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Nature Reviews Immunology Contents November 2018 Volume 18 Number 11

Nature Reviews Immunology


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TABLE OF CONTENTS

November 2018 Volume 18, Issue 11

Comment
Research Highlights
Reviews
Perspectives
Amendments & Corrections

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Focal Point on Kobe

A seismic shift - How Kobe rebuilt itself after a devastating earthquake and turned into a biotechnology hub 


Comment

Are tolerance and training required to end TB?   
Maziar Divangahi
pp661 - 663 | doi:10.1038/s41577-018-0070-y
In this comment, Maziar Divangahi discusses the roles of disease tolerance and trained immunity in tuberculosis infection.
Full Text | PDF



Research Highlights

NETs awaken sleeping cancer cells
Yvonne Bordon
p665 | doi:10.1038/s41577-018-0081-8
Neutrophil extracellular traps awaken dormant cancer cells by remodelling the extracellular matrix.
PDF



There's NO limit
Yvonne Bordon
pp666 - 667 | doi:10.1038/s41577-018-0075-6
A quorum-sensing mechanism downregulates tissue inflammation by regulating metabolism in monocyte-derived cells.
PDF



lncRNA NKILA: a killer regulator
Lucy Bird
pp666 - 667 | doi:10.1038/s41577-018-0078-3
The long non-coding RNA NKILA sensitizes antitumour T cells to activation-induced cell death. Targeting this pathway can improve adoptive T cell therapy for cancer.
PDF



Making new memories
Laura K. Mackay
p667 | doi:10.1038/s41577-018-0064-9
Laura Mackay describes two landmark papers by Gebhardt et al. and Masopust et al., published in 2009 and 2010, that signified the advent of tissue-resident memory T cells as a distinct T cell subset.
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Autoreactive T cells in narcolepsy
Kirsty Minton
pp668 - 669 | doi:10.1038/s41577-018-0073-8
This study supports the suspected autoimmune nature of narcolepsy by showing that patients have memory T cells targeting self-antigens expressed by hypocretin neurons.
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Uncovering the mystery of secreted IgD
Alexandra Flemming
pp668 - 669 | doi:10.1038/s41577-018-0080-9
This study demonstrates that secreted IgD promotes protective humoral responses to soluble antigens such as food allergens.
PDF



Statins as adjuvants
Lucy Bird
p669 | doi:10.1038/s41577-018-0076-5
Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.
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Reviews

Natural killer cells and other innate lymphoid cells in cancer   
Laura Chiossone, Pierre-Yves Dumas, Margaux Vienne & Eric Vivier
pp671 - 688 | doi:10.1038/s41577-018-0061-z
Eric Vivier and colleagues discuss the emerging roles for natural killer (NK) cells and other innate lymphoid cell populations in cancer immunity. The authors highlight the current immunotherapy trials that are targeting NK cells to treat patients with cancer.
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Perivascular macrophages in health and disease   
Antonio Lapenna, Michele De Palma & Claire E. Lewis
pp689 - 702 | doi:10.1038/s41577-018-0056-9
This Review examines the functions of a specialized population of macrophages that make direct contact with or are found within one cell thickness of the abluminal surface of blood vessels in various tissues during both steady-state conditions and pathological processes.
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Forkhead box transcription factors as context-dependent regulators of lymphocyte homeostasis   
Dietmar M. W. Zaiss & Paul J. Coffer
pp703 - 715 | doi:10.1038/s41577-018-0048-9
This Review highlights the key roles of forkhead box transcription factors (FTFs) in regulating lymphocyte responses. The authors discuss how FTFs function as context-dependent rheostats, allowing lymphocytes to fine-tune their responses to diverse environmental challenges.
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Perspectives

Studying tissue macrophages in vitro: are iPSC-derived cells the answer?   
Christopher Z. W. Lee, Tatsuya Kozaki & Florent Ginhoux
pp716 - 725 | doi:10.1038/s41577-018-0054-y
Can macrophages derived from induced pluripotent stem cells (iPSCs) be used to effectively model in vivo tissue macrophages? Here, the authors consider the pros and cons of the different protocols for generating macrophages from iPSCs and suggest that a two-step model, based on ontogeny and tissue-specific microenvironment, enables the generation of biologically relevant macrophages.
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Amendments & Corrections

Author Correction: Natural killer cells and other innate lymphoid cells in cancer   
Laura Chiossone, Pierre-Yves Dumas, Margaux Vienne & Eric Vivier
p726 | doi:10.1038/s41577-018-0077-4
Full Text | PDF



Publisher Correction: Studying tissue macrophages in vitro: are iPSC-derived cells the answer?   
Christopher Z. W. Lee, Tatsuya Kozaki & Florent Ginhoux
p726 | doi:10.1038/s41577-018-0060-0
Full Text | PDF



Publisher Correction: T cells under starter's orders   
Kirsty Minton
p726 | doi:10.1038/s41577-018-0074-7
Full Text | PDF



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