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donderdag 18 oktober 2018

Nature contents: 18 October 2018

  journal cover  
Nature Volume 562 Issue 7727
This Week  
Progress on antibiotic resistance
Revealed: the extraordinary flight of the dandelion
Journal blacklists: show your working
World View  
The biggest pandemic risk? Viral misinformation
Heidi J. Larson
Research Highlights  
This issue's Research Highlights
Selections from the scientific literature.
Seven Days  
Rocket crash, alcohol warnings and astronomy's leaky pipeline
News in Focus
Supercharged crime-scene DNA analysis sparks privacy concerns
Ewen Callaway
Argentina's scientists struggle amid slipping peso and rising inflation
Michele Catanzaro
Tsunami scientists clash with Indonesian government over rules on foreign research
Quirin Schiermeier
French plant biologist cleared of misconduct in new inquiry
Declan Butler
Climate change is about to make your beer more expensive
Matthew Warren
All systems go for second-ever mission to enter Mercury's orbit
Davide Castelvecchi
The internet of animals that could help to save vanishing wildlife
Andrew Curry
What legal weed in Canada means for science
Elie Dolgin
Nature Podcast 18 October 2018
This week, how science can help Canadian cannabis growers and a potted history of the Sun.
The uncontrolled growth of a tumour inside the brain creates an extraordinarily potent threat to our being. A diagnosis of brain cancer still carries the high likelihood of death within five years. But efforts to prolong survival are advancing on several fronts.
Produced with support from 
Retool AI to forecast and limit wars
Weisi Guo, Kristian Gleditsch, Alan Wilson
Books and Arts  
Rotten meat and bottled formaldehyde: fighting for food safety
Felicity Lawrence
Genes unleashed: how the Victorians engineered our dogs
Meg Daley Olmert
The evolution of music, algorithmic culture, and the cut and thrust of medicine: New in paperback
Mary Craig
The global tide of blood in history, medicine and culture
Tilli Tansey
Black-hole chronicles: chasing the gravitational beast
Richard Panek
Promises and pitfalls of imaging the brain
Chris Baker
Atomic bombs through wars hot and cold
Sarah Robey
Act now to close chemical-weapons loophole
Lijun Shang, Michael Crowley, Malcolm Dando
Co-produced data: open access tests trust
Jacqueline L. Stroud
Encourage early-career scientists to shape policy
Norma Bethke, Paul Gellert, Joachim Seybold
All scientists deserve a break from e-mail on holiday — not just professors
Jan Philipp Röer
No need for juvenile language in Nature
Stephen E. Moss
Real-life stories of online harassment — and how scientists got through it
Virginia Gewin
Cancer researcher defends immigrant scientists
Virginia Gewin
Career Briefs  
Why China is a hotspot for international students
Why fewer women than men ask questions at conferences

D. A. Xiaolin Spires
Genome organization and DNA accessibility control antigenic variation in trypanosomes
Long-read sequencing allows the assembly of antigen-gene arrays in Trypanosoma brucei and, coupled with deletion experiments, demonstrates that histone variants act as a molecular link between genome architecture, chromatin conformation and antigen variation.
Laura S. M. Müller, Raúl O. Cosentino, Konrad U. Förstner et al.
Chromatin clues to the trypanosome parasite's uniform coat
The parasite Trypanosoma brucei causes sleeping sickness. It evades human defences by changing the version of a protein that coats its surface. Analysis of its genome and nuclear structure clarifies this variation process.
Steve Kelly, Mark Carrington
Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex at 3.6 Å resolution
Near-atomic resolution cryo-electron microscopy structures of the Zaire ebolavirus nucleoprotein indicate a complex transition from the RNA-free to RNA-bound forms of the protein, and reveal the mechanism of oligomer formation and helical assembly.
Yukihiko Sugita, Hideyuki Matsunami, Yoshihiro Kawaoka et al.
A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour
A dopaminergic mesocortical circuit in juvenile zebra finches detects the presence of an adult zebra finch tutor and helps to encode the performance of the tutor, facilitating the cultural transmission of vocal behaviour.
Masashi Tanaka, Fangmiao Sun, Yulong Li et al.
Functional genomic landscape of acute myeloid leukaemia
Analyses of samples from patients with acute myeloid leukaemia reveal that drug response is associated with mutational status and gene expression; the generated dataset provides a basis for future clinical and functional studies of this disease.
Jeffrey W. Tyner, Cristina E. Tognon, Daniel Bottomly et al.
Biodiversity increases and decreases ecosystem stability
Species richness was found to increase temporal stability but decrease resistance to warming in an experiment involving 690 micro-ecosystems consisting of 1 to 6 species of bacterivorous ciliates that were sampled over 40 days.
Frank Pennekamp, Mikael Pontarp, Andrea Tabi et al.
A cortico-cerebellar loop for motor planning
The cerebellum is critical for the coding of future movement in the frontal cortex.
Zhenyu Gao, Courtney Davis, Alyse M. Thomas et al.
Proposed early signs of life not set in stone
Efforts to find early traces of life on Earth often focus on structures in ancient rocks, called stromatolites, that formed by microbial activity. One of the oldest proposed stromatolite discoveries has now been questioned.
Mark A. van Zuilen
Reassessing evidence of life in 3,700-million-year-old rocks of Greenland
In contrast to a previous study of 3,700-million-year-old rocks of the Isua supracrustal belt in Greenland, which presented fossil evidence of stromatolites (macroscopic remains of layered microbial communities), this study shows that these 'stromatolites' are features of deformation unconnected to the processes of organic life.
Abigail C. Allwood, Minik T. Rosing, David T. Flannery et al.
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
The receptor LILRB4 on monocytic leukaemia cells suppresses T cell activity and supports the infiltration of tumour cells into tissues.
Mi Deng, Xun Gui, Jaehyup Kim et al.
A two per cent Hubble constant measurement from standard sirens within five years
Gravitational-wave observations of binary neutron-star mergers will enable precision measurements of the Hubble constant within five years.
Hsin-Yu Chen, Maya Fishbach, Daniel E. Holz
From the archive
What Nature was saying 50 and 100 years ago.
Security and eavesdropping in terahertz wireless links
Contrary to current expectation, eavesdropping on terahertz wireless data links is shown to be easier than expected, by placing an object in the path of the signal that scatters part of it to a receiver located elsewhere.
Jianjun Ma, Rabi Shrestha, Jacob Adelberg et al.
Transcription factor dimerization activates the p300 acetyltransferase
The activation of the histone acetyltransferase p300 depends on the activation and oligomerization status of transcription factor ligands.
Esther Ortega, Srinivasan Rengachari, Ziad Ibrahim et al.
A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling
Inhibition of the glycolytic enzyme PGK1 using a small molecular probe reveals a molecular link between glycolysis and the KEAP1–NRF2 signalling cascade.
Michael J. Bollong, Gihoon Lee, John S. Coukos et al.
A protein functionalization platform based on selective reactions at methionine residues
This methionine-selective functionalization strategy uses hypervalent iodine reagents to introduce new groups via the formation of a sulfonium intermediate, which can then undergo further visible-light-mediated reactions to form a diverse range of protein conjugates.
Michael T. Taylor, Jennifer E. Nelson, Marcos G. Suero et al.
News & Views  
Cermet material could aid the development of future power plants
Craig Turchi
CRISPR tool puts RNA on the record
Chase L. Beisel
Twenty-five years of using microlensing to study dark matter
Grzegorz Pietrzyński
Register for the latest nature.com webcast
Characterisation of 3D Printed Materials in the Electron Microscope
Wednesday, October 17
3D printing enables the fast production of high quality, bespoke components. When this technique is applied in the production of metals and alloys it opens new possibilities in many areas as diverse, as biomedicine, automotive and aerospace manufacturing.
A living display system resolved pixel by pixel
Adrien Jouary, Christian K. Machens
Exploring the Universe with matter waves
Liang Liu
The eukaryotic ancestor shapes up
Laura Eme, Thijs J. G. Ettema
Brief Communications Arising  
Re-evaluating the p7 viroporin structure
Benjamin P. Oestringer, Juan H. Bolivar, Mario Hensen et al.
Chen et al. reply
Wen Chen, Bo OuYang, James J. Chou
Improved limit on the electric dipole moment of the electron
An experimental measurement of the electric dipole moment of the electron with sensitivity an order of magnitude better than previous studies increases the accessible mass range of fundamental particles by a factor of three.
ACME Collaboration
Elucidating the control and development of skin patterning in cuttlefish
Tracking analyses of tens of thousands of individual chromatophores in freely behaving cephalopods enable studies of behaviour and development at cellular resolution.
Sam Reiter, Philipp Hülsdunk, Theodosia Woo et al.
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
A 'mouse atlas', comprising single-cell transcriptomic data from more than 100,000 cells from 20 organs and tissues, has been created as a resource for cell biology.
The Tabula Muris Consortium
The genetic basis and cell of origin of mixed phenotype acute leukaemia
A large-scale genomics study shows that the cell of origin and founding mutations determine disease subtype and lead to the expression of multiple haematopoietic lineage-defining antigens in mixed phenotype acute leukaemia.
Thomas B. Alexander, Zhaohui Gu, Ilaria Iacobucci et al.
Transcriptional recording by CRISPR spacer acquisition from RNA
An RNA-adapting CRISPR–Cas system is coupled with amplification and sequencing steps to record, retrieve and analyse changes in the transcriptome of a bacterial cell over time.
Florian Schmidt, Mariia Y. Cherepkova, Randall J. Platt
The dispersion–brightness relation for fast radio bursts from a wide-field survey
A large-scale survey of fast radio bursts—short pulses of radio waves that seem to come from cosmological distances—finds 20 such events, including both the nearest and the most energetic bursts observed so far.
R. M. Shannon, J.-P. Macquart, K. W. Bannister et al.
Space-borne Bose–Einstein condensation for precision interferometry
A Bose–Einstein condensate is created in space that has sufficient stability to enable its characteristic dynamics to be studied.
Dennis Becker, Maike D. Lachmann, Stephan T. Seidel et al.
Subcycle observation of lightwave-driven Dirac currents in a topological surface band
Time- and angle-resolved photoemission spectroscopy reveals how Dirac fermions in the band structure of the topological surface state of Bi2Te3 are accelerated by the carrier wave of a terahertz-frequency light pulse.
J. Reimann, S. Schlauderer, C. P. Schmid et al.
Battery-operated integrated frequency comb generator
Integrating an optical Kerr frequency comb source with an electronically excited laser pump produces a battery-powered comb generator that does not require external lasers, moveable optics or laboratory set-ups.
Brian Stern, Xingchen Ji, Yoshitomo Okawachi et al.
Ceramic–metal composites for heat exchangers in concentrated solar power plants
A robust ceramic/refractory metal (ZrC/W)-based composite for use in heat exchangers in concentrated solar power plants above 1,023 kelvin is described, having attractive high-temperature thermal, mechanical and chemical properties combined with cost-effective processing.
M. Caccia, M. Tabandeh-Khorshid, G. Itskos et al.
Glacial expansion of oxygen-depleted seawater in the eastern tropical Pacific
A downward expansion of oxygen depletion in the eastern Pacific Ocean during the last ice age suggests an increase in the respired carbon reservoir, contributing to the lower levels of atmospheric carbon dioxide during this period.
Babette A. A. Hoogakker, Zunli Lu, Natalie Umling et al.
A separated vortex ring underlies the flight of the dandelion
The flight of dandelion seeds is enabled by an extraordinary vortex ring, which was revealed by the visualization of the flow around the seed.
Cathal Cummins, Madeleine Seale, Alice Macente et al.
Cervical excitatory neurons sustain breathing after spinal cord injury
A population of cervical interneurons is identified that can regulate diaphragm function by modulating phrenic motor neurons; targeting this small population of neurons may be a functional strategy to restore breathing after traumatic spinal cord injury.
Kajana Satkunendrarajah, Spyridon K. Karadimas, Alex M. Laliberte et al.
IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
In human and mouse models of ovarian cancer, endoplasmic reticulum stress and the activation of the IRE1α–XBP1 pathway decreases the metabolic fitness of T cells and limits their anti-tumour functions.
Minkyung Song, Tito A. Sandoval, Chang-Suk Chae et al.
A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition
When basal cell carcinoma is treated with a Smoothened inhibitor, a subset of cancer cells evades treatment by switching identity, allowing residual tumours to regrow when treatment is discontinued.
Brian Biehs, Gerrit J. P. Dijkgraaf, Robert Piskol et al.
A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy
Treatment of basal cell carcinoma with Smoothened inhibitors leaves a small population of quiescent cells that can drive relapse but can be eliminated by additional treatment with a Wnt signalling inhibitor.
Adriana Sánchez-Danés, Jean-Christophe Larsimont, Mélanie Liagre et al.
Genomes of Asgard archaea encode profilins that regulate actin
Asgard archaea encode functional profilins that can interact with mammalian actin, which suggests that—similar to eukaryotic cells—they possess a regulated actin cytoskeleton.
Caner Akıl, Robert C. Robinson
Handover mechanism of the growing pilus by the bacterial outer-membrane usher FimD
The structure of a pilus assembly intermediate reveals the timing of subunit polymerization and how chaperone–subunit complexes are transferred from N-terminal to C-terminal domains of the usher in the formation of bacterial pili.
Minge Du, Zuanning Yuan, Hongjun Yu et al.
Amendments & Corrections
Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche
Ysbrand M. Nusse, Adam K. Savage, Pauline Marangoni et al.
Publisher Correction: Challenging local realism with human choices
The BIG Bell Test Collaboration
Addendum: Preventing the return of fear in humans using reconsolidation update mechanisms
Daniela Schiller, Marie-H. Monfils, Candace M. Raio et al.
Nature Outlook  
Science without borders
Spotlight on Western Australia

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Frontiers in Cancer Science (FCS) 2018


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