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vrijdag 27 juli 2018

Nature Reviews Neurology - Table of Contents alert Volume 14 Issue 8

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Nature Reviews Neurology

Focus on Autoimmune Disease from Nature Immunology 

A series of Reviews specially commissioned by Nature Immunology discuss the genetic, environmental, microbial and cellular factors underpinning autoimmune disease as well as highlight avenues for therapeutic intervention. 

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Produced with support from Janssen Research & Development

August 2018 Volume 14, Issue 8

Research Highlights
News & Views



The struggle for stroke reclassification    pp447 - 448
Raad Shakir

Research Highlights


Retinal nerve fibre layer thickness — a biomarker of early dementia?    p449
Ian Fyfe

The ups and downs of ESOC 2018    p450
Ian Fyfe

APOE4 transforms the transcriptome    pp450 - 451
Charlotte Ridler

Targeting TNF to alleviate Zika virus complications    pp450 - 451
Heather Wood

Exosomes can spread toxic AD pathology    p451
Ian Fyfe

New drug blocks brain metastasis    p452
Charlotte Ridler

Microglia show sex-specific gene expression profiles    p452
Heather Wood

Nature Reviews Neurology
JOBS of the week
Faculty Position, Department of Neuroscience
Mayo Clinic
Excellence in Science PhD Scholarship Award in Neuroscience
UTS - University Of Technology Sydney
Joint Recruitment of Postdoctoral Fellows
Prof. Peter Carmeliet; Prof. Xuri Li
Clinical Professor in Neuroimaging
Cardiff University
Lab Manager Position
Institute of Molecular Biotechnology (IMBA)
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International Colloquium on Neurology & Neurology Surgery
Dubai, UAE
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News & Views


New glioblastoma heterogeneity atlas — a shared resource    pp453 - 454
Wolfgang Wick & Tobias Kessler

Why dystrophin quantification is key in the eteplirsen saga    pp454 - 456
Annemieke Aartsma-Rus & Virginia Arechavala-Gomeza



Sex differences in Alzheimer disease — the gateway to precision medicine    pp457 - 469
Maria Teresa Ferretti, Maria Florencia Iulita, Enrica Cavedo, Patrizia Andrea Chiesa, Annemarie Schumacher Dimech et al.

In this Review, Ferretti et al. discuss the evidence for sex-related differences in Alzheimer disease symptoms, progression, risk factors and treatment, and consider how understanding sex differences is crucial in developing precision medicine.


NREM sleep parasomnias as disorders of sleep-state dissociation    pp470 - 481
Anna Castelnovo, Régis Lopez, Paola Proserpio, Lino Nobili & Yves Dauvilliers

Non-rapid eye movement (NREM) sleep parasomnias are thought to derive from incomplete arousal from NREM sleep. Here, the authors present evidence for coexistence of sleep-like and wake-like brain activity in disorders of arousal, including confusional arousals, sleep terrors and sleepwalking.


Multidimensional communication in the microenvirons of glioblastoma    pp482 - 495
Marike L. Broekman, Sybren L. N. Maas, Erik R. Abels, Thorsten R. Mempel, Anna M. Krichevsky et al.

Glioblastomas remain one of the most aggressive and lethal tumours, with no effective treatments available. Here, Xandra Breakefield and colleagues examine the ways in which glioblastomas manipulate brain cells and immune cells in their environment to support tumour growth and the opportunities available for new therapies that disrupt these interactions.


Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?    pp496 - 506
Gillian Coughlan, Jan Laczó, Jakub Hort, Anne-Marie Minihane & Michael Hornberger

This Review appraises the available evidence for spatial navigation and/or orientation deficits in preclinical, prodromal and confirmed Alzheimer disease with a focus on using spatial navigation as a diagnostic tool. Research gaps and future research priorities are also identified.


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