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maandag 15 oktober 2018

The Lancet: [Articles] Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an o...

[Articles] Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial
The 7-day-dose metronidazole should be the preferred treatment for trichomoniasis among women.
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[Comment] The need for new treatment recommendations for trichomoniasis among women
Trichomoniasis is the most common non-viral sexually transmitted infection in the world. WHO estimates that 143 million new cases of trichomoniasis among young women occur each year.1 Trichomoniasis could cause serious adverse health effects, including increased risk for HIV acquisition, preterm birth, pelvic inflammatory disease, urethritis, vaginitis, and cervicitis.2 Currently, the US Centers for Disease Control and Prevention (CDC) and WHO recommend single-dose metronidazole (2 g single dose) or tinidazole as first-line treatment.
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[Review] Tuberculosis susceptibility and protection in children
Children represent both a clinically important population susceptible to tuberculosis and a key group in whom to study intrinsic and vaccine-induced mechanisms of protection. After exposure to Mycobacterium tuberculosis, children aged under 5 years are at high risk of progressing first to tuberculosis infection, then to tuberculosis disease and possibly disseminated forms of tuberculosis, with accompanying high risks of morbidity and mortality. Children aged 5–10 years are somewhat protected, until risk increases again in adolescence.
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[Review] Strategies to improve detection and management of human parechovirus infection in young infants
Human parechovirus infections are the second most common cause of viral meningitis in children. These infections are most frequently seen in infants younger than 90 days. Clinical manifestations include encephalitis, meningitis, myocarditis, and sepsis, which can lead to serious neurodevelopmental sequelae in young infants. Molecular techniques, including PCR assays, are the preferred diagnostic methods and have contributed to an increase in reported cases, along with an increasing awareness of the causal role of human parechovirus in infant diseases.
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[Review] Analysis of the clinical antibacterial and antituberculosis pipeline
This analysis of the global clinical antibacterial pipeline was done in support of the Global Action Plan on Antimicrobial Resistance. The study analysed to what extent antibacterial and antimycobacterial drugs for systemic human use as well as oral non-systemic antibacterial drugs for Clostridium difficile infections were active against pathogens included in the WHO priority pathogen list and their innovativeness measured by their absence of cross-resistance (new class, target, mode of action).
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