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woensdag 17 oktober 2018

The Lancet: [Articles] Outbreak of Neisseria meningitidis serogroup C outside the meningitis belt—Liberia, 2017: an...

[Articles] Outbreak of Neisseria meningitidis serogroup C outside the meningitis belt—Liberia, 2017: an epidemiological and laboratory investigation
This outbreak featured high attack and case fatality rates. Clinical presentation was broadly consistent with previous meningococcal disease outbreaks, but predominance of gastrointestinal symptoms was unusual compared with previous African meningitis epidemics. The outbreak strain was genetically similar to NmC CC10217, which caused meningococcal disease outbreaks in Niger and Nigeria. CC10217 had previously been identified only in the African meningitis belt.
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[Comment] Metagenomics for investigation of an unusual meningococcal outbreak
In The Lancet Infectious Diseases, Catherine H Bozio and colleagues1 described an unusual outbreak of meningococcal disease among attendees to a funeral in Liberia in April, 2017.
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[Series] Confronting the threat of bioterrorism: realities, challenges, and defensive strategies
Global terrorism is a rapidly growing threat to world security, and increases the risk of bioterrorism. In this Review, we discuss the potential threat of bioterrorism, agents that could be exploited, and recent developments in technologies and policy for detecting and controlling epidemics that have been initiated intentionally. The local and international response to infectious disease epidemics, such as the severe acute respiratory syndrome and west African Ebola virus epidemic, revealed serious shortcomings which bioterrorists might exploit when intentionally initiating an epidemic.
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[Media Watch] Reflecting on bioterrorism
Memories of plagues remain with us. The 1918 influenza pandemic, one of the greatest natural disasters in history, the devastating effects of Ebola virus disease in 2014, the toll of the HIV/AIDS pandemic, and resonances of the medieval Black Death are among the reminders that infectious diseases still evoke powerful images and fear. As I write, an Ebola virus disease outbreak in Democratic Republic of the Congo is just winding down, and Nipah virus has appeared again in India, causing 17 deaths.
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[Comment] Occult rifampicin-resistant tuberculosis: better assays are needed
Drug-resistant tuberculosis remains an important public health concern. A 2017 meta-analysis1 of published studies from India suggested that more than 40% of all Mycobacterium tuberculosis isolates included in the analysis were multidrug-resistant (MDR). Drug resistance is associated with high mortality despite treatment. Furthermore, prolonged therapy with multiple anti-tuberculosis drugs is onerous both for patients and the health system.
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