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donderdag 27 september 2018

Nature Cell Biology contents: October 2018 Volume 20 Number 10

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October 2018 Volume 20, Issue 10

News & Views
Review Articles
Technical Reports
Amendments & Corrections
Nature Index 2018 Rising Stars 

Creative minds drive the scientific enterprise. This supplement profiles up-and-coming researchers in the natural sciences who have achieved excellence in the Nature Index, and have demonstrated the passion, ambition and resilience to rise even higher in the competitive world of academia. 

Read the full supplement 



Taking a peek into the editor’s office    p1101

News & Views


Microenvironmental cues in cancer stemness    pp1102 - 1104
D. J. Flanagan, M. C. Hodder & O. J. Sansom

Metabolic control of ferroptosis in cancer    pp1104 - 1105
Michael P. Murphy

Long noncoding RNAs in gut stem cells    pp1106 - 1107
Pantelis Hatzis & Hugo J. G. Snippert

A mitochondria–paraspeckle crosstalk    pp1108 - 1109
Archa H. Fox

Nature Cell Biology
Cold Spring Harbor Asia Conference on Single Cell
Suzhou, China
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Review Articles


Life, death and autophagy    pp1110 - 1117
Johnna Doherty & Eric H. Baehrecke

In this Review, Doherty and Baehrecke discuss the multiple roles of autophagy during cell survival and cell death. They cover the interplay between autophagy, apoptosis and necrosis, as well as engulfment and inflammation.




Single particle trajectories reveal active endoplasmic reticulum luminal flow    pp1118 - 1125
David Holcman, Pierre Parutto, Joseph E. Chambers, Marcus Fantham, Laurence J. Young et al.

Using super-resolution microscopy, tracking of single particle trajectories of endoplasmic reticulum (ER) luminal proteins traversing tubular ER, and measuring ER dynamics, Holcman et al. show that ER content is propelled by active luminal flow.


Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis    pp1126 - 1133
Amrita Singh, Tanumoy Saha, Isabell Begemann, Andrea Ricker, Harald Nüsse et al.

Studying early Drosophila wing epithelium development, Singh et al. find that individual cells are mechanically autonomous, and that their elongation along the proximal–distal axis is driven by polarized microtubule-mediated pushing forces.




LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis    pp1134 - 1144
Pingping Zhu, Jiayi Wu, Yanying Wang, Xiaoxiao Zhu, Tiankun Lu et al.

Zhu et al. show that the long noncoding RNA lncGata6 enhances Wnt signalling in intestinal stem cells by recruiting the NURF remodelling complex onto the Ehf promoter and initiating its transcription, which triggers expression of Lgr4/5.


Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria    pp1145 - 1158
Yang Wang, Shi-Bin Hu, Meng-Ran Wang, Run-Wen Yao, Di Wu et al.

Wang et al. show that mitochondrial stress alters paraspeckle number and morphology through regulating the transcription and processing of lncRNA NEAT1, retaining mRNAs of mitochondrial proteins in paraspeckles.


Fam49/CYRI interacts with Rac1 and locally suppresses protrusions    pp1159 - 1171
Loic Fort, José Miguel Batista, Peter A. Thomason, Heather J. Spence, Jamie A. Whitelaw et al.

Fort et al. identify CYRI as a conserved negative modulator of Scar–WAVE-induced lamellipodia by interacting directly with active Rac1, thereby conferring pseudopod plasticity and dynamics during motility.


Direct induction of microtubule branching by microtubule nucleation factor SSNA1    pp1172 - 1180
Nirakar Basnet, Hana Nedozralova, Alvaro H. Crevenna, Satish Bodakuntla, Thomas Schlichthaerle et al.

Basnet et al. discover that in vitro SSNA1 forms fibrils that attach along protofilaments and guide these to grow away from microtubules, forming templates for branched microtubules. SSNA1 mutations that perturb this process lead to defective axon branching in primary neurons.


BAP1 links metabolic regulation of ferroptosis to tumour suppression    pp1181 - 1192
Yilei Zhang, Jiejun Shi, Xiaoguang Liu, Li Feng, Zihua Gong et al.

Zhang et al. show that BAP1 suppresses SLC7A11 expression and cystine uptake, thereby promoting ferroptosis and inhibiting tumour growth.


Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer    pp1193 - 1202
Kristiaan J. Lenos, Daniël M. Miedema, Sophie C. Lodestijn, Lisanne E. Nijman, Tom van den Bosch et al.

Lenos et al. report that the spatiotemporal regulation of stem cell functionality is not intrinsically determined but environmentally defined during tumour growth and drug response in colon cancer.


A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma    pp1203 - 1214
J. Matthew Barnes, Shelly Kaushik, Russell O. Bainer, Jason K. Sa, Elliot C. Woods et al.

Barnes et al. report a dynamic and reciprocal crosstalk between tissue tension and glycocalyx bulkiness that promotes a mesenchymal, stem-like phenotype in GBM.


Technical Reports


Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities    pp1215 - 1225
Sohum Mehta, Yong Zhang, Richard H. Roth, Jin-fan Zhang, Albert Mo et al.

Mehta et al. create single-fluorophore kinase activity sensors for PKA, PKC and ERK in different colours, and demonstrate that they enable multiplex imaging of a combination of signalling activities in cell lines and primary rat neurons.


Amendments & Corrections


Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation    p1226
Yuhui Jiang, Xu Qian, Jianfeng Shen, Yugang Wang, Xinjian Li et al.

Publisher Correction: NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming    p1227
Qiang Zhuang, Wenjuan Li, Christina Benda, Zhijian Huang, Tanveer Ahmed et al.

Publisher Correction: Single-cell multi-omics sequencing of human early embryos    p1227
Lin Li, Fan Guo, Yun Gao, Yixin Ren, Peng Yuan et al.

Publisher Correction: Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing    p1227
Shuai Gao, Liying Yan, Rui Wang, Jingyun Li, Jun Yong et al.

Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours    p1228
Javier Garcia-Bermudez, Lou Baudrier, Konnor La, Xiphias Ge Zhu, Justine Fidelin et al.

Publisher Correction: AMP kinase promotes glioblastoma bioenergetics and tumour growth    p1228
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang et al.

Publisher Correction: IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A    p1228
Hery Urra, Daniel R. Henriquez, José Cánovas, David Villarroel-Campos, Amado Carreras-Sureda et al.

Publisher Correction: Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures    p1229
Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na et al.

Publisher Correction: FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis    p1229
Laura Chan Wah Hak, Shaheen Khan, Ilaria Di Meglio, Ah-Lai Law, Safa Lucken-Ardjomande Häsler et al.

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