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Nature Cell Biology contents: November 2018 Volume 20 Number 11

Nature Cell Biology

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November 2018 Volume 20, Issue 11

News & Views
Review Articles
Technical Reports
Amendments & Corrections

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The challenge of the post-truth era    p1231

News & Views

CRAD as a cytoskeletal tumour suppressor    pp1232 - 1233
George Eng, Jonathan Braverman & Ömer H. Yilmaz

Atypical matrix adhesions guide cell division    pp1233 - 1235
Ronen Zaidel-Bar

CRISPR mutagenesis screening of mice    pp1235 - 1237
Yevgeniy V. Serebrenik & Ophir Shalem

Differentiation keeps skin cancer at bay    pp1237 - 1239
Paola Kuri & Panteleimon Rompolas

Nature Cell Biology
Metabolism in Cancer and Stromal Cells (2nd edition)
Leuven, Belgium
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Review Articles

Dormant tumour cells, their niches and the influence of immunity    pp1240 - 1249
Erica T. Goddard, Ivana Bozic, Stanley R. Riddell & Cyrus M. Ghajar

Goddard et al review recent advances in our understanding of dormant tumour cells, highlight their cross-talk with immune responses, and elaborate therapeutic implications to treat metastatic malignancies.


The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia    pp1250 - 1255
Mareike A. Jordan, Dennis R. Diener, Ludek Stepanek & Gaia Pigino

Opposing kinesin-2 and dynein-1b motors drive IFT bidirectionally along microtubules. Using cryo-electron tomography, Jordan et al. uncover mechanisms of dynein-1 inhibition to promote unidirectional IFT to the ciliary tip.


Oncogenic activation of PI3K induces progenitor cell differentiation to suppress epidermal growth    pp1256 - 1266
Zhe Ying, Madeline Sandoval & Slobodan Beronja

Ying et al. show that oncogenic PI3K–AKT activation, through the suppression of SH3RF1, induces epidermal differentiation, inhibits progenitor self-renewal and prevents tumour initiation.

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells    pp1267 - 1277
Valentina Cigliola, Luiza Ghila, Fabrizio Thorel, Léon van Gurp, Delphine Baronnier et al.

Cigliola et al. show that β-cell loss activates insulin production in a small number of α-cells and that insulin and Hedgehog signalling actively maintain and enforce the α-cell fate.

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation    pp1278 - 1289
Neophytos Christodoulou, Christos Kyprianou, Antonia Weberling, Ran Wang, Guizhong Cui et al.

Using time-lapse microscopy and transcriptome analysis of the post-implantation mouse embryo, Christodoulou et al. show that cavity fusion occurs through the formation and polarized resolution of multiple, multicellular three-dimensional rosettes.

Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis    pp1290 - 1302
John G. Lock, Matthew C. Jones, Janet A. Askari, Xiaowei Gong, Anna Oddone et al.

Lock et al. identify reticular adhesion complexes that maintain cell–extracellular-matrix attachments during cell division. Reticular adhesions transmit spatial memory between cell generations, mediated by αvβ5 integrin and PtdIns(4,5)P2.

Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin    pp1303 - 1314
Youn-Sang Jung, Wenqi Wang, Sohee Jun, Jie Zhang, Mrinal Srivastava et al.

Jung et al. demonstrate that loss of CRAD impairs F-actin polymerization and disrupts the cadherin–catenin–actin complex, thereby hyperactivating Wnt signalling and promoting mucinous intestinal tumorigenesis.

Technical Reports

CRISPR–Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development    pp1315 - 1325
Qing Li, Yanjing Li, Suming Yang, Shuo Huang, Meng Yan et al.

Li and colleagues develop a CRISPR–Cas9-based screen strategy that combines base editing and haploid embryonic stem cell technologies to identify amino acids critical for protein function in mice.

Amendments & Corrections

Author Correction: Topoisomerase IIα controls the decatenation checkpoint    pp1326 - 1327
Kuntian Luo, Jian Yuan, Junjie Chen & Zhenkun Lou

Author Correction: AMP kinase promotes glioblastoma bioenergetics and tumour growth    p1328
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang et al.

Retraction Note: Formin' a perinuclear actin cage in confined migration    p1328
Alexia-Ileana Zaromytidou

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