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Nature Immunology Contents: October 2018 Volume 19 Issue 10

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Nature Immunology

October 2018 Volume 19, Issue 10

Research Highlights
News & Views
Review Articles
Amendments & Corrections

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Research Highlights


Iron strength    p1039
Ioana Visan

TB prognostic marker    p1039
Ioana Visan

A more human mouse    p1039
Zoltan Fehervari

Bleeding anti-inflammatory    p1039
Zoltan Fehervari

Viral exploitation of mTOR    p1039
Laurie A. Dempsey

Anti-tumor role of metformin    p1039
Laurie A. Dempsey

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News & Views


MicroRNA says no to mass production    pp1040 - 1042
Pengda Chen, Kunyu Liao & Changchun Xiao

Mysterious ILC2 tissue adaptation    pp1042 - 1044
Jinfang Zhu

Humoral immunity goes hormonal    pp1044 - 1046
Joseph Chavarria-Smith, Wouter L. W. Hazenbos & Menno van Lookeren Campagne

It takes a village    pp1046 - 1047
André Veillette & Yan Lu


Review Articles


The identity and function of microglia in neurodegeneration    pp1048 - 1058
Wilbur M. Song & Marco Colonna

Song and Colonna provide an overview of the common microglial response to neurodegeneration and discuss insights from mouse models and the study of human disease-associated genes.




Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia    pp1059 - 1070
Hiroki Kato, Ari Itoh-Nakadai, Mitsuyo Matsumoto, Yusho Ishii, Miki Watanabe-Matsui et al.

Environmental cues instruct cell fate during hematopoiesis. Igarashi and colleagues show that the transcription factors Bach1 and Bach2 promote erythropoiesis and suppress myelopoiesis. Infection and inflammatory signals suppress Bach expression, which results in anemia.


Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis    pp1071 - 1082
Ryota Sato, Akihisa Kato, Takahiko Chimura, Shin-Ichiroh Saitoh, Takuma Shibata et al.

The receptor TLR3 is essential for effective responses to herpes simplex virus type 1. Miyake and colleagues demonstrate that a neuron- and astrocyte-intrinsic pathway of TLR3 and the metabolic checkpoint kinase complex mTORC2 is needed to prevent fulminant infection with this virus and encephalitis.


NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development    pp1083 - 1092
Vedrana Jelenčić, Marko Šestan, Inga Kavazović, Maja Lenartić, Sonja Marinović et al.

Polić and colleagues show that the activating receptor NKG2D specifically sets the activation threshold for the activating receptor NCR1, providing a mechanism distinct from previously known mechanisms of NK cell education.


Tissue signals imprint ILC2 identity with anticipatory function    pp1093 - 1099
Roberto R. Ricardo-Gonzalez, Steven J. Van Dyken, Christoph Schneider, Jinwoo Lee, Jesse C. Nussbaum et al.

Locksley et al. show tissue-specific imprinting dictates the activating receptors ILC2s express, even in germ-free mice. Skin ILC2s are preferentially activated by IL-18, and IL-18 contributes to inflammation in a mouse model of atopic dermatitis.


Sex-hormone-driven innate antibodies protect females and infants against EPEC infection    pp1100 - 1111
Zhutian Zeng, Bas G. J. Surewaard, Connie H. Y. Wong, Christopher Guettler, Bjӧrn Petri et al.

Kubes and colleagues describe the presence in females of estrogen-driven, innate antibodies against specific oligosaccharides in EPEC that are maternally transferrable to offspring in mice and humans.


NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death    pp1112 - 1125
Di Huang, Jianing Chen, Linbin Yang, Qian Ouyang, Jiaqian Li et al.

lncRNAs can regulate immune responses at a number of levels. Song and colleagues demonstrate that the lncRNA NKILA is expressed by tumor-associated cytotoxic T cells, and this predisposes them to activation-induced cell death and escape of tumors from immunologically mediated destruction.


An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells    pp1126 - 1136
Dominik Aschenbrenner, Mathilde Foglierini, David Jarrossay, Dan Hu, Howard L. Weiner et al.

TH17 cells contribute to anti-fungal and anti-bacterial adaptive immune responses. Sallusto and colleagues show that the transcription factor c-Maf has an immunoregulatory role in directing gene expression and tissue residency in human IL-10+ TH17 cell subsets.




The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types    pp1137 - 1145
Jing-Ping Hsin, Yuheng Lu, Gabriel B. Loeb, Christina S. Leslie & Alexander Y. Rudensky

MicroRNAs regulate gene expression by targeting mRNAs via complementarity with seed sequences. Rudensky and colleagues provide genome-wide profiles of the microRNA miR-155 in multiple immune cell lineages and identify its cell-type effects on gene expression.


Amendments & Corrections


Author Correction: The twilight of immunity: emerging concepts in aging of the immune system    p1146
Janko Nikolich-Žugich

Publisher Correction: Gene regulation: c-Maf in CD4+ T cells: it’s all about context    p1146
W. Nicholas Haining & Sarah A. Weiss

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