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vrijdag 14 september 2018

The EMBO Journal Table of Contents for 14 September 2018; Vol. 37, No. 18

IMJ18-01  
14 September 2018 | Volume 37, Number 18 Submit


Table of Contents

News & Views
Review
Articles
Resource
COVER

Volume 37, Number 18



News & Views
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A tRNA modification needed for efficient translation requires the diet‐supplied precursor queuine and its depletion activates cellular stress responses in mice.

Itamar Kozlovski and Reuven Agami
Published online 03.09.2018

Review
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A comprehensive overview of the interplay between synaptic dysfunction and neurodegeneration in Parkinson's disease details the roles of disease‐associated regulators of protein homeostasis, endocytosis and autophagy in synaptic homeostasis.

Sandra‐Fausia Soukup, Roeland Vanhauwaert and Patrik Verstreken
Published online 31.07.2018

Articles
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By inserting an artificial polyadenylation site in vivo, this study shows that expression of a specific lncRNA is required for local chromatin organisation and normal cardiac development.

Monica Ballarino, Andrea Cipriano, Rossella Tita, Tiziana Santini, Fabio Desideri, Mariangela Morlando, Alessio Colantoni, Claudia Carrieri, Carmine Nicoletti, Antonio Musarò, Dònal O’ Carroll and Irene Bozzoni
Published online 03.09.2018 Open Access

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Queuosine modification of tRNAs requires the diet‐supplied precursor queuine. Q‐bearing tRNAs control translational speed, illustrating how a nutritionally determined tRNA modification can affect polypeptide synthesis and cellular homeostasis in vivo.

Francesca Tuorto, Carine Legrand, Cansu Cirzi, Giuseppina Federico, Reinhard Liebers, Martin Müller, Ann E Ehrenhofer‐Murray, Gunnar Dittmar, Hermann‐Josef Gröne and Frank Lyko
Published online 09.08.2018 Open Access

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Proteomic interaction and CRISPR/Cas9 doxorubicin sensitivity screens identify the sought‐after effectors through which the 53BP1/RIF1/REV7 axis antagonizes DNA break resection and promotes non‐homologous end‐joining repair.

Steven Findlay, John Heath, Vincent M Luo, Abba Malina, Théo Morin, Yan Coulombe, Billel Djerir, Zhigang Li, Arash Samiei, Estelle Simo‐Cheyou, Martin Karam, Halil Bagci, Dolev Rahat, Damien Grapton, Elise G Lavoie, Christian Dove, Husam Khaled, Hellen Kuasne, Koren K Mann, Kathleen Oros Klein, Celia M Greenwood, Yuval Tabach, Morag Park, Jean‐Francois Côté, Jean‐Yves Masson, Alexandre Maréchal and Alexandre Orthwein
Published online 28.08.2018 Open Access

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The Zika virus promotes NLRP3 inflammasome activation by stabilizing caspase‐1 to suppress cGAS‐mediated type I IFN signaling.

Yanyan Zheng, Qingxiang Liu, Yaoxing Wu, Ling Ma, Zhenzhen Zhang, Tao Liu, Shouheng Jin, Yuanchu She, Yi‐Ping Li and Jun Cui
Published online 31.07.2018

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Proteomic identification of the Cul5 ubiquitin ligase adaptor Elongin C as AMBRA1‐binding substrate of Cul4 ligase exemplifies crosstalk between cullin‐RING E3s that can modulate both cytokine signaling and HIV‐1 infectivity.

Si‐Han Chen, Gwendolyn M Jang, Ruth Hüttenhain, David E Gordon, Dan Du, Billy W Newton, Jeffrey R Johnson, Joseph Hiatt, Judd F Hultquist, Tasha L Johnson, Yi‐Liang Liu, Lily A Burton, Jordan Ye, Kurt M Reichermeier, Robert M Stroud, Alexander Marson, Jayanta Debnath, John D Gross and Nevan J Krogan
Published online 30.08.2018

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DCAF13 is a novel CRL4 ubiquitin ligase adaptor that is essential for early embryonic nuclear reprogramming.

Yin‐Li Zhang, Long‐Wen Zhao, Jue Zhang, Rongrong Le, Shu‐Yan Ji, Chuan Chen, Yawei Gao, Dali Li, Shaorong Gao and Heng‐Yu Fan
Published online 14.08.2018

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A tripartite motif‐containing ubiquitin ligase modifies the p62‐NRF2 complex for stress‐induced protein aggregation and provides an assembly scaffold for autophagy factors involved in aggregate clearance.

Kautilya Kumar Jena, Srinivasa Prasad Kolapalli, Subhash Mehto, Parej Nath, Biswajit Das, Pradyumna Kumar Sahoo, Abdul Ahad, Gulam Hussain Syed, Sunil K Raghav, Shantibhusan Senapati, Swati Chauhan and Santosh Chauhan
Published online 24.08.2018 Open Access

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The piRNA pathway represses retrotransposons during early development. Base‐pairing between nascent RNA and piRNAs bound by mouse Piwi protein MIWI2 determines the specificity of suppressive DNA methylation.

Toshiaki Watanabe, Xiekui Cui, Zhongyu Yuan, Hongying Qi and Haifan Lin
Published online 14.08.2018

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A yeast Snf2‐family DNA translocase promotes cohesin loading near stalled forks to facilitate sister chromatid template use for the bypass of replication‐blocking DNA damage.

Ireneusz Litwin, Tomasz Bakowski, Barnabas Szakal, Ewa Pilarczyk, Ewa Maciaszczyk‐Dziubinska, Dana Branzei and Robert Wysocki
Published online 14.08.2018

Resource
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Direct recombination of pre‐arranged human B‐cell receptor into the native immunoglobulin locus in fertilized mouse oocytes provides a facile strategy for obtaining vaccination models for infectious disease.

Ying‐Cing Lin, Simone Pecetta, Jon M Steichen, Sven Kratochvil, Eleonora Melzi, Johan Arnold, Stephanie K Dougan, Lin Wu, Kathrin H Kirsch, Usha Nair, William R Schief and Facundo D Batista
Published online 07.08.2018

 
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