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Nature Communications - 03 October 2018

 
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Bacterial dynamin-like proteins reveal mechanism for membrane fusion OPEN
Marc Bramkamp
28 September 2018 | doi: 10.1038/s41467-018-06559-6
Bacteria  Structural biology 

Cancer cells with trapped nuclei cut their way through the extracellular matrix OPEN
Emmanuel Dornier & Jim C. Norman
27 September 2018 | doi: 10.1038/s41467-018-06351-6
Breast cancer  Cancer  Cancer microenvironment  Cell adhesion  Cell biology 
 
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An ultra-low thiourea catalyzed strain-release glycosylation and a multicatalytic diversification strategy OPEN
Chunfa Xu & Charles C. J. Loh

Non-covalent glycosyl donor activation often requires high organocatalyst loadings. Here, the authors demonstrate that strain-release glycosylations can take place at very low thiourea catalyst loadings. In addition, the authors developed a one-pot multicatalytic strategy that can diversify glycosides rapidly.

03 October 2018 | doi: 10.1038/s41467-018-06329-4
Carbohydrate chemistry  Diversity-oriented synthesis  Synthetic chemistry methodology  Organocatalysis 

Combined impacts of deforestation and wildlife trade on tropical biodiversity are severely underestimated OPEN
William S. Symes, David P. Edwards, Jukka Miettinen, Frank E. Rheindt & L. Roman Carrasco

Disentangling multiple drivers of species declines can be difficult yet is critical to species conservation. Here, the authors parse the relative contributions of deforestation and trapping to declines of native birds in Southeast Asia, finding that the extinction risk of trapped species may be underestimated.

03 October 2018 | doi: 10.1038/s41467-018-06579-2
Biodiversity  Conservation biology  Tropical ecology 

Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family OPEN
Valentina Klymiuk, Elitsur Yaniv, Lin Huang, Dina Raats, Andrii Fatiukha, Shisheng Chen, Lihua Feng, Zeev Frenkel, Tamar Krugman, Gabriel Lidzbarsky, Wei Chang, Marko J. Jääskeläinen, Christian Schudoma, Lars Paulin, Pia Laine, Harbans Bariana, Hanan Sela, Kamran Saleem, Chris Khadgi Sørensen, Mogens S. Hovmøller et al.

Yellow rust fungus severely limits global wheat production and breeding of durable resistance is challenging. Here Klymiuk et al. isolate the broad-spectrum Yr15 resistance gene from wild emmer wheat and show that it is a member of a distinct tandem kinase-pseudokinase family of plant proteins.

03 October 2018 | doi: 10.1038/s41467-018-06138-9
Biotic  Evolutionary biology  Plant breeding 

Bi-directional cell-pericellular matrix interactions direct stem cell fate OPEN
Silvia A. Ferreira, Meghna S. Motwani, Peter A. Faull, Alexis J. Seymour, Tracy T. L. Yu, Marjan Enayati, Dheraj K. Taheem, Christoph Salzlechner, Tabasom Haghighi, Ewa M. Kania, Oommen P. Oommen, Tarek Ahmed, Sandra Loaiza, Katarzyna Parzych, Francesco Dazzi, Oommen P. Varghese, Frederic Festy, Agamemnon E. Grigoriadis, Holger W. Auner, Ambrosius P. Snijders et al.

3D hydrogels have provided information on the physical requirements of stem cell fate, but the contribution of interactions with the pericellular environment are under-explored. Here the authors show that pericellular matrix secreted by human bone marrow stromal cells (hMSC) embedded in a HA-based hydrogel contribute to hMSC fate.

03 October 2018 | doi: 10.1038/s41467-018-06183-4
Biomaterials – cells  Stem-cell differentiation 

Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis OPEN
Chiharu Kimura-Yoshida, Kyoko Mochida, Masa-aki Nakaya, Takeomi Mizutani & Isao Matsuo

The transcription factor Grhl3 is known to play a role in the nucleus during epidermal differentiation. Here, the authors report that Grhl3 is also cytoplasmic and membrane-localized, increasing mechanical stiffness by upregulating actomyosin networks.

03 October 2018 | doi: 10.1038/s41467-018-06171-8
Cell signalling  Morphogenesis 

Turning a native or corroded Mg alloy surface into an anti-corrosion coating in excited CO2 OPEN
Yuecun Wang, Boyu Liu, Xin'ai Zhao, Xionghu Zhang, Yucong Miao, Nan Yang, Bo Yang, Liqiang Zhang, Wenjun Kuang, Ju Li, Evan Ma & Zhiwei Shan

Magnesium alloys usually have poor corrosion resistance, which inhibits their use in the automotive and biomedical industries. Here, the authors use an environmental TEM to carbonate the natural corrosion products at the surface of magnesium alloys and form a compact and protective surface layer.

03 October 2018 | doi: 10.1038/s41467-018-06433-5
Corrosion  Metals and alloys  Surfaces, interfaces and thin films 

High-content ductile coherent nanoprecipitates achieve ultrastrong high-entropy alloys OPEN
Yao-Jian Liang, Linjing Wang, Yuren Wen, Baoyuan Cheng, Qinli Wu, Tangqing Cao, Qian Xiao, Yunfei Xue, Gang Sha, Yandong Wang, Yang Ren, Xiaoyan Li, Lu Wang, Fuchi Wang & Hongnian Cai

High entropy alloys usually emphasize equiatomic compositions, which restrict the compositions available to induce strengthening via precipitation. Here the authors use spinodal decomposition in a five-element alloy to obtain high content nanophases and the highest tensile strength reported to date.

03 October 2018 | doi: 10.1038/s41467-018-06600-8
Mechanical properties  Metals and alloys 

Reconfigurable MEMS Fano metasurfaces with multiple-input–output states for logic operations at terahertz frequencies OPEN
Manukumara Manjappa, Prakash Pitchappa, Navab Singh, Nan Wang, Nikolay I. Zheludev, Chengkuo Lee & Ranjan Singh

Here, the authors demonstrate excitation and active tuning of sharp Fano resonances in a MEMS reconfigurable metasurface possessing multiple-input-output states. They realize XOR, XNOR, NOT and NAND logic gate operations by using two independently controllable electrical inputs and an optical readout using terahertz beam.

03 October 2018 | doi: 10.1038/s41467-018-06360-5
Metamaterials  Photonic devices  Terahertz optics 

Coherently driven microcavity-polaritons and the question of superfluidity OPEN
R. T. Juggins, J. Keeling & M. H. Szymańska

Driven-dissipative microcavity polariton experiments find superfluid-like behaviour but the intuition developed from equilibrium systems cannot be straightforwardly applied. Juggins et al. show coherently-driven polaritons are not superfluid and earlier observations instead arise from a distinct rigid state.

03 October 2018 | doi: 10.1038/s41467-018-06436-2
Polaritons  Quantum fluids and solids 

Enhanced voltage generation through electrolyte flow on liquid-filled surfaces OPEN
B. Fan, A. Bhattacharya & P. R. Bandaru

Superhydrophobic surfaces are expected to increase streaming potential, but are hindered by the presence of air. Here the authors enhance streaming potential by flowing high-dielectric salt water over liquid-filled surfaces infiltrated with low-dielectric liquid, harnessing electric slip and surface charge.

03 October 2018 | doi: 10.1038/s41467-018-06297-9
Devices for energy harvesting  Electrochemistry  Surface patterning 

Polymerization driven monomer passage through monolayer chemical vapour deposition graphene OPEN
Tao Zhang, Zhongquan Liao, Leonardo Medrano Sandonas, Arezoo Dianat, Xiaoling Liu, Peng Xiao, Ihsan Amin, Rafael Gutierrez, Tao Chen, Ehrenfried Zschech, Gianaurelio Cuniberti & Rainer Jordan

Translocation of larger molecules through graphene holds potential for molecular sieving, however it is rarely observed. Here, the authors show the radical polymerization of vinyl monomers via their translocation through a single layer graphene to a monolayer initiator and additionally study the monomer-graphene interactions.

03 October 2018 | doi: 10.1038/s41467-018-06599-y
Polymer characterization  Polymers  Self-assembly  Two-dimensional materials 

 OPEN
Wolfgang Hornfeck, Raphael Kobold, Matthias Kolbe, Matthias Conrad & Dieter Herlach

Elucidating the formation of quasicrystals, which have long-range orientational order but no translation periodicity, remains a challenge. Here, the authors track and geometrically describe how a decagonal nickel–zirconium seed grows into a tenfold twinned dendritic structure.

03 October 2018 | doi: 10.1038/s41467-018-06597-0
Metals and alloys  Structure of solids and liquids  Synthesis and processing 

Ancient proteins from ceramic vessels at Çatalhöyük West reveal the hidden cuisine of early farmers OPEN
Jessica Hendy, Andre C. Colonese, Ingmar Franz, Ricardo Fernandes, Roman Fischer, David Orton, Alexandre Lucquin, Luke Spindler, Jana Anvari, Elizabeth Stroud, Peter F. Biehl, Camilla Speller, Nicole Boivin, Meaghan Mackie, Rosa R. Jersie-Christensen, Jesper V. Olsen, Matthew J. Collins, Oliver E. Craig & Eva Rosenstock

Ancient diets have been reconstructed from archaeological pottery based on lipid remains, but these can lack specificity. Here, Hendy and colleagues analyze ancient proteins from ceramic vessels up to 8000 years old to produce a more nuanced understanding of ancient food processing and diet.

03 October 2018 | doi: 10.1038/s41467-018-06335-6
Anthropology  Archaeology  Lipids  Proteins 

Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder OPEN
Marisa W. Friederich, Sharita Timal, Christopher A. Powell, Cristina Dallabona, Alina Kurolap, Sara Palacios-Zambrano, Drago Bratkovic, Terry G. J. Derks, David Bick, Katelijne Bouman, Kathryn C. Chatfield, Nadine Damouny-Naoum, Megan K. Dishop, Tzipora C. Falik-Zaccai, Fuad Fares, Ayalla Fedida, Ileana Ferrero, Renata C. Gallagher, Rafael Garesse, Micol Gilberti et al.

Mitochondrial protein synthesis requires charging a mitochondrial tRNA with its amino acid. Here, the authors describe pathogenic variants in the GatCAB protein complex genes required for the generation of glutaminyl-mt-tRNAGln, that impairs mitochondrial translation and presents with cardiomyopathy.

03 October 2018 | doi: 10.1038/s41467-018-06250-w
Cardiomyopathies  Genetics research  Medical genetics  Multienzyme complexes 

Reprogramming of regulatory network using expression uncovers sex-specific gene regulation in Drosophila OPEN
Yijie Wang, Dong-Yeon Cho, Hangnoh Lee, Justin Fear, Brian Oliver & Teresa M. Przytycka

For many applications knowledge of context-specific gene regulatory networks (GRNs) is desirable, but their inference remains a challenge. Here, the authors introduce a method for construction of context-specific GRNs, and apply it to construct sex-specific Drosophila GRNs.

03 October 2018 | doi: 10.1038/s41467-018-06382-z
Gene regulatory networks  Network topology 

Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2 OPEN
Matías A. Goldin, Evan R. Harrell, Luc Estebanez & Daniel E. Shulz

Sensory tuning properties of neurons in the secondary whisker somatosensory cortex (wS2) are not well understood. Here, the authors report that wS2 neurons supralinearly integrate concurrent multi-whisker input with larger temporal windows than primary somatosensory cortex.

03 October 2018 | doi: 10.1038/s41467-018-06585-4
Barrel cortex  Cortex  Sensory processing  Whisker system 

A hierarchical anti-Hebbian network model for the formation of spatial cells in three-dimensional space OPEN
Karthik Soman, Srinivasa Chakravarthy & Michael M. Yartsev

Neurons in the hippocampal formation encode diverse spatial properties. Here, the authors present a hierarchical network model for 3D spatial navigation that accounts for the observed neuronal representations and predict as yet unreported cell types with planar selectivity.

02 October 2018 | doi: 10.1038/s41467-018-06441-5
Computational neuroscience  Neuroscience 

Molecular architecture and regulation of BCL10-MALT1 filaments OPEN
Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss, Karl-Peter Hopfner, Irina Gutsche, Daniel Krappmann & Katja Lammens

The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.

02 October 2018 | doi: 10.1038/s41467-018-06573-8
Cryoelectron microscopy  NF-kappaB 

Observing of the super-Planckian near-field thermal radiation between graphene sheets OPEN
Jiang Yang, Wei Du, Yishu Su, Yang Fu, Shaoxiang Gong, Sailing He & Yungui Ma

Though monolayer graphene has the potential to be used in near-field thermal management applications, no experimental verification has been provided to date. Here, the authors directly measure plasmon-enhanced near-field heat transfer between graphene sheets on intrinsic silicon substrates.

02 October 2018 | doi: 10.1038/s41467-018-06163-8
Nanophotonics and plasmonics  Optical properties and devices 

Zebra finches identify individuals using vocal signatures unique to each call type OPEN
Julie E. Elie & Frédéric E. Theunissen

Individual animals have vocal signatures, but are the same signatures consistent across behavioral contexts? Here, the authors use behavioral experiments and acoustic analyses to show that zebra finches have distinct vocal signatures for different call types, such as aggression and long-distance contact.

02 October 2018 | doi: 10.1038/s41467-018-06394-9
Animal behaviour  Signal processing 

Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects OPEN

Sharing of whole genome sequencing (WGS) data improves study scale and power, but data from different groups are often incompatible. Here, US genome centers and NIH programs define WGS data processing standards and a flexible validation method, facilitating collaboration in human genetics research.

02 October 2018 | doi: 10.1038/s41467-018-06159-4
Data processing  Genome informatics  Sequencing 

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies OPEN
Andreas H. Laustsen, Aneesh Karatt-Vellatt, Edward W. Masters, Ana Silvia Arias, Urska Pus, Cecilie Knudsen, Saioa Oscoz, Peter Slavny, Daniel T. Griffiths, Alice M. Luther, Rachael A. Leah, Majken Lindholm, Bruno Lomonte, José María Gutiérrez & John McCafferty

Current anti-venoms against black mamba (Dendroaspis polylepis) bites are animal-derived and associated with several limitations. Here, Laustsen and colleagues develop an experimental recombinant anti-venom based on oligoclonal human IgG antibodies and establish its potential protective value in neutralizing dendrotoxin-mediated neurotoxicity using venom challenge in vivo models.

02 October 2018 | doi: 10.1038/s41467-018-06086-4
Antibody therapy  Applied immunology  Translational research 

Computational design of chemogenetic and optogenetic split proteins OPEN
Onur Dagliyan, Andrey Krokhotin, Irem Ozkan-Dagliyan, Alexander Deiters, Channing J. Der, Klaus M. Hahn & Nikolay V. Dokholyan

Designing split protein approaches is time consuming and often results in high background activity due to spontaneous assembly. Here the authors present an automated approach which uses a split energy scoring function to identify optimal protein split sites and reduces spontaneous assembly.

02 October 2018 | doi: 10.1038/s41467-018-06531-4
Chemical genetics  Computational biophysics  Optogenetics  Protein design  Synthetic biology 

RIP2 filament formation is required for NOD2 dependent NF-κB signalling OPEN
Erika Pellegrini, Ambroise Desfosses, Arndt Wallmann, Wiebke Manuela Schulze, Kristina Rehbein, Philippe Mas, Luca Signor, Stephanie Gaudon, Grasilda Zenkeviciute, Michael Hons, Helene Malet, Irina Gutsche, Carsten Sachse, Guy Schoehn, Hartmut Oschkinat & Stephen Cusack

Binding of bacterial peptidoglycan muramyl dipeptides induces NOD2 activation and signalling via the downstream adaptor kinase RIP2. Here the authors show that RIP2 forms filaments via its CARD domain, analyse the structure of the CARD filaments and demonstrate the requirement of RIP2 polymerisation for the activation of NF-κB by NOD2.

02 October 2018 | doi: 10.1038/s41467-018-06451-3
Cryoelectron microscopy  NOD-like receptors  Solid-state NMR  X-ray crystallography 

LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes OPEN
Li Zhu, Suresh K. Kandasamy, Susan E. Liao & Ryuya Fukunaga

The RNA-binding protein MARF1 is required for post-transcriptional regulation of mRNAs during mouse oogenesis. Here, by analyzing a Drosophila MARF1 mutant, the authors show that MARF1 recruits CCR4-NOT deadenylase to shorten the poly-A tails of target mRNAs such as cyclin A and suppress their translation during Drosophila oogenesis.

02 October 2018 | doi: 10.1038/s41467-018-06404-w
Biochemistry  Developmental biology  Genetics  RNA-binding proteins 

Two-dimensional amorphous NiO as a plasmonic photocatalyst for solar H2 evolution OPEN
Zhaoyong Lin, Chun Du, Bo Yan, Chengxin Wang & Guowei Yang

While photocatalysis offers a means to store solar energy as chemical fuels, photocatalysts typically require crystalline structures and expensive noble-metal cocatalysts. Here, authors prepare 2D amorphous nano-nickel oxide capable of plasmonic, photodriven H2 evolution without cocatalysts.

02 October 2018 | doi: 10.1038/s41467-018-06456-y
Devices for energy harvesting  Heterogeneous catalysis  Photocatalysis  Two-dimensional materials 

Tailoring manganese oxide with atomic precision to increase surface site availability for oxygen reduction catalysis OPEN
C. John Eom, Ding-Yuan Kuo, Carolina Adamo, Eun Ju Moon, Steve J. May, Ethan J. Crumlin, Darrell G. Schlom & Jin Suntivich

Controlling structures at the atomic level provides an opportunity to design and understand catalysts. Here the authors use thin-film deposition to fabricate perovskite heterostructures in a non-equilibrium manner to assess the effects on electrocatalytic activity for oxygen reduction.

02 October 2018 | doi: 10.1038/s41467-018-06503-8
Design, synthesis and processing  Materials for energy and catalysis 

Tensorial neutron tomography of three-dimensional magnetic vector fields in bulk materials OPEN
A. Hilger, I. Manke, N. Kardjilov, M. Osenberg, H. Markötter & J. Banhart

Mapping the distribution of magnetic fields inside bulk materials is challenging but crucial to understand and develop functional magnetic materials. Here the authors demonstrate the capability to visualize 3D vector magnetic fields inside materials using spin-polarized neutron tomography and tensorial reconstruction techniques.

02 October 2018 | doi: 10.1038/s41467-018-06593-4
Experimental nuclear physics  Imaging techniques  Magnetic properties and materials 

Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes OPEN
Zhe Wei, Jessica Greaney, Chenxi Zhou & Hayden A. Homer

Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase. The authors find that Cdk1 inactivation triggers F-actin dependent post-anaphase spindle migration, resulting in cortical protrusion.

02 October 2018 | doi: 10.1038/s41467-018-06510-9
Actin  Cytokinesis  Kinases  Meiosis 

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator OPEN
Sunhee Hwang, Karen Mruk, Simin Rahighi, Andrew G. Raub, Che-Hong Chen, Lisa E. Dorn, Naoki Horikoshi, Soichi Wakatsuki, James K. Chen & Daria Mochly-Rosen

Glucose-6-phosphate dehydrogenase (G6PD) deficiency provides insufficient protection from oxidative stress, contributing to diverse human pathologies. Here, the authors identify a small molecule that increases the activity and/or stability of mutant G6PD and show that it reduces oxidative stress in zebrafish and hemolysis in isolated human erythrocytes.

02 October 2018 | doi: 10.1038/s41467-018-06447-z
Drug discovery  Molecular medicine 

Vibrational control of selective bond cleavage in dissociative chemisorption of methanol on Cu(111) OPEN
Jialu Chen, Xueyao Zhou, Yaolong Zhang & Bin Jiang

Dissociative chemisorption of methanol on metal surfaces is a key step for hydrogen production. Here the authors use quasi-quantized molecular dynamics simulations to alter the branching ratios for methanol dissociative chemisorption on Cu(111) via selectively exciting specific vibrational modes.

02 October 2018 | doi: 10.1038/s41467-018-06478-6
Catalysis  Computational chemistry  Reaction kinetics and dynamics 

Dye-incorporated coordination polymers for direct photocatalytic trifluoromethylation of aromatics at metabolically susceptible positions OPEN
Tiexin Zhang, Xiangyang Guo, Yusheng Shi, Cheng He & Chunying Duan

Direct trifluoromethylation of unactivated aromatic rings at metabolically susceptible positions is highly desirable in pharmaceutical fields. Here, the authors report a new approach for direct trifluoromethylation of unactivated aromatics by incorporating thiophenes into the backbone of triphenylamine-based ligand.

02 October 2018 | doi: 10.1038/s41467-018-05919-6
Catalyst synthesis  Synthetic chemistry methodology  Photocatalysis 

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation OPEN
Chao Sheng, Johannes Jungverdorben, Hendrik Wiethoff, Qiong Lin, Lea J. Flitsch, Daniela Eckert, Matthias Hebisch, Julia Fischer, Jaideep Kesavan, Beatrice Weykopf, Linda Schneider, Dominik Holtkamp, Heinz Beck, Andreas Till, Ullrich Wüllner, Michael J. Ziller, Wolfgang Wagner, Michael Peitz & Oliver Brüstle

Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures.

02 October 2018 | doi: 10.1038/s41467-018-06398-5
Ageing  Epigenetic memory  Neural stem cells  Reprogramming  Transdifferentiation 

Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors OPEN
Marta Roccio, Michael Perny, Megan Ealy, Hans Ruedi Widmer, Stefan Heller & Pascal Senn

Hearing requires mechanosensitive hair cells in the organ of Corti, which derive from progenitors of the cochlear duct. Here the authors examine human inner ear development by studying key developmental markers and describe organoid cultures from human cochlear duct progenitors for in vitro hair cell differentiation.

02 October 2018 | doi: 10.1038/s41467-018-06334-7
Cochlea  Stem cells 

Exacerbated fires in Mediterranean Europe due to anthropogenic warming projected with non-stationary climate-fire models OPEN
Marco Turco, Juan José Rosa-Cánovas, Joaquín Bedia, Sonia Jerez, Juan Pedro Montávez, Maria Carmen Llasat & Antonello Provenzale

A warmer and drier climate will affect wildfire activity but the climate-fire relationship could change under warming. Here the authors use models with a non-stationary climate-fire relationship to show that to avoid doubling the burned area in the coming decades we must stay below 1.5 °C Paris target.

02 October 2018 | doi: 10.1038/s41467-018-06358-z
Climate-change impacts  Natural hazards  Projection and prediction 

Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane OPEN
Alexander Benjamin Schendzielorz, Piotr Bragoszewski, Nataliia Naumenko, Ridhima Gomkale, Christian Schulz, Bernard Guiard, Agnieszka Chacinska & Peter Rehling

The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane. Here authors show that the import motor J-protein Pam18 controls lateral protein release into the lipid bilayer.

02 October 2018 | doi: 10.1038/s41467-018-06492-8
Biochemistry  Mitochondrial proteins  Proteins 

Dereplication of microbial metabolites through database search of mass spectra OPEN
Hosein Mohimani, Alexey Gurevich, Alexander Shlemov, Alla Mikheenko, Anton Korobeynikov, Liu Cao, Egor Shcherbin, Louis-Felix Nothias, Pieter C. Dorrestein & Pavel A. Pevzner

New natural products can be identified via mass spectrometry by excluding all known ones from the analysis, a process called dereplication. Here, the authors extend a previously published dereplication algorithm to different classes of secondary metabolites.

02 October 2018 | doi: 10.1038/s41467-018-06082-8
Data mining  Natural products 

Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape OPEN
Paul Adrian Ginno, Lukas Burger, Jan Seebacher, Vytautas Iesmantavicius & Dirk Schübeler

Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory landscape.

02 October 2018 | doi: 10.1038/s41467-018-06007-5
Chromatin analysis  Epigenetics  Mitosis  Proteomics 

Locally-curved geometry generates bending cracks in the African elephant skin OPEN
António F. Martins, Nigel C. Bennett, Sylvie Clavel, Herman Groenewald, Sean Hensman, Stefan Hoby, Antoine Joris, Paul R. Manger & Michel C. Milinkovitch

The skin of the African bush elephant features micrometer-wide channels whose function is water and mud retention for thermal regulation and protection from parasites. Here authors use microscopy and modelling to show that the channels are fractures of the animal thick and brittle skin outermost layer.

02 October 2018 | doi: 10.1038/s41467-018-06257-3
Biological physics  Zoology 

Total syntheses of shizukaols A and E OPEN
Jian-Li Wu, Yin-Suo Lu, Bencan Tang & Xiao-Shui Peng

Shizukaols, bioactive dimers naturally occurring in the Chloranthaceae family, possess a complex polycyclic framework with more than ten contiguous stereocenters. Here the authors report the total syntheses of shizukaols A and E achieved via a modified Diels–Alder reaction mimicking the biosynthetic pathway.

02 October 2018 | doi: 10.1038/s41467-018-06245-7
Synthetic chemistry methodology  Natural product synthesis 

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors OPEN
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes & Richard J. A. Wilson

Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-specific receptors and that systemic TRPV1 and LPA-specific receptor antagonists ameliorate acute bronchoconstriction.

02 October 2018 | doi: 10.1038/s41467-018-06189-y
Asthma  Transient receptor potential channels 

Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction OPEN
Benjamin Steinhorn, Andrea Sorrentino, Sachin Badole, Yulia Bogdanova, Vsevolod Belousov & Thomas Michel

Excessive production of reactive oxygen species (ROS) is associated with cardiac dysfunction, but the causal role of ROS remains poorly understood. Here the authors use an in vivo chemogenetic approach to develop a heart failure model in which generation of hydrogen peroxide in the heart leads to systolic heart failure without fibrotic remodeling.

02 October 2018 | doi: 10.1038/s41467-018-06533-2
Animal disease models  Heart failure  Stress signalling 

Advanced sulfide solid electrolyte by core-shell structural design OPEN
Fan Wu, William Fitzhugh, Luhan Ye, Jiaxin Ning & Xin Li

Sulfide electrolyte materials offer the opportunity for the development of solid-state batteries. Here the authors further improve the voltage stability of core-shell structured sulfides by modifying the microstructures, and pair the optimized electrolytes with lithium metal anode into battery devices.

02 October 2018 | doi: 10.1038/s41467-018-06123-2
Energy science and technology  Materials science 

Megahertz serial crystallography OPEN
Max O. Wiedorn, Dominik Oberthür, Richard Bean, Robin Schubert, Nadine Werner, Brian Abbey, Martin Aepfelbacher, Luigi Adriano, Aschkan Allahgholi, Nasser Al-Qudami, Jakob Andreasson, Steve Aplin, Salah Awel, Kartik Ayyer, Saša Bajt, Imrich Barák, Sadia Bari, Johan Bielecki, Sabine Botha, Djelloul Boukhelef et al.

The new European X-Ray Free-Electron Laser (EuXFEL) is the first XFEL that generates X-ray pulses with a megahertz inter-pulse spacing. Here the authors demonstrate that high-quality and damage-free protein structures can be obtained with the currently available 1.1 MHz repetition rate pulses using lysozyme as a test case and furthermore present a β-lactamase structure.

02 October 2018 | doi: 10.1038/s41467-018-06156-7
Imaging techniques  Nanocrystallography 

Multibandgap quantum dot ensembles for solar-matched infrared energy harvesting OPEN
Bin Sun, Olivier Ouellette, F. Pelayo García de Arquer, Oleksandr Voznyy, Younghoon Kim, Mingyang Wei, Andrew H. Proppe, Makhsud I. Saidaminov, Jixian Xu, Mengxia Liu, Peicheng Li, James Z. Fan, Jea Woong Jo, Hairen Tan, Furui Tan, Sjoerd Hoogland, Zheng Hong Lu, Shana O. Kelley & Edward H. Sargent

Efficient harvest of solar energy beyond the silicon absorption edge of 1100 nm by semiconductor solar cells remains a challenge. Here Sun et al. mix high multi-bandgap lead sulfide colloidal quantum dot ensembles to further increase both short circuit current and open circuit voltage.

01 October 2018 | doi: 10.1038/s41467-018-06342-7
Quantum dots  Solar cells 

Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells OPEN
Maria Montserrat Garcia Romero, Gareth McCathie, Philip Jankun & Henry Hamilton Roehl

Reactive oxygen species (ROS) are required to initiate regeneration but the mechanisms regulating its production are unclear. Here, the authors show in zebrafish larval tail regeneration that ROS is released by mobilised notochord cells enables their repositioning in the damage site, assisted by secreted Hh.

01 October 2018 | doi: 10.1038/s41467-018-06460-2
Regeneration  Stem cells 

Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies OPEN
Vincent Madelain, Sylvain Baize, Frédéric Jacquot, Stéphanie Reynard, Alexandra Fizet, Stephane Barron, Caroline Solas, Bruno Lacarelle, Caroline Carbonnelle, France Mentré, Hervé Raoul, Xavier de Lamballerie & Jérémie Guedj

Optimization of antiviral therapy can be crucial in the management of Ebola virus outbreaks. Here, Madelain et al. use an integrative mathematical model to correlate the dose and the time of treatment initiation with survival rate, enhanced immune response and viral clearance.

01 October 2018 | doi: 10.1038/s41467-018-06215-z
Computational biology and bioinformatics  Diseases  Microbiology 

Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma OPEN
Jessica Tome-Garcia, Parsa Erfani, German Nudelman, Alexander M. Tsankov, Igor Katsyv, Rut Tejero, Bin Zhang, Martin Walsh, Roland H. Friedel, Elena Zaslavsky & Nadejda M. Tsankova

The intrinsic drivers of glioblastoma (GBM) migration are still poorly understood. Here the authors purify GBM stem cells (GSCs) from patients and profile chromatin accessibility in these cells, identifying TEAD1 as a regulator of migration in human glioblastoma.

01 October 2018 | doi: 10.1038/s41467-018-06258-2
Cancer stem cells  Cell migration  Chromatin structure  Transcriptional regulatory elements 

Digital coding of mechanical stress in a dynamic covalent shape memory polymer network OPEN
Guogao Zhang, Wenjun Peng, Jingjun Wu, Qian Zhao & Tao Xie

Stresses are often detrimental to the mechanical properties of materials but when well controlled can lead to unusual opportunities in various technological areas. Here the authors report a digital photothermal mechanism enabled laser printing that allows freedom in stress manipulation in dynamic covalent shape memory polymers.

01 October 2018 | doi: 10.1038/s41467-018-06420-w
Polymer chemistry  Polymers 

Pastoralism may have delayed the end of the green Sahara OPEN
Chris Brierley, Katie Manning & Mark Maslin

Climate deterioration towards desertification in North Africa following the African Humid Period has previously been associated with the emergence of pastoralism. Here, using a climate-vegetation model, the authors show that pastoralism in fact likely slowed the deterioration of orbitally-driven climate change.

01 October 2018 | doi: 10.1038/s41467-018-06321-y
Climate-change adaptation  Palaeoclimate  Sustainability 

Carrier density and disorder tuned superconductor-metal transition in a two-dimensional electron system OPEN
Zhuoyu Chen, Adrian G. Swartz, Hyeok Yoon, Hisashi Inoue, Tyler A. Merz, Di Lu, Yanwu Xie, Hongtao Yuan, Yasuyuki Hikita, Srinivas Raghu & Harold Y. Hwang

Studying quantum phase transitions at oxide interfaces provide a key to understand emergent two-dimensional (2D) superconductivity. Here, Chen et al. report comprehensive electronic phase diagram of the 2D electron system at the superconducting LaAlO3/SrTiO3 interface with independent control of carrier density and disorder.

01 October 2018 | doi: 10.1038/s41467-018-06444-2
Superconducting devices  Superconducting properties and materials  Surfaces, interfaces and thin films 

Coupled microbial bloom and oxygenation decline recorded by magnetofossils during the Palaeocene–Eocene Thermal Maximum OPEN
Liao Chang, Richard J. Harrison, Fan Zeng, Thomas A. Berndt, Andrew P. Roberts, David Heslop & Xiang Zhao

Understanding the response of marine productivity and CO2 drawdown to past warming events can provide important insights into the future. Here, the authors use bacterial magnetite nanoparticle fossils to reconstruct nutrient supply and marine deoxygenation during the Palaeocene–Eocene Thermal Maximum.

01 October 2018 | doi: 10.1038/s41467-018-06472-y
Palaeoceanography  Palaeomagnetism 

Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity OPEN
Lulu Yao, Teddy Grand, Jesse Hanson, Pierre Paoletti & Qiang Zhou

Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a finding with important implications for selective pharmacological targeting of inhibitory neuron NMDA receptors.

01 October 2018 | doi: 10.1038/s41467-018-06512-7
Neuroscience  Physiology 

Femtosecond photoexcitation dynamics inside a quantum solvent OPEN
Bernhard Thaler, Sascha Ranftl, Pascal Heim, Stefan Cesnik, Leonhard Treiber, Ralf Meyer, Andreas W. Hauser, Wolfgang E. Ernst & Markus Koch

Femtosecond laser spectroscopy has contributed to our understanding of structure and function of matter. Here, the authors explore the applicability of superfluid helium nanodroplets as a sample preparation method that allows investigation of previously inaccessible classes of tailor-made or fragile molecular systems.

01 October 2018 | doi: 10.1038/s41467-018-06413-9
Atomic and molecular interactions with photons  Photochemistry 

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection OPEN
Pooja Munnilal Tiwari, Daryll Vanover, Kevin E. Lindsay, Swapnil Subhash Bawage, Jonathan L. Kirschman, Sushma Bhosle, Aaron W. Lifland, Chiara Zurla & Philip J. Santangelo

Engineered neutralizing antibodies are potential therapeutics for numerous viruses, such as respiratory syncytial virus (RSV). Here, the authors develop an mRNA-based approach to express membrane-anchored neutralizing antibodies in the lung and demonstrate that it inhibits RSV infections in mice.

01 October 2018 | doi: 10.1038/s41467-018-06508-3
Antibodies  RNA vaccines  Viral infection 

Efficient photocatalytic hydrogen evolution with ligand engineered all-inorganic InP and InP/ZnS colloidal quantum dots OPEN
Shan Yu, Xiang-Bing Fan, Xian Wang, Jingguo Li, Qian Zhang, Andong Xia, Shiqian Wei, Li-Zhu Wu, Ying Zhou & Greta R. Patzke

While quantum dots show high efficiency solar-to-fuel conversion for renewable energy, the frequently toxic elements employed present severe safety concerns. Here, authors demonstrate indium phosphide quantum dots as low-toxicity alternatives alongside efficient hydrogen evolution photocatalysis.

01 October 2018 | doi: 10.1038/s41467-018-06294-y
Nanoparticles  Photocatalysis  Solar fuels 

A flow platform for degradation-free CuAAC bioconjugation OPEN
Marine Z. C. Hatit, Linus F. Reichenbach, John M. Tobin, Filipe Vilela, Glenn A. Burley & Allan J. B. Watson

Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a common bioconjugation technique; however oxidative degradation and residual copper may limit its use. Here, the authors show that ppm levels of Cu, generated in situ by solvent-mediated pipe erosion in flow, catalyze the CuAAC reaction with no product degradation.

01 October 2018 | doi: 10.1038/s41467-018-06551-0
Chemical biology  Homogeneous catalysis  Sustainability 

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline OPEN
Marco L. Hennrich, Natalie Romanov, Patrick Horn, Samira Jaeger, Volker Eckstein, Violetta Steeples, Fei Ye, Ximing Ding, Laura Poisa-Beiro, Mang Ching Lai, Benjamin Lang, Jacqueline Boultwood, Thomas Luft, Judith B. Zaugg, Andrea Pellagatti, Peer Bork, Patrick Aloy, Anne-Claude Gavin & Anthony D. Ho

Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid differentiation.

01 October 2018 | doi: 10.1038/s41467-018-06353-4
Ageing  Haematopoietic stem cells  Mesenchymal stem cells 

Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism OPEN
Kumar Nagarathinam, Yoshiko Nakada-Nakura, Christoph Parthier, Tohru Terada, Narinobu Juge, Frank Jaenecke, Kehong Liu, Yunhon Hotta, Takaaki Miyaji, Hiroshi Omote, So Iwata, Norimichi Nomura, Milton T. Stubbs & Mikio Tanabe

The multidrug resistance transporter mediated efflux of antibiotics from the bacterial cytoplasm represents a major challenge to medicine. Here authors solve the X-ray crystallographic structure of the drug/H+ antiporter MdfA from Escherichia coli and shed light on the conformational switching mechanism.

01 October 2018 | doi: 10.1038/s41467-018-06306-x
Membrane proteins  X-ray crystallography 

Regulatory control of DNA end resection by Sae2 phosphorylation OPEN
Elda Cannavo, Dominic Johnson, Sara N. Andres, Vera M. Kissling, Julia K. Reinert, Valerie Garcia, Dorothy A. Erie, Daniel Hess, Nicolas H. Thomä, Radoslav I. Enchev, Matthias Peter, R. Scott Williams, Matt J. Neale & Petr Cejka

It has previously been established that DNA end resection in yeast and in humans is under CDK control. Here the authors explain how phosphorylation regulates the capacity of Sae2 — the yeast orthologue of human CtIP — to promote DNA end resection.

01 October 2018 | doi: 10.1038/s41467-018-06417-5
Double-strand DNA breaks  Enzyme mechanisms  Phosphoproteins 

Strong coupling and induced transparency at room temperature with single quantum dots and gap plasmons OPEN
Haixu Leng, Brian Szychowski, Marie-Christine Daniel & Matthew Pelton

The signatures of strong and intermediate plasmon-emitter coupling can be confused if scattering measurements alone are performed. Here, the authors use scattering and photoluminescence to demonstrate weak, intermediate, and strong coupling between single quantum dots and plasmons at room temperature.

01 October 2018 | doi: 10.1038/s41467-018-06450-4
Nanoparticles  Nanophotonics and plasmonics  Optical physics  Quantum dots 

LISA improves statistical analysis for fMRI OPEN
Gabriele Lohmann, Johannes Stelzer, Eric Lacosse, Vinod J. Kumar, Karsten Mueller, Esther Kuehn, Wolfgang Grodd & Klaus Scheffler

Functional magnetic resonance imaging (fMRI) is a powerful technique for measuring human brain activity, but the statistical analysis of fMRI data can be difficult. Here, the authors introduce a new fMRI analysis tool, LISA, which provides increased statistical power compared to existing techniques.

01 October 2018 | doi: 10.1038/s41467-018-06304-z
Computational neuroscience  Data processing  Neural circuits  Statistics 

Silencing of TGFβ signalling in microglia results in impaired homeostasis OPEN
Tanja Zöller, Artur Schneider, Christian Kleimeyer, Takahiro Masuda, Phani Sankar Potru, Dietmar Pfeifer, Thomas Blank, Marco Prinz & Björn Spittau

While previous studies had shown the requirement of TGFβ signalling in microglia gene expression, the specificity of the loss-of-function was unclear. Here, Zöller and colleagues generate microglia specific cKO of TGFβ receptor 2, and show dispensable function of Tgfbr2 in microglial survival and the requirement of Tgfbr2 in morphological and transcriptional homeostasis of adult microglia.

01 October 2018 | doi: 10.1038/s41467-018-06224-y
Glial biology  Microglia  Neuroimmunology  Neuroscience 

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition OPEN
Julien Robert-Paganin, Daniel Auguin & Anne Houdusse

Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to group mutations in classes and to elucidate the molecular mechanisms leading to cardiac dysfunction in HCM.

01 October 2018 | doi: 10.1038/s41467-018-06191-4
Cardiac hypertrophy  Myosin  X-ray crystallography 

Interface dominated cooperative nanoprecipitation in interstitial alloys OPEN
Hongcai Wang, Xie Zhang, Dingshun Yan, Christoph Somsen & Gunther Eggeler

The specifics of nanoscale precipitation in steels remain complex. Here the authors combine high-resolution microscopy and atomistic simulations to identify a cooperative growth mechanism leading to the preferential growth of cementite nanoprecipitates along a specific crystallographic direction.

01 October 2018 | doi: 10.1038/s41467-018-06474-w
Atomistic models  Metals and alloys  Nanoscale materials 

Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma OPEN
Sarah E. Arthur, Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, Laura K. Hilton, Prince Kumar Lat, Eric Y. Zhao, Luka Culibrk, Daisuke Ennishi, Selin Jessa, Lauren Chong, Nicole Thomas, Prasath Pararajalingam, Barbara Meissner, Merrill Boyle, Jordan Davidson, Kevin R. Bushell et al.

The driver mutations for the two main molecular subgroups of diffuse large B-cell lymphoma (DLBCL) are poorly defined. Here, an integrative genomics analysis identifies 3′ UTR NFKBIZ mutations within the activated B-cell DLBCL subgroup and small FCGR2B amplifications in the germinal centre B-cell DLBCL subgroup.

01 October 2018 | doi: 10.1038/s41467-018-06354-3
Cancer genomics  Immunological disorders 

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation OPEN
Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros & Walter Marcotti

Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell identity in adult mice.

01 October 2018 | doi: 10.1038/s41467-018-06307-w
Hair cell  Sensory processing  Transduction 

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma OPEN
Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann et al.

Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib while heterozygous methylation of BRCA1 predicts resistance in HGSOC.

28 September 2018 | doi: 10.1038/s41467-018-05564-z
DNA methylation  Homologous recombination  Ovarian cancer  Targeted therapies 

Structural basis of neurosteroid anesthetic action on GABAA receptors OPEN
Qiang Chen, Marta M. Wells, Palaniappa Arjunan, Tommy S. Tillman, Aina E. Cohen, Yan Xu & Pei Tang

The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the development of new GABAAR modulators.

28 September 2018 | doi: 10.1038/s41467-018-06361-4
Biophysics  Neuroscience  Structural biology 

Clonal dynamics in osteosarcoma defined by RGB marking OPEN
Stefano Gambera, Ander Abarrategi, Fernando González-Camacho, Álvaro Morales-Molina, Josep Roma, Arantzazu Alfranca & Javier García-Castro

Osteosarcoma is a heterogeneous bone tumour with a high mutational rate. Here the authors use an RGB-based single-cell tracking system to track clonal dynamics in a mouse model of osteosarcoma, which their findings indicate follows a neutral evolution model in which different clones simultaneously coexist and propagate.

28 September 2018 | doi: 10.1038/s41467-018-06401-z
Bone cancer  Bone development  Cancer microenvironment  Cancer models  Paediatric research 

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy OPEN
Yi-Chang Wang, Yu-Syuan Wu, Chia-Yang Hung, Shao-An Wang, Ming-Jer Young, Tsung-I Hsu & Jan-Jong Hung

USP24 has previously been reported to be involved in cancer progression. Here, the authors demonstrate that USP24 stabilizes p300 and β-TrCP to increase the levels of NF-κB and histone-3 acetylation, and decrease DNMT1 and IκB levels which promotes IL-6 expression in M2 macrophages and lung cancer cells.

28 September 2018 | doi: 10.1038/s41467-018-06178-1
Cancer  Cancer microenvironment  Cell biology  Molecular biology 

Atomically precise graphene etch stops for three dimensional integrated systems from two dimensional material heterostructures OPEN
Jangyup Son, Junyoung Kwon, SunPhil Kim, Yinchuan Lv, Jaehyung Yu, Jong-Young Lee, Huije Ryu, Kenji Watanabe, Takashi Taniguchi, Rita Garrido-Menacho, Nadya Mason, Elif Ertekin, Pinshane Y. Huang, Gwan-Hyoung Lee & Arend M. van der Zande

Fabrication methods to pattern thin materials are a critical tool to build molecular scale devices. Here the authors report a selective etching method using XeF2 gas to pattern graphene based heterostructures with multiple active layers and achieve 1D contacts with low contact resistivity of 80 Ω·µm

28 September 2018 | doi: 10.1038/s41467-018-06524-3
Electronic properties and devices  Molecular electronics  NEMS  Two-dimensional materials 

Cooperative supramolecular polymers with anthracene‒endoperoxide photo-switching for fluorescent anti-counterfeiting OPEN
Zhao Gao, Yifei Han & Feng Wang

There is a continual pursuit for different ways to detect counterfeiting in today's society. Here the authors show photo-responsive supramolecular polymers can be used in fluorescent anti-counterfeit applications, by taking advantage of multicycle anthracene‒endoperoxide switching properties.

28 September 2018 | doi: 10.1038/s41467-018-06392-x
Light harvesting  Self-assembly  Supramolecular polymers 

Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus OPEN
Allison Sang, Thomas Danhorn, Jacob N. Peterson, Andrew L. Rankin, Brian P. O'Connor, Sonia M. Leach, Raul M. Torres & Roberta Pelanda

Conventional B cells express clonally specific antigen receptors, but a small subset of B cells from patients and mice with systematic lupus erythematosus simultaneously expresses two distinct antigen receptors. Here the authors show that these dual-specificity B cells have higher levels of MHC-II, depend on IL-21 for expansion, and mount stronger memory response.

28 September 2018 | doi: 10.1038/s41467-018-06293-z
Autoimmunity  B cells  Systemic lupus erythematosus  Translational immunology 

A modified serine cycle in Escherichia coli coverts methanol and CO2 to two-carbon compounds OPEN
Hong Yu & James C. Liao

Assimilating the abundant one-carbon compounds by an industrially-relevant microorganism can broaden the substrate range and achieve reactions that are difficult for chemical process. Here the authors show a modified serine cycle can convert methanol and CO2 to two-carbon compounds in an engineered E. coli strain.

28 September 2018 | doi: 10.1038/s41467-018-06496-4
Applied microbiology  Metabolic engineering  Metabolic pathways 

A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation OPEN
Mathieu Letellier, Zsófia Szíber, Ingrid Chamma, Camille Saphy, Ioanna Papasideri, Béatrice Tessier, Matthieu Sainlos, Katalin Czöndör & Olivier Thoumine

Neuroligins are postsynaptic cell adhesion molecules thought to play roles in synaptic development and function. Here, authors show that phosphorylation of Y782 in neuroligin-1 modulates its role in differentiation and ability to recruit AMPARs including during long-term potentiation.

28 September 2018 | doi: 10.1038/s41467-018-06220-2
Cellular neuroscience  Synaptic development 

Predicting wave overtopping thresholds on coral reef-island shorelines with future sea-level rise OPEN
E. Beetham & P. S. Kench

Sea-level rise will exacerbate wave overtopping on low-lying coral reef islands. Here the authors present a novel method that quantifies wave overtopping thresholds and associated reef-island vulnerability trajectories based on differences in local wave climate, reef morphology and island height.

28 September 2018 | doi: 10.1038/s41467-018-06550-1
Climate-change impacts  Natural hazards  Physical oceanography 

Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography OPEN
Yinglong Wu, Shuailing Huang, Jun Wang, Lihe Sun, Fang Zeng & Shuizhu Wu

Optoacoustic tomography has great potential for medical diagnosis and preclinical research. Here they develop near infrared activatable xanthene-based optoacoustic probes for diagnosing and localizing drug-induced liver injury and metastasis in mouse models.

28 September 2018 | doi: 10.1038/s41467-018-06499-1
Optical imaging  Photoacoustics 

Curvotaxis directs cell migration through cell-scale curvature landscapes OPEN
Laurent Pieuchot, Julie Marteau, Alain Guignandon, Thomas Dos Santos, Isabelle Brigaud, Pierre-François Chauvy, Thomas Cloatre, Arnaud Ponche, Tatiana Petithory, Pablo Rougerie, Maxime Vassaux, Jean-Louis Milan, Nayana Tusamda Wakhloo, Arnaud Spangenberg, Maxence Bigerelle & Karine Anselme

The effect that microscale surface curvature has on cell migration has not been evaluated. Here the authors fabricate sinusoidal 3D surfaces and show that the cell nucleus and cytoskeleton cooperate to guide cells to concave valleys in a process they coin curvotaxis.

28 September 2018 | doi: 10.1038/s41467-018-06494-6
Biomaterials  Cell migration 

Spin-momentum locking and spin-orbit torques in magnetic nano-heterojunctions composed of Weyl semimetal WTe2 OPEN
Peng Li, Weikang Wu, Yan Wen, Chenhui Zhang, Junwei Zhang, Senfu Zhang, Zhiming Yu, Shengyuan A. Yang, A. Manchon & Xi-xiang Zhang

The Fermi arcs, topological surface states of Weyl semimetals can enable the intriguing spin control and facilitate topological spintronics. Here the authors report the spin-orbit torque at the interface of WTe2/Py and attribute it to the enhanced spin accumulation by the spin-momentum locking effect of the Fermi arcs of WTe2.

28 September 2018 | doi: 10.1038/s41467-018-06518-1
Spintronics  Surfaces, interfaces and thin films 

A sustained change in the supply of parental care causes adaptive evolution of offspring morphology OPEN
Benjamin J. M. Jarrett, Emma Evans, Hannah B. Haynes, Miranda R. Leaf, Darren Rebar, Ana Duarte, Matthew Schrader & Rebecca M. Kilner

The amount and predictability of parental care may influence the evolution of offspring traits. Here, the authors experimentally evolve burying beetles at different levels of parental care and find smaller mandibles and lower self-sufficiency in populations with more care.

28 September 2018 | doi: 10.1038/s41467-018-06513-6
Behavioural ecology  Experimental evolution  Social evolution 

An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel OPEN
Arin Marchesi, Xiaolong Gao, Ricardo Adaixo, Jan Rheinberger, Henning Stahlberg, Crina Nimigean & Simon Scheuring

Cyclic nucleotide-gated (CNG) ion channels are non-selective cation channels key to signal transduction, but conformational changes associated with gating remained unknown. Here authors use high-speed atomic force microscopy to visualize SthK channels dynamics in response to cyclic nucleotides.

28 September 2018 | doi: 10.1038/s41467-018-06414-8
Ion transport  Single-molecule biophysics 

Robust quantum valley Hall effect for vortices in an interacting bosonic quantum fluid OPEN
O. Bleu, G. Malpuech & D. D. Solnyshkov

Topologically protected pseudospin transport is difficult to implement for bosonic systems due to the lack of symmetry-protected pseudospins. Here, Bleu et al. propose robust valley pseudospin transport, truly topologically protected by the winding of a quantum vortex propagating between two staggered honeycomb lattices.

28 September 2018 | doi: 10.1038/s41467-018-06520-7
Bose–Einstein condensates  Quantum Hall  Topological defects 

Resonant torsion magnetometry in anisotropic quantum materials OPEN
K. A. Modic, Maja D. Bachmann, B. J. Ramshaw, F. Arnold, K. R. Shirer, Amelia Estry, J. B. Betts, Nirmal J. Ghimire, E. D. Bauer, Marcus Schmidt, Michael Baenitz, E. Svanidze, Ross D. McDonald, Arkady Shekhter & Philip J. W. Moll

Insights into the behavior of quantum materials are only possible because of the development of suitable experimental probes. Modic et. al. develop the theoretical and experimental basis for resonant torsion magnetometry—a technique to measure anisotropic magnetic responses with high sensitivity.

28 September 2018 | doi: 10.1038/s41467-018-06412-w
Magnetic properties and materials  Phase transitions and critical phenomena  Techniques and instrumentation 

Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery OPEN
Hui-Ju Hsieh, Wei Zhang, Shu-Hong Lin, Wen-Hao Yang, Jun-Zhong Wang, Jianfeng Shen, Yiran Zhang, Yiling Lu, Hua Wang, Jane Yu, Gordon B. Mills & Guang Peng

DNA damage induces checkpoints to ensure that damage is not transferred to the next generation, but the molecular pathways responsible for checkpoint recovery are not clear. Here the authors show that the nutrient sensor mTORC1 is a determinant for G2/M checkpoint recovery through regulation of cyclin B1 and PLK1 expression.

28 September 2018 | doi: 10.1038/s41467-018-05639-x
DNA damage checkpoints  Regulatory networks 

Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis OPEN
Ronja Driller, Sophie Janke, Monika Fuchs, Evelyn Warner, Anil R. Mhashal, Dan Thomas Major, Mathias Christmann, Thomas Brück & Bernhard Loll

The bacterial diterpene synthase CotB2 catalyses the cyclisation of geranylgeranyl diphosphate to cyclooctat-9-en7-ol. Here the authors present various CotB2 structures including a trapped abrupt reaction product that were used for molecular dynamic simulations and allowed them to model all intermediates along the reaction cascade.

28 September 2018 | doi: 10.1038/s41467-018-06325-8
Biocatalysis  Enzyme mechanisms  Metabolic engineering  Molecular modelling  Natural product synthesis 

Remote sensing of geomagnetic fields and atomic collisions in the mesosphere OPEN
Felipe Pedreros Bustos, Domenico Bonaccini Calia, Dmitry Budker, Mauro Centrone, Joschua Hellemeier, Paul Hickson, Ronald Holzlöhner & Simon Rochester

Remote sensing of geomagnetic fields in mesosphere is both challenging and interesting to explore the magnetic field structures and atomic collision processes. Here the authors demonstrate an atomic magnetometer that utilizes the Larmor frequency in sodium atoms and operates in kilometers range.

28 September 2018 | doi: 10.1038/s41467-018-06396-7
Atomic and molecular collision processes  Atomic and molecular interactions with photons  Imaging and sensing  Magnetospheric physics 

Intracellular nucleosomes constrain a DNA linking number difference of −1.26 that reconciles the Lk paradox OPEN
Joana Segura, Ricky S. Joshi, Ofelia Díaz-Ingelmo, Antonio Valdés, Silvia Dyson, Belén Martínez-García & Joaquim Roca

There had been an enduring discrepancy between theoretical and observed measurement of the DNA linking number (∆Lk) constrained by nucleosomes. Here the authors provide measurements of the ∆Lk constrained by individual nucleosomes in native chromatin that reconcile this discrepancy.

28 September 2018 | doi: 10.1038/s41467-018-06547-w
Molecular conformation  Nucleosomes 

Superplasticity in an organic crystal OPEN
Satoshi Takamizawa, Yuichi Takasaki, Toshiyuki Sasaki & Noriaki Ozaki

Superplasticity enables processing on hard-to-work solids but superelastic deformation, especially in a single-crystal-to-single-crystal manner, was not demonstrated for organic crystals so far. Here the authors demonstrate a single-crystal-to-single-crystal superplasticity in a crystal of N,N-dimethyl-4-nitroaniline.

28 September 2018 | doi: 10.1038/s41467-018-06431-7
Mechanical properties  Organic molecules in materials science  Structure elucidation 

Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones OPEN
Noah Guy Lewis Guiberson, André Pineda, Debra Abramov, Parinati Kharel, Kathryn E. Carnazza, Rachel T. Wragg, Jeremy S. Dittman & Jacqueline Burré

Munc18-1 is an evolutionary conserved gene whose mutations are linked to various neurological diseases in human. In order to better understand the exact nature of the mutations, the authors here utilize several model systems to show mutant Munc18-1 can aggregate and deplete functional pool of Wt protein, and that chemical chaperones can reverse the cellular deficits.

28 September 2018 | doi: 10.1038/s41467-018-06507-4
Mechanisms of disease  Molecular neuroscience  Proteins 

Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis OPEN
Jonathan Dorival, Fanny Risser, Christophe Jacob, Sabrina Collin, Gerald Dräger, Cédric Paris, Benjamin Chagot, Andreas Kirschning, Arnaud Gruez & Kira J. Weissman

The monoamine oxidase family member LkcE is an enzyme from the lankacidin polyketide biosynthetic pathway, where it catalyzes an amide oxidation followed by an intramolecular Mannich reaction, yielding the polyketide macrocycle. Here the authors characterize LkcE and present several of its crystal structures, which explains the unusual dual activity of LkcE.

28 September 2018 | doi: 10.1038/s41467-018-06323-w
Biosynthesis  Enzyme mechanisms  X-ray crystallography 

Genus-wide sequencing supports a two-locus model for sex-determination in Phoenix OPEN
Maria F. Torres, Lisa S. Mathew, Ikhlak Ahmed, Iman K. Al-Azwani, Robert Krueger, Diego Rivera-Nuñez, Yasmin A. Mohamoud, Andrew G. Clark, Karsten Suhre & Joel A. Malek

The origin and evolution of separate sexes in plants are long-standing questions. Here, the authors use genus-wide sequencing to identify sex determining candidate genes in the genus Phoenix and demonstrate the consistence with the previously proposed two-mutation model.

28 September 2018 | doi: 10.1038/s41467-018-06375-y
Comparative genomics  Fertilization  Plant evolution 

Temporal genetic association and temporal genetic causality methods for dissecting complex networks OPEN
Luan Lin, Quan Chen, Jeanne P. Hirsch, Seungyeul Yoo, Kayee Yeung, Roger E. Bumgarner, Zhidong Tu, Eric E. Schadt & Jun Zhu

Temporal omics data have the potential to dissect complex biological networks. Here the authors develop methods for detecting temporal genetic loci (teQTLs) of quantitative traits monitored over time and inferring causal relationships between traits linked to the locus.

28 September 2018 | doi: 10.1038/s41467-018-06203-3
Data integration  Regulatory networks 

High-resolution NMR studies of antibiotics in cellular membranes OPEN
João Medeiros-Silva, Shehrazade Jekhmane, Alessandra Lucini Paioni, Katarzyna Gawarecka, Marc Baldus, Ewa Swiezewska, Eefjan Breukink & Markus Weingarth

Antibiotics that target the peptidoglycan precursor lipid II are promising templates for next-generation antibiotics. Here authors use solid-state NMR and monitor lipid II-binding antibiotics, such as nisin, directly in cell membranes.

27 September 2018 | doi: 10.1038/s41467-018-06314-x
Antibiotics  Antimicrobial resistance  Molecular medicine  NMR spectroscopy  Structure-based drug design 

Regulatory mechanisms of incomplete huntingtin mRNA splicing OPEN
Andreas Neueder, Anaelle A. Dumas, Agnesska C. Benjamin & Gillian P. Bates

Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.

27 September 2018 | doi: 10.1038/s41467-018-06281-3
Huntington's disease  RNA splicing  Transcription 

Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction OPEN
Atsushi Yamagata, Sakurako Goto-Ito, Yusuke Sato, Tomoko Shiroshima, Asami Maeda, Masahiko Watanabe, Takashi Saitoh, Katsumi Maenaka, Tohru Terada, Tomoyuki Yoshida, Takeshi Uemura & Shuya Fukai

Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Here authors solve the crystal structure of LRRTM2 in complex with its ligand Nrxn1β and shed light on how selective binding of ligands to LRRTM1/2 is achieved.

27 September 2018 | doi: 10.1038/s41467-018-06333-8
Molecular neuroscience  X-ray crystallography 

Uniform doping of graphene close to the Dirac point by polymer-assisted assembly of molecular dopants OPEN
Hans He, Kyung Ho Kim, Andrey Danilov, Domenico Montemurro, Liyang Yu, Yung Woo Park, Floriana Lombardi, Thilo Bauch, Kasper Moth-Poulsen, Tihomir Iakimov, Rositsa Yakimova, Per Malmberg, Christian Müller, Sergey Kubatkin & Samuel Lara-Avila

Incorporating dopants in the graphene lattice to tune its electronic properties is a challenging task. Here, the authors report a strategy to dope epitaxial large-area graphene on SiC by means of spin-coating deposition of F4TCNQ polymers in ambient conditions.

27 September 2018 | doi: 10.1038/s41467-018-06352-5
Electronic devices  Electronic properties and devices  Polymer characterization  Surfaces, interfaces and thin films 

Nuclear lamina dysfunction triggers a germline stem cell checkpoint OPEN
Lacy J. Barton, Tingting Duan, Wenfan Ke, Amy Luttinger, Kaylee E. Lovander, Alexey A. Soshnev & Pamela K. Geyer

Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that healthy gametes are passed on to the next generation.

27 September 2018 | doi: 10.1038/s41467-018-06277-z
DNA damage response  Oogenesis 

Nitrogen availability regulates topsoil carbon dynamics after permafrost thaw by altering microbial metabolic efficiency OPEN
Leiyi Chen, Li Liu, Chao Mao, Shuqi Qin, Jun Wang, Futing Liu, Sergey Blagodatsky, Guibiao Yang, Qiwen Zhang, Dianye Zhang, Jianchun Yu & Yuanhe Yang

Soil nitrogen availability may alter carbon dynamics after permafrost thaw, but experimental evidence for this carbon-nitrogen interaction is still lacking. Here the authors show that elevated post-thaw nitrogen availability inhibits soil carbon release through its enhancement in microbial metabolic efficiency.

27 September 2018 | doi: 10.1038/s41467-018-06232-y
Carbon cycle  Element cycles 

Metal-organic framework patterns and membranes with heterogeneous pores for flow-assisted switchable separations OPEN
Guan-Young Jeong, Ajay K. Singh, Min-Gyu Kim, Ki-Won Gyak, UnJin Ryu, Kyung Min Choi & Dong-Pyo Kim

Tailoring MOFs to allow access of complex and large molecules is a challenging task due to their inherent microporous nature. Here the authors engineer meso- and macroporous MOF patterns and membranes via a mild decarboxylation applicable to different substrates, demonstrating their potential in macromolecule separations.

27 September 2018 | doi: 10.1038/s41467-018-06438-0
Metal–organic frameworks  Organic chemistry  Porous materials 

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells OPEN
Joseph C. Mudd, Kathleen Busman-Sahay, Sarah R. DiNapoli, Stephen Lai, Virginia Sheik, Andrea Lisco, Claire Deleage, Brian Richardson, David J. Palesch, Mirko Paiardini, Mark Cameron, Irini Sereti, R. Keith Reeves, Jacob D. Estes & Jason M. Brenchley

Innate lymphoid cells (ILCs) have been shown to be depleted during HIV-1 infection. Here the authors show that ILC loss is associated with CD4 depletion and gastrointestinal damage in a primate model of SIV infection.

27 September 2018 | doi: 10.1038/s41467-018-05528-3
HIV infections  Innate lymphoid cells  Mucosal immunology  Viral host response 

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome OPEN
Michael Rusch, Joy Nakitandwe, Sheila Shurtleff, Scott Newman, Zhaojie Zhang, Michael N. Edmonson, Matthew Parker, Yuannian Jiao, Xiaotu Ma, Yanling Liu, Jiali Gu, Michael F. Walsh, Jared Becksfort, Andrew Thrasher, Yongjin Li, James McMurry, Erin Hedlund, Aman Patel, John Easton, Donald Yergeau et al.

Clinical oncology is rapidly adopting next-generation sequencing technology for nucleotide variant and indel detection. Here the authors present a three-platform approach (whole-genome, whole-exome, and whole-transcriptome) in pediatric patients for the detection of diverse types of germline and somatic variants.

27 September 2018 | doi: 10.1038/s41467-018-06485-7
Cancer genomics  Genome informatics 

RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis OPEN
Uwe Richter, Molly E. Evans, Wesley C. Clark, Paula Marttinen, Eric A. Shoubridge, Anu Suomalainen, Anna Wredenberg, Anna Wedell, Tao Pan & Brendan J. Battersby

Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the stability of selected nascent chains.

27 September 2018 | doi: 10.1038/s41467-018-06471-z
Mitochondria  RNA modification  Translation 

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases OPEN
Yun Zhang, Shunbin Xiong, Bin Liu, Vinod Pant, Francis Celii, Gilda Chau, Ana C. Elizondo-Fraire, Peirong Yang, Mingjian James You, Adel K. El-Naggar, Nicholas E. Navin & Guillermina Lozano

Mutations in TP53 gene are very common in cancer development. Here the authors take advantage of murine models to show that somatic Trp53 mutations differentially drive breast cancer and evolution of metastases.

27 September 2018 | doi: 10.1038/s41467-018-06146-9
Breast cancer  Cancer models 

Spatial heterogeneity as the structure feature for structure–property relationship of metallic glasses OPEN
Fan Zhu, Shuangxi Song, Kolan Madhav Reddy, Akihiko Hirata & Mingwei Chen

Directly relating the mechanical properties of metallic glasses to their atomic structure remains a challenge. Here, the authors use high resolution microscopy to show many mechanical properties of metallic glasses depend on a single structural parameter, the characteristic length of spatial heterogeneity.

27 September 2018 | doi: 10.1038/s41467-018-06476-8
Glasses  Mechanical properties  Metals and alloys  Structure of solids and liquids 

Nordic Seas polynyas and their role in preconditioning marine productivity during the Last Glacial Maximum OPEN
Jochen Knies, Denizcan Köseoğlu, Leif Rise, Nicole Baeten, Valérie K. Bellec, Reidulv Bøe, Martin Klug, Giuliana Panieri, Patrycja E. Jernas & Simon T. Belt

Polynyas potentially played a role in sustaining marine life during the last glacial, yet their presence and importance remains equivocal. This multi-proxy study reconstructs a corridor of polynyas in the Nordic Seas during the last glacial maximum, and reveals a strong association with biological productivity.

27 September 2018 | doi: 10.1038/s41467-018-06252-8
Carbon cycle  Palaeoclimate 

AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A OPEN
Alexandra K. Davies, Daniel N. Itzhak, James R. Edgar, Tara L. Archuleta, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson & Georg H. H. Borner

Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy through peripheral delivery of ATG9A.

27 September 2018 | doi: 10.1038/s41467-018-06172-7
Autophagy  Mechanisms of disease  Membrane trafficking  Proteomics  Systems biology 

Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy OPEN
Fabio A. Iannotti, Ester Pagano, Ombretta Guardiola, Simone Adinolfi, Valentina Saccone, Silvia Consalvi, Fabiana Piscitelli, Elisabetta Gazzerro, Giuseppe Busetto, Diego Carrella, Raffaele Capasso, Pier Lorenzo Puri, Gabriella Minchiotti & Vincenzo Di Marzo

The regenerative capacity of muscle stem cells is impaired in Duchenne muscular dystrophy (DMD). Here, the authors show that the endocannabinoid receptor CB1 is activated by PAX7 in muscle stem cells, and that pharmacological inhibition of CB1 promotes stem cell activation and ameliorates symptoms in DMD mouse models.

27 September 2018 | doi: 10.1038/s41467-018-06267-1
Lipid signalling  Neuromuscular disease 

A Mendelian randomization study of the effects of blood lipids on breast cancer risk OPEN
Christoph Nowak & Johan Ärnlöv

The link between circulating lipids and breast cancer risk is complex. Here, the authors utilise data from more than 400,000 participants in two-sample Mendelian randomization to assess the link between blood lipids and breast cancer risk, and they find risk-promoting effects of raised LDL-cholesterol and CETP-mediated raised HDL-cholesterol.

27 September 2018 | doi: 10.1038/s41467-018-06467-9
Breast cancer  Cancer epidemiology  Cancer prevention 

Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine OPEN
Yaoqiu Zhu, Elkin L. Romero, Xiaodong Ren, Angel J. Sanca, Congkuo Du, Cai Liu, Zubair A. Karim, Fatima Z. Alshbool, Fadi T. Khasawneh, Jiang Zhou, Dafang Zhong & Bing Geng

Hydrogen sulphide (H2S) is a gaseous signalling molecule, which has shown therapeutic value. Here, the authors show that a thioenol metabolite of the antithrombotic drug clopidogrel is an efficient H2S donor and masked thioenols can be linked to existing compounds to develop H2S-releasing agents.

27 September 2018 | doi: 10.1038/s41467-018-06373-0
Drug discovery and development  Small molecules 
 
Nature Communications
EVENT
AHIMA World Congress (AWC) Healthcare Information Summit
25.10.18
Abdu Dhabi, UAE
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  Latest Correspondence  
 
Premature alarm on the impacts of climate change on Arctic Char in Lake Hazen OPEN
Jean-Sébastien Moore, Jacqueline M. Chapman, Marc J. Mazerolle, Les N. Harris & Eric B. Taylor
28 September 2018 | doi: 10.1038/s41467-018-06479-5
Community ecology  Ecosystem ecology  Freshwater ecology  Population dynamics 
 
  Latest Author Corrections  
 
Author Correction: The identification of carbon dioxide mediated protein post-translational modifications OPEN
Victoria L. Linthwaite, Joanna M. Janus, Adrian P. Brown, David Wong-Pascua, AnnMarie C. O'Donoghue, Andrew Porter, Achim Treumann, David R. W. Hodgson & Martin J. Cann
03 October 2018 | doi: 10.1038/s41467-018-06711-2
Chemical modification  Post-translational modifications  Proteomic analysis 

Author Correction: Multilayer networks reveal the spatial structure of seed-dispersal interactions across the Great Rift landscapes OPEN
Sérgio Timóteo, Marta Correia, Susana Rodríguez-Echeverría, Helena Freitas & Ruben Heleno
02 October 2018 | doi: 10.1038/s41467-018-06669-1
Community ecology  Ecological networks  Tropical ecology 

Author Correction: Dynamically induced cascading failures in power grids OPEN
Benjamin Schäfer, Dirk Witthaut, Marc Timme & Vito Latora
27 September 2018 | doi: 10.1038/s41467-018-06483-9
Complex networks  Energy modelling 
 
  Latest Publisher Corrections  
 
Publisher Correction: Necroptosis mediates myofibre death in dystrophin-deficient mice OPEN
Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni & Maximilien Bencze
02 October 2018 | doi: 10.1038/s41467-018-06636-w
Necroptosis  Skeletal muscle 

Publisher Correction: Critical Southern Ocean climate model biases traced to atmospheric model cloud errors OPEN
Patrick Hyder , John M. Edwards, Richard P. Allan, Helene T. Hewitt, Thomas J. Bracegirdle, Jonathan M. Gregory, Richard A. Wood, Andrew J. S. Meijers, Jane Mulcahy, Paul Field, Kalli Furtado, Alejandro Bodas-Salcedo, Keith D. Williams, Dan Copsey, Simon A. Josey, Chunlei Liu, Chris D. Roberts, Claudio Sanchez, Jeff Ridley, Livia Thorpe et al.
02 October 2018 | doi: 10.1038/s41467-018-06662-8
Atmospheric dynamics  Physical oceanography  Projection and prediction 
 
 

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