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Nature Immunology Contents: November 2018 Volume 19  Issue 11

Nature Immunology


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TABLE OF CONTENTS

November 2018 Volume 19, Issue 11

Editorial
Research Highlights
News & Views
Meeting Reports
Perspectives
Review Articles
Articles

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A seismic shift - How Kobe rebuilt itself after a devastating earthquake and turned into a biotechnology hub
 

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Editorial

Old foes and new enemies    p1147
doi:10.1038/s41590-018-0252-6

Research Highlights

Antibodies and metabolites    p1148
Iona Visan
doi:10.1038/s41590-018-0244-6

Missile guidance for brain tumors    p1148
Laurie A. Dempsey
doi:10.1038/s41590-018-0245-5

CD153 combats Mtb infection    p1148
Laurie A. Dempsey
doi:10.1038/s41590-018-0246-4

Targeting cancer by Siglecs    p1148
Zoltan Fehervari
doi:10.1038/s41590-018-0247-3

B–T in MS    p1148
Zoltan Fehervari
doi:10.1038/s41590-018-0248-2

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News & Views

Targeting fibrin in neurodegeneration    pp1149 - 1150
Roland Martin
doi:10.1038/s41590-018-0241-9

Deposition of fibrin in the brain and central nervous system occurs after injury or disease. This process unmasks a conserved cryptic epitope of fibrin that activates microglia; blocking this interaction can limit inflammation and neurotoxicity.

Flat-lying antibody prevents disease enhancement    pp1150 - 1152
Shee-Mei Lok
doi:10.1038/s41590-018-0239-3

An antibody to dengue virus that lies flat on its target, neutralizes the virus and also prevents antibody-dependent enhancement of infection is now identified.

Remote control of γc expression by arginine methylation    pp1152 - 1154
Joo-Young Park & Jung-Hyun Park
doi:10.1038/s41590-018-0240-x

Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells by a post-transcriptional mechanism.

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Meeting Reports

Strategies for an HIV cure: progress and challenges    pp1155 - 1158
Fu Sheng Wang, Linqi Zhang, Daniel Douek, Andrew McMichael, Xiao-Ning Xu et al.
doi:10.1038/s41590-018-0242-8

The 'Strategies for an HIV Cure' conference was held 27–28 April 2018 in Beijing, China, and was hosted by The People's Republic of China Ministry of Science and Technology and the Chinese Academy of Sciences.

Perspectives

The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis    pp1159 - 1168
Akul Singhania, Robert J. Wilkinson, Marc Rodrigue, Pranabashis Haldar & Anne O'Garra
doi:10.1038/s41590-018-0225-9

O'Garra and colleagues describe the immune response to infection with Mycobacterium tuberculosis revealed through the use of transcriptomics and the value of blood transcriptional gene signatures for the diagnosis of tuberculosis.

Antibody-mediated protection against Ebola virus    pp1169 - 1178
Erica Ollmann Saphire, Sharon L. Schendel, Bronwyn M. Gunn, Jacob C. Milligan & Galit Alter
doi:10.1038/s41590-018-0233-9

Saphire and colleagues provide new insight into protective antibody-mediated responses to Ebola virus and how these responses could be harnessed for therapeutic intervention and vaccine strategies.

Review Articles

Recent progress in broadly neutralizing antibodies to HIV    pp1179 - 1188
Devin Sok & Dennis R. Burton
doi:10.1038/s41590-018-0235-7

Sok and Burton highlight recent developments in the discovery and application of antibodies able to neutralize diverse isolates of HIV, known as 'broadly neutralizing antibodies'.

The immune response against flaviviruses    pp1189 - 1198
Jose Luis Slon Campos, Juthathip Mongkolsapaya & Gavin R. Screaton
doi:10.1038/s41590-018-0210-3

Screaton and colleagues discuss the role of the adaptive immune response against flaviviruses in protection and pathogenesis, with emphasis on cross-reactive T cell and antibody responses.

Malaria prevention: from immunological concepts to effective vaccines and protective antibodies    pp1199 - 1211
Ian A. Cockburn & Robert A. Seder
doi:10.1038/s41590-018-0228-6

Malaria remains a disease of global importance, and a fully protective vaccine is elusive. In this Focus Review, Cockburn and Seder describe how insights into the biology of malaria biology may lead to the design of an effective vaccine.

Articles

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration    pp1212 - 1223
Jae Kyu Ryu, Victoria A. Rafalski, Anke Meyer-Franke, Ryan A. Adams, Suresh B. Poda et al.
doi:10.1038/s41590-018-0232-x

Fibrin deposition occurs after the blood–brain barrier is breached. Akassoglou and colleagues generate a therapeutic monoclonal antibody that targets a cryptic fibrin epitope to suppress activation of innate immune responses in the CNS and diminish neuroinflammation.

NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis    pp1224 - 1235
Zuliang Jie, Jin-Young Yang, Meidi Gu, Hui Wang, Xiaoping Xie et al.
doi:10.1038/s41590-018-0206-z

The kinase NIK activates a noncanonical NF-κB2 signaling pathway. Shao-Cong Sun and colleagues show that conditional loss of NIK in dendritic cells alters gut microbiome composition and TH17 cell responses, as a result of reduced expression of IL-23, pIgR and fecal IgA transcytosis.

Unique pattern of neutrophil migration and function during tumor progression    pp1236 - 1247
Sima Patel, Shuyu Fu, Jerome Mastio, George A. Dominguez, Abhilasha Purohit et al.
doi:10.1038/s41590-018-0229-5

Neutrophils are linked to tumor progression. Gabrilovich and colleagues demonstrate that neutrophils have tumor-stage-dependent alterations in motility, function and metabolism: in early phases, they are highly motile with altered metabolism, whereas at later stages, they become highly suppressive.

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus    pp1248 - 1256
Max Renner, Aleksandra Flanagan, Wanwisa Dejnirattisai, Chunya Puttikhunt, Watchara Kasinrerk et al.
doi:10.1038/s41590-018-0227-7

Immunity to one serotype of dengue virus can worsen disease following exposure to another serotype, a process called 'antibody-dependent enhancement'. Grimes and colleagues characterize the function and structural basis of an unusual, potent and broadly neutralizing antibody that lacks such activity.

Transcription-factor-mediated supervision of global genome architecture maintains B cell identity    pp1257 - 1264
Timothy M. Johanson, Aaron T. L. Lun, Hannah D. Coughlan, Tania Tan, Gordon K. Smyth et al.
doi:10.1038/s41590-018-0234-8

The transcription factor Pax5 enforces B cell identity. Nutt, Allan and colleagues show that Pax5 is needed to establish and maintain the three-dimensional genome organization of B cells throughout their lineage development.

Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance    pp1265 - 1276
Maia Inoue, Kazuo Okamoto, Asuka Terashima, Takeshi Nitta, Ryunosuke Muro et al.
doi:10.1038/s41590-018-0222-z

PRMT arginine methyltransferases mediate post-translational modification. Takayanagi and colleagues show that a lack of PRMT5 in cells of the T cell lineage compromises their response to cytokines dependent on the common γ-chain, due to aberrant splicing of mRNA transcripts encoding the common γ-chain and its associated kinase JAK3.

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