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Nature Structural & Molecular Biology Contents: 2018 Volume #25 pp 745 - 902

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Nature Structural & Molecular Biology

Breakthrough K3 Result - A  2.7 Å structure of the 20S Proteasome was made possible with the K3 camera and Elsa cryo-holder on a TF20.

With best-in-class cameras, holders, and software, Gatan continues to set new benchmarks in high-performance, low-dose imaging in electron microscopy.

Learn more about the K3 direct detection camera, Elsa cryo-transfer holder, and Latitude software.

September 2018 Volume 25, Issue 9

Meeting Reports
Review Articles
Technical Reports
Amendments & Corrections
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Dynamics and interactions of AAC3 in DPC are not functionally relevant    pp745 - 747
Vilius Kurauskas, Audrey Hessel, François Dehez, Christophe Chipot, Beate Bersch et al.

Concerns with yeast mitochondrial ADP/ATP carrier’s integrity in DPC     pp747 - 749
Martin S. King, Paul G. Crichton, Jonathan J. Ruprecht & Edmund R. S. Kunji

Reply to ‘Concerns with yeast mitochondrial ADP/ATP carrier’s integrity in DPC’ and ‘Dynamics and interactions of AAC3 in DPC are not functionally relevant’    pp749 - 750
Qin Yang, Sven Brüschweiler, Linlin Zhao & James J. Chou

Meeting Reports


A mighty stream of membrane proteins    pp751 - 753
Chris Miller

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Review Articles


Structural basis of mitochondrial transcription    pp754 - 765
Hauke S. Hillen, Dmitry Temiakov & Patrick Cramer

Cramer and colleagues review and discuss how the structural elucidation of transcription factors and functional complexes of human mitochondrial RNA polymerase have informed emerging understanding of the mechanism of mitochondrial gene transcription.




Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters    pp766 - 777
Natasha Jansz, Andrew Keniry, Marie Trussart, Heidi Bildsoe, Tamara Beck et al.

In situ Hi-C and other genome-wide and imaging analyses in different mouse embryonic cell types reveal that the noncanonical SMC protein Smchd1 regulates long-range chromatin interactions and the developmental silencing of Hox genes.


Terminal uridylyltransferases target RNA viruses as part of the innate immune system    pp778 - 786
Jérémie Le Pen, Hongbing Jiang, Tomás Di Domenico, Emma Kneuss, Joanna Kosałka et al.

A screen for C. elegans antiviral-defense genes identifies a homolog of the mammalian TUT4(7) terminal uridylyltransferase genes and leads to the discovery of 3′-terminal uridylation of viral RNAs as a conserved antiviral defense mechanism.


Structural determinants of 5-HT2B receptor activation and biased agonism     pp787 - 796
John D. McCorvy, Daniel Wacker, Sheng Wang, Bemnat Agegnehu, Jing Liu et al.

Four crystal structures of the human serotonin receptor 5-HT2BR in complex with chemically and pharmacologically diverse drugs elucidate the structural bases for receptor activation, agonist-mediated biased signaling and β-arrestin2 translocation.


Cryo-EM structures of the human volume-regulated anion channel LRRC8    pp797 - 804
Go Kasuya, Takanori Nakane, Takeshi Yokoyama, Yanyan Jia, Masato Inoue et al.

Cryo-EM analyses of human LRRC8A show a homohexameric assembly that can adopt two conformations, compact or relaxed, indicating rigid-body motions that might be involved in channel gating.


Structure and gating mechanism of the transient receptor potential channel TRPV3    pp805 - 813
Appu K. Singh, Luke L. McGoldrick & Alexander I. Sobolevsky

The cryo-electron microscopy structures of the mouse TRPV3 channel, in the closed apo and agonist-bound open conformations, provide insights into the mechanism of activation.


A dynamic three-step mechanism drives the HIV-1 pre-fusion reaction    pp814 - 822
Maro Iliopoulou, Rory Nolan, Luis Alvarez, Yasunori Watanabe, Charles A. Coomer et al.

The interactions between HIV-1 Env and host cell receptors CD4 and CCR5 or CXCR4 are examined using direct stochastic optical reconstruction microscopy and fluorescence fluctuation spectroscopy imaging, revealing a dynamic three-step process leading to formation of the pre-fusion complex.


The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling    pp823 - 832
Kilian R. Knoll, Sebastian Eustermann, Vanessa Niebauer, Elisa Oberbeckmann, Gabriele Stoehr et al.

X-ray crystal structures and mutational analysis of the Arp8 module of the yeast chromatin remodeler INO80 reveal its function as a linker DNA sensor required for nucleosome positioning.


RNA polymerase II clustering through carboxy-terminal domain phase separation    pp833 - 840
Marc Boehning, Claire Dugast-Darzacq, Marija Rankovic, Anders S. Hansen, Taekyung Yu et al.

In vitro assays and high-resolution microscopy show that Pol II CTD undergoes length-dependent liquid phase separation and controls Pol II clustering and mobility in human cells.


The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3    pp841 - 849
Yi Zhang, Yongming Xue, Jiejun Shi, JaeWoo Ahn, Wenyi Mi et al.

Structural and biochemical analyses identify the ZZ domain of p300 as a novel histone H3–binding module that promotes p300 chromatin association and is required for selective acetylation of H3K18 and H3K27 in human cells.


Structure of the mechanosensitive OSCA channels    pp850 - 858
Mingfeng Zhang, Dali Wang, Yunlu Kang, Jing-Xiang Wu, Fuqiang Yao et al.

Cryo-EM and electrophysiological studies of two mechanosensitive OSCA channels from Arabidopsis thaliana reveal their structural similarity to osmosensitive TMEM16 channels and suggest they are gated by force from lipid in response to osmotic stress.


Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1    pp859 - 867
Miki Jishage, Xiaodi Yu, Yi Shi, Sai J. Ganesan, Wei-Yi Chen et al.

Structural, biochemical, and modeling studies reveal how the non-canonical RNA Pol II subunit Gdown1 precludes general transcription factor interactions with Pol II(G) to repress transcriptional activity in the absence of Mediator.


Reconstitution of anaphase DNA bridge recognition and disjunction    pp868 - 876
Kata Sarlós, Andreas S. Biebricher, Anna H. Bizard, Julia A. M. Bakx, Anna G. Ferreté-Bonastre et al.

Single-molecule and biochemistry approaches are used to investigate how ultra-fine DNA bridges, which form between sister chromatids during anaphase, are recognized and processed by cellular factors PICH, BLM, TopoIIIα and RPA.


A single XLF dimer bridges DNA ends during nonhomologous end joining    pp877 - 884
Thomas G. W. Graham, Sean M. Carney, Johannes C. Walter & Joseph J. Loparo

Single-molecule imaging of nonhomologous end joining in Xenopus egg extract reveals that a single XLF dimer aligns broken DNA ends for ligation.


Influenza virus infection causes global RNAPII termination defects    pp885 - 893
Nan Zhao, Vittorio Sebastiano, Natasha Moshkina, Nacho Mena, Judd Hultquist et al.

Influenza A virus (IAV) infection induces transcription termination defects in host cells, an effect modulated by SUMOylation of an intrinsically disordered region of the influenza NS1 protein expressed by the 1918 pandemic IAV strain.


Technical Reports


Genome-wide measurement of local nucleosome array regularity and spacing by nanopore sequencing    pp894 - 901
Sandro Baldi, Stefan Krebs, Helmut Blum & Peter B. Becker

A new approach to map nucleosome array regularity and spacing reveals modulation of array regularity and nucleosome repeat length depending on functional chromatin states.


Amendments & Corrections


Author Correction: Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3    p902
Navid Paknejad & Richard K. Hite

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