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donderdag 27 september 2018

Nature Reviews Immunology Contents October 2018 Volume 18 Number 10 pp 597-659

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Nature Reviews Immunology

Announcing The Global Grants for Gut Health

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October 2018 Volume 18, Issue 10

Research Highlights


From the Human Cell Atlas to dynamic immune maps in human disease   
Lorenz Adlung & Ido Amit

pp597 - 598 | doi:10.1038/s41577-018-0050-2
Scientists involved in the Human Cell Atlas Project describe its potential as a resource for future research and the challenges that lie ahead.
Full Text | PDF


Research Highlights

T cells home in on brain cancer
Yvonne Bordon

p599 | doi:10.1038/s41577-018-0069-4
T cells are engineered to home specifically to brain tumours.

Baby steps for the immune system
Yvonne Bordon

pp600 - 601 | doi:10.1038/s41577-018-0062-y
Infant immune systems are highly diverse at birth but then show convergence in the first three months of life.

T cells under starter’s orders
Kirsty Minton

pp600 - 601 | doi:10.1038/s41577-018-0067-6
Naive CD4+ T cells are prepared for rapid activation and metabolic remodelling through the derepression of a poised translational machinery, which occurs independently of nutrient-sensing pathways.

An avian foundation for dominant tolerance
Adrian Liston

p601 | doi:10.1038/s41577-018-0053-z
Adrian Liston describes two papers by Nicole Le Douarin and colleagues from the 1980s that used a chick–quail graft system to show the existence of dominant T cell tolerance.

Studying tumour-specific T cell responses in 3D
Kirsty Minton

pp602 - 603 | doi:10.1038/s41577-018-0058-7
Autologous T cell–tumour organoid co-cultures provide a minimally invasive method to study patient-specific antitumour immune responses.

Asthma exacerbated by neutrophil ghosts
Lucy Bird

pp602 - 603 | doi:10.1038/s41577-018-0059-6
Neutrophil cytoplasts promote T helper 17 cell responses that propagate neutrophilic inflammation in severe asthma.

Bacteria-primed T cells identified as culprit in glaucoma
Alexandra Flemming

p603 | doi:10.1038/s41577-018-0063-x
Bacterially primed T cells reactive against heat shock proteins enter the eye and cause neurodegeneration in glaucoma.

Nature Reviews Immunology
Immunogenicity and Bioassay Summit 2018
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CAR T cells for infection, autoimmunity and allotransplantation   
Colby R. Maldini, Gavin I. Ellis & James L. Riley

pp605 - 616 | doi:10.1038/s41577-018-0042-2
This Review explores the challenges and opportunities of taking CARs down new therapeutic roads, in terms of developing chimeric antigen receptors (CARs) for treating infectious disease, autoimmunity and transplant rejection.
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Histone deacetylase function in CD4+ T cells   
Wilfried Ellmeier & Christian Seiser

pp617 - 634 | doi:10.1038/s41577-018-0037-z
Histone deacetylases (HDACs) and histone acetyltransferases mediate reversible acetylation of histones and many other non-histone proteins to regulate gene expression and protein function. Here, the authors describe the myriad activities of HDACs in CD4+ T cells and the potential use of HDAC inhibitors as therapeutics for immune-mediated diseases.
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CD4+ T cell help in cancer immunology and immunotherapy   
Jannie Borst, Tomasz Ahrends, Nikolina Bąbała, Cornelis J. M. Melief & Wolfgang Kastenmüller

pp635 - 647 | doi:10.1038/s41577-018-0044-0
CD4+ T cells provide help to CD8+ T cells via lymph node-resident dendritic cells. In this Review, the authors discuss the molecular nature of help signals and how they can be harnessed to improve cancer immunotherapy.
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Biology and regulation of IL-2: from molecular mechanisms to human therapy   
Rosanne Spolski, Peng Li & Warren J. Leonard

pp648 - 659 | doi:10.1038/s41577-018-0046-y
IL-2 is well known for its crucial role in driving T cell responses. Now, with improved knowledge of its expression, signalling and regulation, the therapeutic potential of administering or inhibiting IL-2 is being explored to treat autoimmune diseases, infectious diseases and cancer.
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