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woensdag 1 augustus 2018

Nature Reviews Urology - Table of Contents alert Volume 15 Issue 8

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Nature Reviews Urology


August 2018 Volume 15, Issue 8

Research Highlights
News & Views
Consensus Statement

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Towards gender diversity in urological leadership    pp463 - 464
Jiasian Teh, Tatenda C. Nzenza, Stephanie op't Hoog & Nathan Lawrentschuk

Research Highlights

Checkpoint inhibitor combination sets the wheels IMmotion    p465
Conor A. Bradley

Gemcitabine reduces recurrence    p466
Louise Stone

Signal of GV1001 efficacy    pp466 - 467
Clemens Thoma

TRPV4 targeting improves function in DUA rat model    pp466 - 467
Annette Fenner

Diagnostic microfluidic immunoassays — go with the flow    p467
Conor A. Bradley

Louise Stone

[177Lu]PSMA-617 radionuclide therapy shows promise    p468
Conor A. Bradley

Nature Reviews Urology
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News & Views

What are bacteria doing in the bladder?    pp469 - 470
Gregor Reid

Optimizing radiotherapy for intermediate-risk localized disease    pp470 - 471
Pirus Ghadjar & Thomas Wiegel

Underfunded and fragmented — a storm is brewing for sexual and reproductive health services    pp472 - 473
Neha Pathak & Shema Tariq


Historical and contemporary perspectives on cribriform morphology in prostate cancer    pp475 - 482
Matthew Truong, Thomas Frye, Edward Messing & Hiroshi Miyamoto

In this article, the authors discuss cribriform morphology – now recognized as the most aggressive Gleason pattern 4 subtype – and suggest that prostate cancer grading paradigms should be further refined to distinguish cribriform from noncribriform Gleason pattern 4.

Personalization of prostate cancer therapy through phosphoproteomics    pp483 - 497
Wei Yang, Michael R. Freeman & Natasha Kyprianou

Yang and colleagues discuss the clinical need and rationale for a phosphoproteomics approach to personalizing prostate cancer treatment. They describe current technologies, clinical findings, and challenges and strategies to realizing routine clinical application of phosphoproteomics.

Systemic treatments for high-risk localized prostate cancer    pp498 - 510
Géraldine Pignot, Denis Maillet, Emmanuel Gross, Philippe Barthelemy, Jean-Baptiste Beauval et al.

Patients with high-risk localized prostate cancer have a poor prognosis, and appropriate treatments are therefore imperative. Herein, the authors present the current clinical evidence of the benefit of neoadjuvant and adjuvant systemic therapies for the treatment of these patients.

Consensus Statement

An interdisciplinary consensus on the management of bone metastases from renal cell carcinoma    pp511 - 521
Viktor Grünwald, Berit Eberhardt, Axel Bex, Anne Flörcken, Thomas Gauler et al.

In this Expert Consensus, Grünwald et al. summarize their recommendations for the diagnosis and treatment of patients with renal cell carcinoma and metastasis to the bone. They also outline current challenges and unmet patient needs that should be addressed in the future.

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