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vrijdag 6 juli 2018

Nature Neuroscience Contents: July 2018 Volume 21 Number 7

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Nature Neuroscience

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July 2018 Volume 21, Issue 7

News & Views
Review Articles
Amendments & Corrections
One of the most important ingredients in breast milk you've never heard of

Nutrition matters, and early diet has life-long effects. So how are indigestible molecules in breast milk helping ensure the healthiest start for both breast-fed and formula-fed babies?

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Produced for Abbott by Nature Research Custom Media 

Content intended for healthcare professionals.


News & Views


The mysterious origins of microglia    pp897 - 899
Florent Ginhoux & Sonia Garel

Modeling Alzheimer’s disease brains in vitro    pp899 - 900
Christopher M. Henstridge & Tara L. Spires-Jones

Stressing the other paraventricular nucleus    pp901 - 902
Kurt M. Fraser & Patricia H. Janak

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Review Articles


Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation    pp903 - 919
Bijan Pesaran, Martin Vinck, Gaute T. Einevoll, Anton Sirota, Pascal Fries et al.

This article presents best practices on how field potential recordings (EEG, MEG, ECoG and LFP) can be analyzed to identify large-scale brain dynamics, and highlights issues and limitations of interpretation.


Nature Spotlight on Hong Kong: Building science innovation 

Hong Kong is maximising major scientific innovation and commercial benefits through its proximity to the research and development hubs in mainland China. Yet barriers to collaboration remain. 

Access the full supplement for more >> 



Optimization of interneuron function by direct coupling of cell migration and axonal targeting    pp920 - 931
Lynette Lim, Janelle M. P. Pakan, Martijn M. Selten, André Marques-Smith, Alfredo Llorca et al.

Circuit assembly relies on several developmental processes that are often considered independently. Lim and colleagues now reveal that cell migration and axon targeting may be mechanistically linked for Martinotti cells during cortical development.


Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program    pp932 - 940
Marisa Karow, J. Gray Camp, Sven Falk, Tobias Gerber, Abhijeet Pataskar et al.

Ascl1 and Sox2 convert human brain pericytes into the two major neuronal subclasses of GABA- and glutamatergic neurons. Unexpectedly, despite the lack of cell division, this conversion requires passage through a neural stem cell-like state.


A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease    pp941 - 951
Joseph Park, Isaac Wetzel, Ian Marriott, Didier Dréau, Carla D’Avanzo et al.

This study describes a 3D human neuron-astrocyte-microglia triculture model of Alzheimer’s disease using a microfluidic platform and recapitulating plaque and tangle pathology, microglial recruitment, neuroinflammation, and cell death.


Dorsal tegmental dopamine neurons gate associative learning of fear    pp952 - 962
Florian Groessl, Thomas Munsch, Susanne Meis, Johannes Griessner, Joanna Kaczanowska et al.

Unpredicted aversive experiences activate DA neurons in dorsal tegmentum; these neurons are important for fear learning. This prediction-error circuit module linking amygdala and dorsal tegmentum enables a solution to an associative learning problem.


The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism    pp963 - 973
B. Sofia Beas, Brandon J. Wright, Miguel Skirzewski, Yan Leng, Jung Ho Hyun et al.

Beas et al. show that stress exposure drives disinhibition of PVT projection neurons. This process involves an LC-mediated rise in extracellular DA in the midline thalamus, requires D2 receptors on PVT neurons, and increases stress sensitivity.


Thalamic dual control of sleep and wakefulness    pp974 - 984
Thomas C. Gent, Mojtaba Bandarabadi, Carolina Gutierrez Herrera & Antoine R. Adamantidis

This study shows that tonic firing of centromedial thalamic neurons triggers rapid arousal, whereas burst firing triggers brain-wide propagating cortical slow waves and promotes sleep recovery, indicative of a midline thalamus sleep–wake hub.


A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus    pp985 - 995
David L. Hunt, Daniele Linaro, Bailu Si, Sandro Romani & Nelson Spruston

The authors identify a CA3 new pyramidal cell type with unique morphofunctional characteristics and distinct synaptic inputs and describe how these cells contribute to sharp-wave synchronization events, which are vital to hippocampal memory function.


Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene    pp996 - 1003
Steven J. Middleton, Emily M. Kneller, Shuo Chen, Ikuo Ogiwara, Mauricio Montal et al.

Middleton et al. demonstrate that heterozygous deletion of the frequently mutated Scn2a gene leads to reduced performance in spatial memory tasks in mice, resulting from incomplete sequence reactivation during hippocampal sharp wave ripples.




Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts    pp1004 - 1014
Daria Merkurjev, Wan-Ting Hong, Kei Iida, Ikumi Oomoto, Belinda J. Goldie et al.

A localized set of mRNA at the synapse facilitates synapse formation and plasticity. The authors show an enrichment of N6-methyladenosine (m6A) modifications of these mRNA at the synapse and link m6A recognition by molecular readers to synaptic function.


Amendments & Corrections


Author Correction: Dorsal hippocampus contributes to model-based planning    p1015
Kevin J. Miller, Matthew M. Botvinick & Carlos D. Brody

Author Correction: Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease    p1015
Subhojit Roy

Author Correction: Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation    p1015
Sebastian Preissl, Rongxin Fang, Hui Huang, Yuan Zhao, Ramya Raviram et al.

Author Correction: Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice    p1016
Catherine J. Stoodley, Anila M. D’Mello, Jacob Ellegood, Vikram Jakkamsetti, Pei Liu et al.

Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain    p1016
Jennifer A Erwin, Apuã C M Paquola, Tatjana Singer, Iryna Gallina, Mark Novotny et al.

Author Correction: Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals    p1016
Craig Blomeley, Celia Garau & Denis Burdakov

Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium    p1017
Stephan J. Sanders, Benjamin M. Neale, Hailiang Huang, Donna M. Werling, Joon-Yong An et al.

Publisher Correction: Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex    p1017
Sinisa Hrvatin, Daniel R. Hochbaum, M. Aurel Nagy, Marcelo Cicconet, Keiramarie Robertson et al.

Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease    p1018
Raffaella Nativio, Greg Donahue, Amit Berson, Yemin Lan, Alexandre Amlie-Wolf et al.

Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry    p1018
Sandra Sanchez-Roige, Pierre Fontanillas, Sarah L. Elson, Anita Pandit, Ellen M. Schmidt et al.

Publisher Correction: Viewpoints: how the hippocampus contributes to memory, navigation and cognition    p1018
John Lisman, György Buzsáki, Howard Eichenbaum, Lynn Nadel, Charan Ranganath et al.

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