We bring you the latest news from the healthcare about the health care in the United Kingdom.

donderdag 25 oktober 2018

Nature Reviews Cancer contents November 2018 Volume 18 Number 11

Nature Reviews Cancer


Advertisement
Do you have a career question? 

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.

Listen today!
TABLE OF CONTENTS

November 2018 Volume 18, Issue 11

Research Highlights
Reviews
Perspectives
Amendments & Corrections

Advertisement
===================================

Register for the latest nature.com webcast

Assembling High-quality Genomes to Solve Nature's Mysteries - Thursday, November 1, 2018 

Register for FREE today

Sponsored by Pac Bio

==================================
 

Research Highlights

BETting on YAP–TAZ
Ulrike Harjes
p663 | doi:10.1038/s41568-018-0065-9
Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
PDF



mRNA alterations mimic genetic mutations
Sarah Seton-Rogers
pp664 - 665 | doi:10.1038/s41568-018-0059-7
Lee, Singh et al. find that cancer-specific intronic polyadenylation events occur frequently in tumour suppressor genes in chronic lymphocytic leukaemia (CLL) and generate truncated proteins that could act as CLL drivers.
PDF



STAT3's true colours
Maria Giuseppina Baratta
pp664 - 665 | doi:10.1038/s41568-018-0062-z
D'Amico et al. show that, in the presence of oncogenic RAS mutations, STAT3 acts as a tumour modifier by regulating the epithelial differentiation of pancreatic and lung cancer cells via p63.
PDF



Neighbourly deaths dictate fate
Anna Dart
p665 | doi:10.1038/s41568-018-0064-x
Seehawer, Heinzmann et al. show that lineage commitment in liver cancer is independent of oncogenic driver expression and is instead dictated by the type of cell death occurring in the nearby liver microenvironment.
PDF



A multiplexed view of immune infiltration
Sarah Seton-Rogers
pp666 - 667 | doi:10.1038/s41568-018-0063-y
Keren et al. have used multiplexed imaging in intact samples from breast cancer patients to gain insights into the architecture of the tumour immune microenvironment.
PDF



Back to the beginning to understand metastasis
Sarah Seton-Rogers
pp666 - 667 | doi:10.1038/s41568-018-0069-5
Yang et al. have used genetically engineered mouse models of small cell lung cancer to show that the same genomic alterations in different cells of origin lead to the formation of tumours that follow distinct evolutionary paths to metastasis.
PDF



SPOP mutations disrupt phase separation
Sarah Seton-Rogers
p667 | doi:10.1038/s41568-018-0066-8
PDF



New targets for cancer immunotherapy
Anna Dart
p667 | doi:10.1038/s41568-018-0067-7
PDF



Oncogenic mRNA modification explained
Ulrike Harjes
p667 | doi:10.1038/s41568-018-0068-6
PDF



Nature Reviews Cancer
EVENT
17th International Congress on Hormonal Steroids and Hormones & Cancer
26.11.18
Stellenbosch, South Africa
More science events from

Reviews

Stem cell fate in cancer growth, progression and therapy resistance   
Nikki K. Lytle, Alison G. Barber & Tannishtha Reya
pp669 - 680 | doi:10.1038/s41568-018-0056-x
This Review discusses how cells with stem cell characteristics often serve as the tumour cell of origin, as they are preferentially primed for transformation. Furthermore, the activation of stem cell programmes can be crucial for promoting cancer progression and therapy resistance.
Full Text | PDF



Polyamine metabolism and cancer: treatments, challenges and opportunities   
Robert A. Casero Jr, Tracy Murray Stewart & Anthony E. Pegg
pp681 - 695 | doi:10.1038/s41568-018-0050-3
This Review discusses new insights into molecular mechanisms that link the dysregulation of polyamine metabolism with carcinogenesis and strategies for targeting this pathway for cancer therapy.
Full Text | PDF



The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers   
Zbyslaw Sondka, Sally Bamford, Charlotte G. Cole, Sari A. Ward, Ian Dunham et al.
pp696 - 705 | doi:10.1038/s41568-018-0060-1
This Review discusses the 2018 Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census (CGC), an expert-curated description of human cancer genes, which has recently been expanded to include functional descriptions of how each gene contributes to cancer.
Full Text | PDF



Advertisement
SPOTLIGHT ON KANAZAWA

An alternative Japan experience - Meet the sides of Japanese cities that most international researchers never see 
 

Perspectives

Fasting and cancer: molecular mechanisms and clinical application   
Alessio Nencioni, Irene Caffa, Salvatore Cortellino & Valter D. Longo
pp707 - 719 | doi:10.1038/s41568-018-0061-0
This Opinion discusses the potential of fasting and fasting-mimicking diets to help overcome toxicities induced by anticancer therapy. The differential response of normal and cancer cells undergoing starvation is argued to make normal cells less sensitive to therapy-induced toxicity, while cancer cells become more sensitive to therapy-induced cell death.
Full Text | PDF
Collection: Cancer at Nature Research


Advertisement
Nature Outlook: Brain cancer

The uncontrolled growth of a tumour inside the brain creates an extraordinarily potent threat to our being. A diagnosis of brain cancer still carries the high likelihood of death within five years. But efforts to prolong survival are advancing on several fronts.

Access free online

Produced with support from Novocure
 

Amendments & Corrections

Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities   
Michael J. Mitchell, Rakesh K. Jain & Robert Langer
p720 | doi:10.1038/s41568-018-0072-x
Full Text | PDF



Advertisement
Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours.

Click here to sign up.
 
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

This email has been sent to dezorgsector.uk@gmail.com.

If you no longer wish to receive the email alerts from Nature Reviews Cancer click here to unsubscribe .
If you wish to discontinue all email services from Nature Research please click here to unsubscribe .

For further technical assistance, please contact our registration department.

For print subscription enquiries, please contact our subscription department.

For other enquiries, please contact our customer feedback department.

Macmillan Publishers Limited is a company incorporated in England & Wales under company number 785998 & whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. Nature Research | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Nature is part of Springer Nature. © 2018 Springer Nature Limited. All rights reserved.

Springer Nature