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dinsdag 10 juli 2018

Nature Medicine Contents: June 2018 Volume 24 Number 7 pp 881-1080

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TABLE OF CONTENTS

July 2018 Volume 24, Issue 7

Editorial
News Feature
Correspondence
Q&A
Research Highlights
News & Views
Review Articles
Brief Communications
Letters
Articles
 
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Editorial

 

Actionable equality    p881
doi:10.1038/s41591-018-0118-3

News Feature

 

Matching up    pp882 - 884
Shraddha Chakradhar
doi:10.1038/s41591-018-0113-8

Homeward bound    pp885 - 889
Shraddha Chakradhar
doi:10.1038/s41591-018-0112-9

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Animation on CRISPR: Gene editing and beyond

The CRISPR-Cas9 system has revolutionised gene editing, but cutting DNA isn't all it can do.

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Produced with support from: 
Dharmacon 
 

Correspondence

 

F508del-CFTR is not corrected by thymosin α1    pp890 - 891
Elizabeth Matthes, John W. Hanrahan & André M. Cantin
doi:10.1038/s41591-018-0079-6

Reply to ‘F508del-CFTR is not corrected by thymosin α1’    pp891 - 893
Luigina Romani, Claudia Stincardini, Stefano Giovagnoli, Maurizio Paci, Valeria R. Villella et al.
doi:10.1038/s41591-018-0080-0

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Nature Outlook: The future of medicine 

Modern medicine is affording people longer and healthier lives. But researchers want to take improvements in health even further. With advances in gene editing, technology to overcome paralysis and efforts to address high drug costs, the future of medicine is bright. 

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Produced with support from Merck KGaA, Darmstadt, Germany 
 

Q&A

 

Searching for Alzheimer’s disease therapies    pp894 - 897
Hannah Stower
doi:10.1038/s41591-018-0127-2

Research Highlights

 

A pig model of Huntington’s disease    p898
Hannah Stower
doi:10.1038/s41591-018-0119-2

Detecting dengue    p898
Hannah Stower
doi:10.1038/s41591-018-0120-9

Understanding genetic disease with electronic medical records    p898
Hannah Stower
doi:10.1038/s41591-018-0121-8

Green light for data sharing    p898
Hannah Stower
doi:10.1038/s41591-018-0122-7

Predicting colon cancer recurrence    p898
Hannah Stower
doi:10.1038/s41591-018-0123-6

Medicine
JOBS of the week
Postdoctoral research fellowship in Chemical Neuroscience
University of Oslo
Postdoctoral Fellow Position
Vanderbilt University Medical Center
Postdoctoral Research Fellow
Hospital for Special Surgery and Weill Cornell Medical College
Postdoctoral Research Associate
Texas A&M Institute of Biosciences and Technology
Postdoctoral Fellow- Immunology
NYU Langone Health
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Cardiovascular, Allergy, and Respiratory Summit (CARPS)
07.11.18
San Diego, USA
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News & Views

 

A path to efficient gene editing    pp899 - 900
Fyodor D. Urnov
doi:10.1038/s41591-018-0110-y

Fire prevention in the Parkinson’s disease brain    pp900 - 902
Lena Brundin, Liza Bergkvist & Patrik Brundin
doi:10.1038/s41591-018-0109-4

A treatment strategy for KRAS-driven tumors    pp902 - 904
Trang T. Mai & Piro Lito
doi:10.1038/s41591-018-0111-x

Predicting progression to AML    pp904 - 906
Rob S. Sellar, Siddhartha Jaiswal & Benjamin L. Ebert
doi:10.1038/s41591-018-0114-7

Microbiome metabolomics reveals new drivers of human liver steatosis    pp906 - 907
Nathalie M. Delzenne & Laure B. Bindels
doi:10.1038/s41591-018-0126-3

Review Articles

 

Mechanisms of NAFLD development and therapeutic strategies    pp908 - 922
Scott L. Friedman, Brent A. Neuschwander-Tetri, Mary Rinella & Arun J. Sanyal
doi:10.1038/s41591-018-0104-9

Understanding of pathogenic mechanisms and clinical features of NAFLD is driving progress in therapeutic strategies now in clinical trials.

 

Brief Communications

 

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection    pp923 - 926
Donn J. Colby, Lydie Trautmann, Suteeraporn Pinyakorn, Louise Leyre, Amélie Pagliuzza et al.
doi:10.1038/s41591-018-0026-6

Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.

 

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response    pp927 - 930

doi:10.1038/s41591-018-0049-z

CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in immortalized human retinal pigment epithelial cells.

 

Letters

 

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease    pp931 - 938
Seung Pil Yun, Tae-In Kam, Nikhil Panicker, SangMin Kim, Yumin Oh et al.
doi:10.1038/s41591-018-0051-5

Agonism of microglial glucagon-like peptide-1 receptor (GLP1R) using a brain-penetrant peptide prevents the generation of neurotoxic astrocytes and ameliorates disease progression in two rodent models of Parkinson’s disease.

 

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells    pp939 - 946
Robert J. Ihry, Kathleen A. Worringer, Max R. Salick, Elizabeth Frias, Daniel Ho et al.
doi:10.1038/s41591-018-0050-6

CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in human pluripotent cells.

 

DNA repair processes are critical mediators of p53-dependent tumor suppression    pp947 - 953
Ana Janic, Liz J. Valente, Matthew J. Wakefield, Leon Di Stefano, Liz Milla et al.
doi:10.1038/s41591-018-0043-5

In vivo shRNA screens in sensitized genetic backgrounds identify p53-activated target genes involved in DNA repair that enable its tumor suppressor function.

 

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase    pp954 - 960
Dietrich A. Ruess, Guus J. Heynen, Katrin J. Ciecielski, Jiaoyu Ai, Alexandra Berninger et al.
doi:10.1038/s41591-018-0024-8

The phosphatase SHP2 is required for mutant KRAS signaling in pancreatic and non-small-cell lung cancers and drives resistance to MEK inhibition.

 

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo    pp961 - 967
Sara Mainardi, Antonio Mulero-Sánchez, Anirudh Prahallad, Giovanni Germano, Astrid Bosma et al.
doi:10.1038/s41591-018-0023-9

Combined inhibition of SHP2 and MEK is an effective therapeutic approach in non-small-cell lung cancer.

 

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition    pp968 - 977
Gabrielle S. Wong, Jin Zhou, Jie Bin Liu, Zhong Wu, Xinsen Xu et al.
doi:10.1038/s41591-018-0022-x

Amplification of wild-type KRAS in a subset of gastroesophageal tumors drives intrinsic resistance to MAPK inhibition that can be overcome by combined targeting of MEK and SHP2.

 

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing    pp978 - 985
Xinyi Guo, Yuanyuan Zhang, Liangtao Zheng, Chunhong Zheng, Jintao Song et al.
doi:10.1038/s41591-018-0045-3

Deep single-cell RNA sequencing of tumor-infiltrating T cells in non-small-cell lung cancer identifies features associated with functional states and clinical outcome

 

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis    pp986 - 993
Peter Savas, Balaji Virassamy, Chengzhong Ye, Agus Salim, Christopher P. Mintoff et al.
doi:10.1038/s41591-018-0078-7

Extensive, high-dimensional characterization of T cells in breast cancer reveals activated TRM population and a gene signature associated with improved prognosis.

 

Articles

 

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade    pp994 - 1004
Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, Andreas Roller, Marcel Trefny et al.
doi:10.1038/s41591-018-0057-z

Tumor-infiltrating CD8+ T cells with high expression of PD-1 in non-small-cell lung cancer are distinct from exhausted T cells in chronic virus infection, have high tumor reactivity and associate with response to PD-1-targeted immunotherapy.

 

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism    pp1005 - 1014
Eleonora Trotta, Paul H. Bessette, Stephanie L. Silveria, Lauren K. Ely, Kevin M. Jude et al.
doi:10.1038/s41591-018-0070-2

A human anti-IL-2 antibody that selectively expands regulatory T cells is developed in this study for clinical applications aiming to mitigate autoimmune and inflammatory disorders and to promote transplant tolerance.

 

Somatic mutations precede acute myeloid leukemia years before diagnosis    pp1015 - 1023
Pinkal Desai, Nuria Mencia-Trinchant, Oleksandr Savenkov, Michael S. Simon, Gloria Cheang et al.
doi:10.1038/s41591-018-0081-z

Somatic mutations detected years before diagnosis increase the odds of development of acute myeloid leukemia in women.

 

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis    pp1024 - 1035
Neibla Priego, Lucía Zhu, Cátia Monteiro, Manon Mulders, David Wasilewski et al.
doi:10.1038/s41591-018-0044-4

Reactive astrocytes expressing STAT3 support the metastatic growth of tumor cells colonizing the brain and can be pharmacologically targeted to improve the clinical management of patients with secondary brain tumors.

 

An inhibitor of oxidative phosphorylation exploits cancer vulnerability    pp1036 - 1046
Jennifer R. Molina, Yuting Sun, Marina Protopopova, Sonal Gera, Madhavi Bandi et al.
doi:10.1038/s41591-018-0052-4

A new inhibitor targeting the mitochondrial complex I shows antitumor activity in preclinical models of acute myeloid leukemia and glioblastoma relying on oxidative phosphorylation.

 

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer    pp1047 - 1057
Yonathan Lissanu Deribe, Yuting Sun, Christopher Terranova, Fatima Khan, Juan Martinez-Ledesma et al.
doi:10.1038/s41591-018-0019-5

SMARCA4 loss in non-small-cell lung cancer creates a metabolic dependency on oxidative phosphorylation that can be targeted using a new small-molecule inhibitor.

 

Inactivating hepatic follistatin alleviates hyperglycemia    pp1058 - 1069
Rongya Tao, Caixia Wang, Oliver Stöhr, Wei Qiu, Yue Hu et al.
doi:10.1038/s41591-018-0048-0

Follistatin acts as a hepatokine to induce insulin resistance and can be targeted to improve diabetes in mice.

 

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women    pp1070 - 1080
Lesley Hoyles, José-Manuel Fernández-Real, Massimo Federici, Matteo Serino, James Abbott et al.
doi:10.1038/s41591-018-0061-3

Metabolic activity of specific human gut microorganisms contributes to liver steatosis in obese women.

 

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