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zaterdag 22 september 2018

The Lancet: [Comment] Juvenile Huntington's disease: left behind?

[Comment] Juvenile Huntington's disease: left behind?
Most movement disorders specialists will care for only a handful of children with juvenile Huntington's disease (onset at age 20 years or younger) during a lifetime of clinical practice. Therefore, the retrospective study of 36 children and adolescents with juvenile Huntington's disease reported by Caterina Fusilli and colleagues1 in The Lancet Neurology is extraordinary because this sample size, which is large considering the low prevalence rate, provides a rich opportunity to examine key features of juvenile Huntington's disease.
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[Corrections] Corrections
Al-Shahi Salman R, Frantzias J, Lee RJ, et al. Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data. Lancet Neurol 2018; 17: 885–94—The affiliation of Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany has been added for authors Dimitre Staykov and Bastian Volbers. This correction has been made to the online version as of Sept 19, 2018.
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[Review] Nutrition and prevention of cognitive impairment
Nutrition is an important lifestyle factor that can modify the risk of future cognitive impairment and dementia. Some, but not conclusive, evidence (mostly from observational studies and infrequently from clinical trials) exists of a protective association between certain nutrients (eg, folate, flavonoids, vitamin D, and certain lipids) or food groups (eg, seafood, vegetables, and fruits, and potentially moderate alcohol and caffeine consumption) and cognitive outcomes in older people. For some nutrients and food groups, protection might be greater in individuals with either deficiencies in certain nutrients or a genetic predisposition to cognitive impairment.
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[Review] Comorbidities, treatment, and pathophysiology in restless legs syndrome
Restless legs syndrome, also known as Willis-Ekbom disease, is a common neurological condition whose manifestation is affected by complex environmental and genetic interactions. Restless legs syndrome can occur on its own, mostly at a young age, or with comorbidities such as cardiovascular disease, diabetes, and arterial hypertension, making it a difficult condition to properly diagnose. However, the concept of restless legs syndrome as being two entities, primary or secondary to another condition, has been challenged with genetic data providing further insight into the pathophysiology of the condition.
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[In Context] The science of today is all about tomorrow
Perhaps some remember science lessons at school as intimidating, or even boring, associated with something out of reach: esoteric or mysterious. Making science relevant, meaningful, or accessible to the non-scientist is important if you want to engage "the ordinary visitor", a term used by the previous director of what is now known as the Science Museum (London, UK), Colonel Sir Henry Lyons. So, in 1931, he opened a Children's Gallery to demonstrate scientific principles in a fun format, in today's parlance—hands-on and interactive.
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