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woensdag 26 september 2018

The Lancet: [Articles] Antibody persistence after vaccination of adolescents with monovalent and combined acellular p...

[Articles] Antibody persistence after vaccination of adolescents with monovalent and combined acellular pertussis vaccines containing genetically inactivated pertussis toxin: a phase 2/3 randomised, controlled, non-inferiority trial
A monovalent and a combined recombinant acellular pertussis vaccine containing PTgen induced antibody responses that were greater and sustained for longer than those achieved with the Tdap comparator vaccine. New recombinant pertussis vaccines containing PTgen might offer new opportunities to limit pertussis resurgence and can be widely used, including in pregnant women.
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[Comment] Genetically modified pertussis toxin: a quantum leap?
Vaccines containing formalin-inactivated whole-cell Bordetella pertussis strains were first developed in the USA in the 1930s, and manufacturing processes were standardised in 1947. From the mid-1950s, whole-cell vaccines were combined with diphtheria and tetanus toxoids, but frequent systemic and local reactions and variability in effectiveness led to declining uptake in Europe and Japan. In the USA, litigation was brought against manufacturers, leading to development of more purified acellular vaccines in the 1980s.
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[Articles] Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016
The health burden of bacterial diarrhoeal pathogens is difficult to estimate. Despite existing prevention and treatment options, they remain a major cause of morbidity and mortality globally. Additional emphasis by public health officials is needed on a reduction in disease due to shigella and ETEC to reduce disease burden.
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[Comment] Estimating the true burden of an enteric pathogen: enterotoxigenic Escherichia coli and Shigella spp
Global estimates of the importance of specific microbes as causes of childhood diarrhoea deaths and illnesses have been done to guide disease control programmes and investments in new technologies, especially vaccines.1,2 In their Article published in The Lancet Infectious Diseases, Ibrahim Khalil and colleagues3 use modelling at the global, regional, and country level to estimate diarrhoeal mortality and incidence in 2016, by age and sex, for enterotoxigenic Escherichia coli (ETEC) and Shigella spp.
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[Articles] The temporal relationship between onchocerciasis and epilepsy: a population-based cohort study
Individual O volvulus MFD in childhood was associated with the risk of either seizures or epilepsy in an onchocerciasis focus in Cameroon. This temporal relationship suggests a potential causal link between onchocerciasis and epilepsy.
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