy radiotherapy is included in the management of breast cancer in an effort to eradicate potential microscopic residual disease within the chest wall or regional lymph nodes. In the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) 2014 meta-analysis, which included 8135 women in 22 trials, radiotherapy after mastectomy and axillary node dissection in women with one to three positive lymph nodes was associated with an 11·5% absolute reduction in the risk of any first recurrence and a 7·9% improvement in 20-year risk of breast cancer mortality.
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