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Nature Reviews Microbiology contents August 2018 Volume 16 Number 8

Nature Reviews Microbiology

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TABLE OF CONTENTS

August 2018 Volume 16, Issue 8

Research Highlights
News & Analysis
Reviews
 
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Research Highlights

 

Gut microbiota bile acid metabolism controls cancer immunosurveillance    p453
Anna Dart
doi:10.1038/s41579-018-0053-9

The gut microbiota can metabolize bile acids to affect immunosurveillance in the liver of mice and indirectly control the growth of primary liver tumours and liver metastases.

 

ppGpp triggers the switch    p454
Andrea Du Toit
doi:10.1038/s41579-018-0042-z

Breaking barriers    p454
Andrea Du Toit
doi:10.1038/s41579-018-0043-y

Four is a crowd    p454
Andrea Du Toit
doi:10.1038/s41579-018-0044-x

Sharing the burden to build a matrix    pp454 - 455
Ashley York
doi:10.1038/s41579-018-0045-9

This study investigates the benefits of division of labour during extracellular matrix production within biofilms and show that both genetic and phenotypic strategies for a division of labour promote biofilm formation.

 

Falling into your own trap    pp454 - 455
Andrea Du Toit
doi:10.1038/s41579-018-0054-8

Macrophage apoptosis induced by Staphylococcus aureus-generated deoxyadenosine involves a macrophage membrane transporter and kinases of the purine salvage pathway.

 

Oiling the Flavivirus replication machinery    p455
Ashley York
doi:10.1038/s41579-018-0050-z

New drugs underfoot?    p455
Ashley York
doi:10.1038/s41579-018-0051-y

An aquatic origin of retroviruses    p455
Ashley York
doi:10.1038/s41579-018-0052-x

Nature Reviews Microbiology
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News & Analysis

 

Surveying what’s flushed away    p456
Gregorio Iraola & Nitin Kumar
doi:10.1038/s41579-018-0047-7

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Reviews

 

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier    pp457 - 470
Eric C. Martens, Mareike Neumann & Mahesh S. Desai
doi:10.1038/s41579-018-0036-x

The first line of host defence against both encroaching commensal bacteria and invading enteric pathogens is the intestinal mucosal barrier, which is composed of epithelial cells and a host-secreted mucous layer. In this Review, Martens and colleagues discuss the complex interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier.

 

Cyanobacterial blooms    pp471 - 483
Jef Huisman, Geoffrey A. Codd, Hans W. Paerl, Bas W. Ibelings, Jolanda M. H. Verspagen et al.
doi:10.1038/s41579-018-0040-1

Cyanobacteria can form large blooms that threaten the water quality of lakes and seas. In this Review, Huisman and colleagues discuss bloom formation, the impact of eutrophication and climate change, and measures to prevent and control cyanobacterial blooms.

 

Going around in circles: virulence plasmids in enteric pathogens    pp484 - 495
Giulia Pilla & Christoph M. Tang
doi:10.1038/s41579-018-0031-2

Virulence plasmids have a major role in the development of disease that is caused by enteric bacterial pathogens. In this Review, Pilla and Tang discuss virulence plasmids in enteric pathogens, outline the mechanisms by which they are maintained in bacterial populations and speculate on how these might contribute their propagation and success.

 

Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis    pp496 - 507
Sabine Ehrt, Dirk Schnappinger & Kyu Y. Rhee
doi:10.1038/s41579-018-0013-4

As an obligate human pathogen, Mycobacterium tuberculosis has evolved to survive and thrive in biochemically challenging niches in its host. Ehrt, Schnappinger and Rhee review the unique metabolic features that enable M. tuberculosis pathogenesis and persistence but also represent drug targets.

 

Controlling vector-borne diseases by releasing modified mosquitoes    pp508 - 518
Heather A. Flores & Scott L. O’Neill
doi:10.1038/s41579-018-0025-0

Flores and O’Neill review novel approaches to control mosquito-transmitted diseases, with a focus on control methods that are based on the release of mosquitoes, including the release of Wolbachia-infected mosquitoes, and strategies to genetically modify the vector.

 

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