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dinsdag 7 augustus 2018

Nature Medicine Contents: August 2018 Volume 24 Number 8 pp 1081-1292

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Focus on Autoimmune Disease from Nature Immunology

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TABLE OF CONTENTS

August 2018 Volume 24, Issue 8

Editorial
News Feature
Research Highlights
News & Views
Perspectives
Brief Communications
Letters
Articles
Resources
Amendments & Corrections
 
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Nature Conference on Inflammation and Cancer

This meeting will bring together a diverse group of researchers from the many interconnected areas of immunology and cancer to discuss how inflammation affects tumour development and metastasis. Presentations will focus on the most recent findings on the tumour-promoting and -suppressing effects of inflammation, the immune tumour environment, and therapeutic approaches.

October 23-25, 2018 | Beijing, China 

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2018 longlist - see the full line up 

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Nature Research Custom presents a webcast on: Molecular imaging reveals ONC201 antitumor efficacy and immune stimulation in cancer models

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Editorial

 

Keep off-target effects in focus    p1081
doi:10.1038/s41591-018-0150-3

News Feature

 

Discovery cycle    pp1082 - 1085
Shraddha Chakradhar
doi:10.1038/s41591-018-0149-9

Pondering privatization    pp1086 - 1087
Katharine Gammon
doi:10.1038/s41591-018-0148-x

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Research Highlights

 

Identifying atrial fibrillation    p1088
Hannah Stower
doi:10.1038/s41591-018-0151-2

An antiviral for smallpox    p1088
Hannah Stower
doi:10.1038/s41591-018-0152-1

A wasted early warning    p1088
Hannah Stower
doi:10.1038/s41591-018-0153-0

Predicting preterm birth    p1088
Hannah Stower
doi:10.1038/s41591-018-0154-z

Cell therapy for spinal cord injury    p1088
Hannah Stower
doi:10.1038/s41591-018-0155-y

Medicine
JOBS of the week
Postdoctoral Scholar
The University of Iowa
Postdoctoral Research Scientist
Columbia University
Postdoctoral Research Associate - PRA-Immunology
National Jewish Health
Associate Senior Lecturer (Assistant Professor) in molecular medicine - tenure track
University of Gothenburg (GU)
Post-doctoral Associate
University of Louisville Health Science Center, School of Medicine
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Medicine
EVENT
Big Data and Cancer Precision Medicine
01.10.18
Boston, USA
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Scientific Reports Editor's choice collection: Machine Learning in Healthcare There is great scope for machine intelligence to bolster human endeavours to improve health and wellbeing. Here is just a small selection of research published in Scientific Reports that has contributed to the rapid progress of this field in the past few years. Access the collection >>>
 

News & Views

 

Beta cell preservation in patients with type 1 diabetes    pp1089 - 1090
Tony K. T. Lam & David Z. I. Cherney
doi:10.1038/s41591-018-0144-1

The calcium channel blocker verapamil preserves beta cells in a clinical trial of individuals with adult-onset type I diabetes.

 

Cellular origin of human cardiac macrophage populations    pp1091 - 1092
Freya R. Svedberg & Martin Guilliams
doi:10.1038/s41591-018-0143-2

Targeting senescence    pp1092 - 1094
Manuel Serrano & Nir Barzilai
doi:10.1038/s41591-018-0141-4

Immunotherapy for glioblastoma: going viral    pp1094 - 1096
J. Bryan Iorgulescu, David A. Reardon, E. Antonio Chiocca & Catherine J. Wu
doi:10.1038/s41591-018-0142-3

Intratumoral infusion of a nonpathogenic replication-competent recombinant polio-rhinovirus chimera (PVSRIPO) for recurrent glioblastoma demonstrates safety and promising preliminary treatment responses.

 

Perspectives

 

Learning from bacterial competition in the host to develop antimicrobials    pp1097 - 1103
Manuela Raffatellu
doi:10.1038/s41591-018-0145-0

The delicate balance of microbial communities is maintained by competitive mechanisms that provide an avenue for new antimicrobial development.

 

Brief Communications

 

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates    pp1104 - 1107
Dawn M. Dudley, Koen K. Van Rompay, Lark L. Coffey, Amir Ardeshir, Rebekah I. Keesler et al.
doi:10.1038/s41591-018-0088-5

Zika virus infection during pregnancy is associated with an increased rate of fetal loss in nonhuman primates, as reported in this multicenter analysis.

 

Letters

 

Verapamil and beta cell function in adults with recent-onset type 1 diabetes    pp1108 - 1112
Fernando Ovalle, Tiffany Grimes, Guanlan Xu, Anish J. Patel, Truman B. Grayson et al.
doi:10.1038/s41591-018-0089-4

A phase 2 placebo-controlled randomized trial reveals that verapamil promotes beta cell function in adult subjects with recent-onset type 1 diabetes.

 

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health    pp1113 - 1120
Ludivine Laurans, Nicolas Venteclef, Yacine Haddad, Mouna Chajadine, Fawaz Alzaid et al.
doi:10.1038/s41591-018-0060-4

Indoleamine 2,3-dioxygenase normally suppresses inflammation, but knockout of its gene is metabolically beneficial as its depletion reshapes the gut microbiota.

 

Metformin reverses established lung fibrosis in a bleomycin model    pp1121 - 1131
Sunad Rangarajan, Nathaniel B. Bone, Anna A. Zmijewska, Shaoning Jiang, Dae Won Park et al.
doi:10.1038/s41591-018-0087-6

Metformin reverses established lung fibrosis in a bleomycin model in mice.

 

Reducing protein oxidation reverses lung fibrosis    pp1128 - 1135
Vikas Anathy, Karolyn G. Lahue, David G. Chapman, Shi B. Chia, Dylan T. Casey et al.
doi:10.1038/s41591-018-0090-y

Targeting a post-translational modification of Fas by recombinant Glrx reverses established lung fibrosis in a mouse model of age-related idiopathic pulmonary fibrosis.

 

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis    pp1136 - 1142
Yong-Jie Zhang, Tania F. Gendron, Mark T. W. Ebbert, Aliesha D. O’Raw, Mei Yue et al.
doi:10.1038/s41591-018-0071-1

ALS/FTD-related C9orf72 dipeptide-repeat proteins inhibit protein translation and impair stress granule dynamics, and they cause motor and cognitive deficits in mice.

 

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses    pp1143 - 1150
Israel Cañadas, Rohit Thummalapalli, Jong Wook Kim, Shunsuke Kitajima, Russell William Jenkins et al.
doi:10.1038/s41591-018-0116-5

Retroelements located in antisense orientation within interferon-regulated genes are reactivated in a subset of cancer cells and initiate a STING- and MAVS-dependent feed-forward inflammatory loop, driving antitumor immunity and exhaustion.

 

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia    pp1151 - 1156
Darren C. Johnson, Cornelius Y. Taabazuing, Marian C. Okondo, Ashley J. Chui, Sahana D. Rao et al.
doi:10.1038/s41591-018-0082-y

Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 block AML progression by promoting CARD8-dependent pyroptosis of leukemic myeloid cells.

 

Articles

 

Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia    pp1157 - 1166
Nikos Kourtis, Charalampos Lazaris, Kathryn Hockemeyer, Juan Carlos Balandrán, Alejandra R. Jimenez et al.
doi:10.1038/s41591-018-0105-8

Oncogenic NOTCH1 controls transcriptional activation of the heat shock response in T cell acute lymphoblastic leukemia and uncovers potential biomarkers of sensitivity to HSP90 inhibition.

 

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib    pp1167 - 1177
Lynn Quek, Muriel D. David, Alison Kennedy, Marlen Metzner, Michael Amatangelo et al.
doi:10.1038/s41591-018-0115-6

Mapping of the clonal structure of bone marrow cells in patients with acute myeloid leukemia treated with the IDH2 inhibitor enasidenib reveals heterogeneity in the cellular differentiation response and in mechanisms of relapse.

 

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments    pp1178 - 1191
Kevin C. Barry, Joy Hsu, Miranda L. Broz, Francisco J. Cueto, Mikhail Binnewies et al.
doi:10.1038/s41591-018-0085-8

Cross-talk between innate immune cells helps to enhance the antitumor T cell response during checkpoint blockade therapy.

 

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate    pp1192 - 1203
Lukas Bunse, Stefan Pusch, Theresa Bunse, Felix Sahm, Khwab Sanghvi et al.
doi:10.1038/s41591-018-0095-6

An oncometabolite produced by tumor cells acts as a paracrine immunosuppressant dampening antitumor T cell responses in glioma.

 

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells    pp1204 - 1215
Mara Vinci, Anna Burford, Valeria Molinari, Ketty Kessler, Sergey Popov et al.
doi:10.1038/s41591-018-0086-7

Genomic and functional analysis of intratumor heterogeneity in pediatric glioma uncovers early clonal divergence and stable spontaneous cooperation between subclonal populations throughout tumor evolution.

 

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells    pp1216 - 1224
Christopher A. Vakulskas, Daniel P. Dever, Garrett R. Rettig, Rolf Turk, Ashley M. Jacobi et al.
doi:10.1038/s41591-018-0137-0

A bacterial screen yields a Cas9 variant that retains high on-target activity when delivered in the RNP format. As proof of principle, this Cas9 variant enables high-level correction of the sickle cell disease mutation in patient-derived HSPCs.

 

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure    pp1225 - 1233
Christina Yingxian Chen, Matthew A. Caporizzo, Kenneth Bedi, Alexia Vite, Alexey I. Bogush et al.
doi:10.1038/s41591-018-0046-2

Post-translational modification of microtubules by detyrosination is prevalent in failing human cardiomyocytes and inhibits cardiomyocyte contraction, suggesting a new therapeutic strategy for improving heart function.

 

The human heart contains distinct macrophage subsets with divergent origins and functions    pp1234 - 1245
Geetika Bajpai, Caralin Schneider, Nicole Wong, Andrea Bredemeyer, Maarten Hulsmans et al.
doi:10.1038/s41591-018-0059-x

Study of macrophage heterogeneity in human hearts reveals a subset of inflammatory macrophages that is associated with cardiac dysfunction in patients with heart failure.

 

Senolytics improve physical function and increase lifespan in old age    pp1246 - 1256
Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, Bettina M. Weigand, Allyson K. Palmer et al.
doi:10.1038/s41591-018-0092-9

Transfer of senescent cells into naive, young mice can induce physical dysfunction, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.

 

Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke    pp1257 - 1267
Dhakshin S. Ramanathan, Ling Guo, Tanuj Gulati, Gray Davidson, April K. Hishinuma et al.
doi:10.1038/s41591-018-0058-y

Recovery of skilled motor function in rodents after stroke correlates with the restoration of low-frequency quasi-oscillatory activity in the motor cortex, and neuromodulatory electrical stimulation targeting this activity can further accelerate recovery.

 

Anatomical and functional dichotomy of ocular itch and pain    pp1268 - 1276
Cheng-Chiu Huang, Weishan Yang, Changxiong Guo, Haowu Jiang, Fengxian Li et al.
doi:10.1038/s41591-018-0083-x

A molecularly defined set of sensory fibers expressing MrgprA3 mediate ocular itch via specific anatomical projections to the conjunctiva, which can be targeted therapeutically in rodent models.

 

Resources

 

Phenotype molding of stromal cells in the lung tumor microenvironment    pp1277 - 1289
Diether Lambrechts, Els Wauters, Bram Boeckx, Sara Aibar, David Nittner et al.
doi:10.1038/s41591-018-0096-5

A comprehensive single-cell analysis of the lung cancer microenvironment reveals marked heterogeneity of transcriptional networks that defines novel clinically relevant stromal cell populations.

 

Amendments & Corrections

 

Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes    pp1290 - 1291
Bjoern Chapuy, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov et al.
doi:10.1038/s41591-018-0097-4

Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes    p1292
Bjoern Chapuy, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov et al.
doi:10.1038/s41591-018-0098-3

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