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vrijdag 5 oktober 2018

The Lancet: [Articles] Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pse...

[Articles] Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial
At very low concentrations, PP1131 decreased bacterial burden in burn wounds at a slower pace than standard of care. Further studies using increased phage concentrations and phagograms in a larger sample of participants are warranted.
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[Comment] Phage therapy 2.0: where do we stand?
In The Lancet Infectious Diseases, Patrick Jault and colleagues1 report the results of the PhagoBurn study investigating the efficacy and tolerability of a cocktail of bacteriophages against Pseudomonas aeruginosa in infected burn wounds.
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[Review] Antimicrobial resistance following mass azithromycin distribution for trachoma: a systematic review
Mass azithromycin distribution is a core component of trachoma control programmes and could reduce mortality in children younger than 5 years in some settings. In this systematic review we synthesise evidence on the emergence of antimicrobial resistance after mass azithromycin distribution. We searched electronic databases for publications up to June 14, 2018. We included studies of any type (excluding modelling studies, surveillance reports, and review articles) on community-wide distribution of oral azithromycin for the prevention and treatment of trachoma that assessed macrolide resistance, without restrictions to the type of organism.
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[Articles] Multiple introductions and subsequent transmission of multidrug-resistant Candida auris in the USA: a molecular epidemiological survey
Isolates of C auris in the USA were genetically related to those from four global regions, suggesting that C auris was introduced into the USA several times. The five travel-related cases are examples of how introductions can occur. Genetic diversity among isolates from the same patients, health-care facilities, and states indicates that there is local and ongoing transmission.
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[Comment] Candida auris: a global fungal public health threat
It was only 10 years ago that the US Centers for Disease Control and Prevention (CDC) predicted the emergence of new fungal pathogens as a growing public health problem.1 In parallel, while assessing global threats, the importance of mycology in public health has been predominantly ignored in several parts of the world.2 For example the European Centre for Disease Prevention and Control has no mycology experts in the team and WHO's global antimicrobial resistance surveillance system has only very recently considered emergence of resistance among fungal pathogens.
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