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Nature Chemical Biology Contents: November 2018, Volume 14 No 11

Nature Chemical Biology


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TABLE OF CONTENTS

November 2018 Volume 14, Issue 11

Research Highlights
News & Views
Articles

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Research Highlights

No more ESKAPE    p989
Mirella Bucci
doi:10.1038/s41589-018-0156-7

Chaperoning partners    p989
Grant Miura
doi:10.1038/s41589-018-0157-6

Trading on thionoesters    p989
Caitlin Deane
doi:10.1038/s41589-018-0158-5

A new spot for PKR    p989
Yiyun Song
doi:10.1038/s41589-018-0159-4

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News & Views

New tricks for an old drug    pp990 - 991
Barbara S. Nelson, Daniel M. Kremer & Costas A. Lyssiotis
doi:10.1038/s41589-018-0137-x

Parsing protein sulfinic acid switches    pp991 - 993
Sophie Rahuel-Clermont & Michel B. Toledano
doi:10.1038/s41589-018-0151-z

Compartmentalizing acid stress in bacteria    pp993 - 994
Colin Kleanthous
doi:10.1038/s41589-018-0148-7

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Articles

Chemical proteomics reveals new targets of cysteine sulfinic acid reductase    pp995 - 1004
Salma Akter, Ling Fu, Youngeun Jung, Mauro Lo Conte, J. Reed Lawson et al.
doi:10.1038/s41589-018-0116-2

An electrophilic diazene probe (DiaAlk) enables capture and proteomic analysis of cysteine S-sulfinylation modifications, thus illuminating dynamic responses to oxidative stress and enabling the identification of new substrates of sulfiredoxin.

Metabolic repair through emergence of new pathways in Escherichia coli    pp1005 - 1009
Sammy Pontrelli, Riley C. B. Fricke, Shao Thing Teoh, Walter A. Laviña, Sastia Prama Putri et al.
doi:10.1038/s41589-018-0149-6

In response to the deletion of key genes involved in biosynthesis of the essential CoA precursor β-alanine, Escherichia coli overcomes this pathway damage by successively evolving alternative metabolic pathways.

Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis    pp1010 - 1020
Takaaki Taniguchi, Kenjyo Miyauchi, Yuriko Sakaguchi, Seisuke Yamashita, Akiko Soma et al.
doi:10.1038/s41589-018-0119-z

A comparative genomic approach identified a novel acetate-dependent tRNA-modifying enzyme that catalyzes RNA acetylation with a mechanism similar to tRNA aminoacylation. This modification maintains decoding fidelity in protein synthesis.

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues    pp1021 - 1031
Martina Wallace, Courtney R. Green, Lindsay S. Roberts, Yujung Michelle Lee, Justin L. McCarville et al.
doi:10.1038/s41589-018-0132-2

mmBCFAs are endogenous fatty acids synthesized from BCAAs by brown and white adipose tissue via CrAT and FASN promiscuity. BCAA catabolism and mmBCFA lipogenesis are decreased by obesity-induced adipose hypoxia and influenced by the microbiome.

MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG    pp1032 - 1042
Louise Fets, Paul C. Driscoll, Fiona Grimm, Aakriti Jain, Patrícia M. Nunes et al.
doi:10.1038/s41589-018-0136-y

High intracellular concentrations of the α-ketoglutarate analog N-oxalylglycine, owing to MCT2-mediated transport of its newly described prodrug MOG, inhibit multiple enzymes in glutamine metabolism and selectively kill MCT2-expressing cancer cells.

Small-molecule-based regulation of RNA-delivered circuits in mammalian cells    pp1043 - 1050
Tyler E. Wagner, Jacob R. Becraft, Katie Bodner, Brian Teague, Xin Zhang et al.
doi:10.1038/s41589-018-0146-9

Engineering of small-molecule-responsive RNA-binding proteins enables chemical regulation of modified mRNA or RNA replicon expression within mammalian cells for applications in synthetic circuit design and RNA-centered therapeutics.

In vivo chloride concentrations surge to proteotoxic levels during acid stress    pp1051 - 1058
Frederick Stull, Hannah Hipp, Randy B. Stockbridge & James C. A. Bardwell
doi:10.1038/s41589-018-0143-z

Protonation of periplasmic protein carboxylic groups creates a Donnan equilibrium in the bacterial periplasmic space at low pH, leading to accumulation of Cl and unfolding and aggregation of periplasmic proteins, which can be rescued by chaperones.

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist    pp1059 - 1066
Matthieu Masureel, Yaozhong Zou, Louis-Philippe Picard, Emma van der Westhuizen, Jacob P. Mahoney et al.
doi:10.1038/s41589-018-0145-x

The active-state structure of a GPCR occupied by a partial agonist, β2AR with salmeterol, together with mutagenesis and biophysical studies, explains this ligand's unusual pharmacological profile.

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