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woensdag 26 september 2018

Nature Reviews Cancer contents October 2018 Volume 18 Number 10

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Nature Reviews Cancer

Advance Your Cancer Research Through ATP Production Dynamics

Learn how the Agilent Seashore XF Real-Time ATP rate assay can be used to:
  • Understand metabolic mechanisms driving cancer cell behavior/function.
  • Quantify ATP production rates from glycolysis and mitochondrial respiration in live cells in real time.
  • Characterize fuel dependencies in cancer cells.
Download Poster.

October 2018 Volume 18, Issue 10

Research Highlights
Amendments & Corrections
Meet the shortlist!

The shortlist for this year's Nature Research Awards for Inspiring Science and Innovating Science has been announced. These Awards showcase exceptional achievements of leading women in science and of those who have encouraged girls and women to engage with STEM subjects.

See more about our shortlisted nominees >

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Research Highlights

Changing mutational patterns
Sarah Seton-Rogers

p597 | doi:10.1038/s41568-018-0058-8
Lee, Adler et al. show that urea cycle dysregulation is common in cancer and leads to a purine to pyrimidine mutational bias that is associated with a better response to immune checkpoint inhibitors.

Epigenetic control by sugar
Ulrike Harjes

pp598 - 599 | doi:10.1038/s41568-018-0052-1
A recent study, published in Nature, identifies the methylcytosine dioxygenase 2 (TET2) as an epigenetic modifier that is regulated in response to glucose availability and mechanistically links higher cancer susceptibility in patients with diabetes to high blood glucose levels.

In search of missing T cells
Isobel Leake

pp598 - 599 | doi:10.1038/s41568-018-0055-y

Leukaemic escape routes
Anna Dart

p599 | doi:10.1038/s41568-018-0051-2
Yao et al. have established that acute lymphoblastic leukaemia cells bypass the need to metastasize via the circulation to the CNS and instead use a direct route migrating along the vascular channels that bridge the bone marrow to the meninges in an α6 integrin-dependent manner.

Nature Reviews Cancer
6th International Oncology Conference
Abu Dhabi, UAE
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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment   
Francesco Di Virgilio, Alba Clara Sarti, Simonetta Falzoni, Elena De Marchi & Elena Adinolfi

pp601 - 618 | doi:10.1038/s41568-018-0037-0
In this Review, Di Virgilio et al. describe how extracellular ATP and P2 purinergic signalling can shape the tumour microenvironment to both promote and restrain tumour progression and outline the opportunities to harness nucleotide receptor signalling as an anticancer strategy.
Full Text | PDF
Collection: Cancer at Nature Research

Nutrient scavenging in cancer   
Brendan T. Finicle, Vaishali Jayashankar & Aimee L. Edinger

pp619 - 633 | doi:10.1038/s41568-018-0048-x
This Review discusses nutrient scavenging, a process by which cancer cells use macromolecules from their environment to fuel cell metabolism and growth even when nutrients are limiting.
Full Text | PDF
Collection: Cancer at Nature Research

Rewiring urea cycle metabolism in cancer to support anabolism   
Rom Keshet, Peter Szlosarek, Arkaitz Carracedo & Ayelet Erez

pp634 - 645 | doi:10.1038/s41568-018-0054-z
This Review discusses the reprogramming of the urea cycle, the main metabolic liver pathway for nitrogen disposal, in cancer cells. The authors provide insight into the metabolic advantages and therapeutic opportunities stemming from urea cycle enzyme perturbations in cancer.
Full Text | PDF
Collection: Cancer at Nature Research

Cancer in wildlife: patterns of emergence   
Patricia A. Pesavento, Dalen Agnew, Michael K. Keel & Kevin D. Woolard

pp646 - 661 | doi:10.1038/s41568-018-0045-0
Cancer is ubiquitous in wildlife and is an increasing concern for endangered species. This Review discusses the impact of cancer on animal species and highlights how studying these effects could reveal shared mechanisms of cancer predisposition between animals and humans.
Full Text | PDF
Collection: Cancer at Nature Research


Amendments & Corrections

Publisher Correction: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance   
John A. Katzenellenbogen, Christopher G. Mayne, Benita S. Katzenellenbogen, Geoffrey L. Greene & Sarat Chandarlapaty

p662 | doi:10.1038/s41568-018-0053-0
Full Text | PDF

Publisher Correction: The molecular landscape of head and neck cancer   
C. René Leemans, Peter J. F. Snijders & Ruud H. Brakenhoff

p662 | doi:10.1038/s41568-018-0057-9
Full Text | PDF

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