We bring you the latest news from the healthcare about the health care in the United Kingdom.

maandag 15 oktober 2018

The Lancet: [Articles] Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a p...

[Articles] Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
Among patients with ESUS who have PFO, anticoagulation might reduce the risk of recurrent stroke by about half, although substantial imprecision remains. Dedicated trials of anticoagulation versus antiplatelet therapy or PFO closure, or both, are warranted.
Read more

[Articles] Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially.
Read more

[Comment] The burden of Parkinson's disease: a worldwide perspective
Over history, diseases have appeared and disappeared, or have increased or decreased in frequency. These epidemiological trends have occurred more dramatically for infectious diseases (eg, the eradication of small pox), but have also occurred for chronic diseases (eg, reduction of vitamin deficiencies and cardiovascular disease).1 Over the past three or four decades, changing trends in the epidemiology of neurological diseases have been reported. In some high-income countries (primarily in North America and western Europe), the risk of stroke and dementia has declined, but the risk of Parkinson's disease and parkinsonism, amyotrophic lateral sclerosis, and late-onset multiple sclerosis has increased.
Read more

[In Context] Eve Marder: the world is her lobster
In the late 1960s, neuroscientists aiming to understand how the human brain worked were searching for a simpler network of neurons to study; one that reliably activated a stereotypical response, in which they would be able to identify the sensory nerve that detects the stimulus and the neural interchange that passes the message to a motor nerve. The stomatogastric ganglion (STG) of crustaceans fitted the bill particularly well as it is an independent network with a countable number of neurons (about thirty), a simple single input nerve, and an output to accessible stomach muscles.
Read more

[Articles] Safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy: a randomised, placebo-controlled trial
TMV remained stable in patients with spinal and bulbar muscular atrophy after being given BVS857 for 12 weeks. The intervention was associated with high incidence of immunogenicity and did not improve muscle strength or function. Additional studies might be needed to assess the efficacy of activating the IGF-1 pathway in this disease.
Read more