We bring you the latest news from the healthcare about the health care in the United Kingdom.

maandag 3 september 2018

The Lancet: [Comment] Are ultra-sensitive molecular tools needed to detect malaria transmitters?

[Comment] Are ultra-sensitive molecular tools needed to detect malaria transmitters?
Wide-scale deployment of malaria control interventions has resulted in a global reduction in malaria.1 As countries approach elimination, the focus of control programmes is shifting from a reduction in morbidity and mortality to all-case detection activities designed to interrupt transmission.2,3 In low-endemic settings, where Plasmodium species infections are often asymptomatic, and thus constituting a large reservoir for continued malaria transmission, detection of low-density (submicroscopic) parasite infections is crucial.
Read more

[Review] Quantifying drivers of antibiotic resistance in humans: a systematic review
Mitigating the risks of antibiotic resistance requires a horizon scan linking the quality with the quantity of data reported on drivers of antibiotic resistance in humans, arising from the human, animal, and environmental reservoirs. We did a systematic review using a One Health approach to survey the key drivers of antibiotic resistance in humans. Two sets of reviewers selected 565 studies from a total of 2819 titles and abstracts identified in Embase, MEDLINE, and Scopus (2005–18), and the European Centre for Disease Prevention and Control, the US Centers for Disease Control and Prevention, and WHO (One Health data).
Read more

[Articles] Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study
IGRA-based or BCG-stratified TST strategies appear most suited to screening for potential disease progression among high-risk groups. Further work will be needed to assess country-specific cost-effectiveness of each screening test, and in the absence of highly specific diagnostic tests, cheap non-toxic treatments need to be developed that could be given to larger groups of people at potential risk.
Read more

[Comment] Predicting tuberculosis: the blood, the skin, or the Sibyl?
In The Lancet Infectious Diseases, Ibrahim Abubakar and colleagues1 report the results of the UK PREDICT tuberculosis cohort study, which compared the prognostic value of two interferon-γ release assays (IGRAs) and a tuberculin skin test (TST) in predicting the development of active tuberculosis among high-risk individuals who were not undergoing preventive treatment. The study's large prospective cohort of 9610 eligible participants, recruited from 54 UK National Health Service (NHS) centres and community settings, comprised recent contacts of active tuberculosis (4861 [50·6%]) and migrants who entered the UK within the past 5 years from countries with a high incidence of tuberculosis (4749 [49·4%]).
Read more

[Corrections] Corrections
Nellums LB, Friedland JS, Hargreaves S. Antimicrobial resistance among migrants in Europe—Authors' reply. Lancet Infect Dis 2018; 18: 945—The author list of this Correspondence should read "Laura B Nellums, Jon S Friedland, *Sally Hargreaves". This correction has been made to the online version as of Sept 3, 2018.
Read more