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dinsdag 10 juli 2018

Nature Biotechnology Contents: Volume 36 pp 555 - 666

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Nature Biotechnology

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TABLE OF CONTENTS

July 2018 Volume 36, Issue 7

Editorial
News
Correspondence
Feature
News and Views
Research
Careers and Recruitment
Corrigenda
Errata
 
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Elucidate complex cellular pathways within 2D and 3D cellular structures in response to chemical stimulation.

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BIOPHARMA DEALMAKERSCompany Profiles and Partnering Opportunities

 

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KACST Impact

KACST Impact is a new online publication highlighting the latest cutting edge scientific research conducted at King Abdulaziz City for Science and Technology (KACST) that features various stories ranging from exciting new scientific finds to the commercialization of innovative discoveries. 

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Editorial

 

Wanted: a reward for antibiotic development    p555
doi:10.1038/nbt.4193

News

 

Drug designers embrace cryo-EM    pp557 - 558
Michael Eisenstein
doi:10.1038/nbt0718-557

Golden Rice is safe to eat, says FDA    pp559 - 560
Brian Owens
doi:10.1038/nbt0718-559a

First migraine-prevention antibody approved    p559
doi:10.1038/nbt0718-559b

New money flows to CARB-X for antimicrobials    p560
doi:10.1038/nbt0718-560

Clinical trials go virtual, big pharma dives in    pp561 - 562
Eric Smalley
doi:10.1038/nbt0718-561

CRISPR gene therapy trial on hold    p562
doi:10.1038/nbt0718-562

Merck vaccine heads Ebola countermeasures    pp563 - 565
Cormac Sheridan
doi:10.1038/nbt0718-563a

Gates unveils biotech-within-a-charity    p563
doi:10.1038/nbt0718-563b

Saying aye to the artificial iris    p565
doi:10.1038/nbt0718-565

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Correspondence

 

KBase: The United States Department of Energy Systems Biology Knowledgebase    pp566 - 569
Adam P Arkin, Robert W Cottingham, Christopher S Henry, Nomi L Harris, Rick L Stevens et al.
doi:10.1038/nbt.4163

The 160K Natural Organism Library, a unique resource for natural products research    pp570 - 573
Siew Bee Ng, Yoganathan Kanagasundaram, Hao Fan, Prakash Arumugam, Birgit Eisenhaber et al.
doi:10.1038/nbt.4187

The European Union Court's Advocate General's Opinion and new plant breeding techniques    pp573 - 575
Kai P Purnhagen, Esther Kok, Gijs Kleter, Hanna Schebesta, Richard G F Visser et al.
doi:10.1038/nbt.4174

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Feature

 

Public biotech in 2017—the numbers    pp576 - 584
Chris Morrison & Riku Lähteenmäki
doi:10.1038/nbt.4175

Patents

Patent mining and landscaping of emerging recombinant factor VIII through network analysis    pp585 - 590
Cristiano Gonçalves Pereira, Virgínia Picanco-Castro, Dimas Tadeu Covas & Geciane Silveira Porto
doi:10.1038/nbt.4178

Recent patents in organoids and organs-on-chips    p591
doi:10.1038/nbt.4190

News and Views

 

Cardiomyocytes remuscularize the heart    pp592 - 593
Wolfram-Hubertus Zimmermann
doi:10.1038/nbt.4186

A new route to synthetic DNA    pp593 - 595
Adam Clore
doi:10.1038/nbt.4185

Research Highlights    p595
doi:10.1038/nbt.4176

Reportage from the gut    p596
Irene Jarchum
doi:10.1038/nbt.4177

Biotechnology
JOBS of the week
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Biotechnology
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International Colloquium on Biotechnology & Industrial Revolution
15.11.18
Dubai, UAE
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Research

 
Articles

Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates    pp597 - 605
Yen-Wen Liu, Billy Chen, Xiulan Yang, James A Fugate, Faith A Kalucki et al.
doi:10.1038/nbt.4162
Cardiomyocyte transplantation after heart attack improves contractile function in monkeys.

Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass    pp606 - 613
Ruwan Gunaratne, Shekhar Kumar, James W Frederiksen, Steven Stayrook, Jens L Lohrmann et al.
doi:10.1038/nbt.4153
An aptamer is combined with a drug to prevent clot formation in a model of cardiopulmonary bypass.

Precise, automated control of conditions for high-throughput growth of yeast and bacteria with eVOLVER    pp614 - 623

doi:10.1038/nbt.4151
Continuous culturing of individually controlled growth experiments in parallel and at high-throughput is enabled with an automated DIY platform.

Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains    pp624 - 631
Ross Thyer, Raghav Shroff, Dustin R Klein, Simon d'Oelsnitz, Victoria C Cotham et al.
doi:10.1038/nbt.4154
Selenocysteine is efficiently incorporated into recombinant proteins using evolved Escherichia coli strains.

Letters

Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos    pp632 - 637
Bin Gu, Eszter Posfai & Janet Rossant
doi:10.1038/nbt.4166
Knock-in mice with precise insertions are efficiently generated through delivery of CRISPR–Cas9 to two-cell embryos.

Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylation-dependent interactions    pp638 - 644
Karl W Barber, Paul Muir, Richard V Szeligowski, Svetlana Rogulina, Mark Gerstein et al.
doi:10.1038/nbt.4150
Screening with bacteria encoding human serine phosphopeptides reveals phosphoprotein interactions.

De novo DNA synthesis using polymerase-nucleotide conjugates    pp645 - 650
Sebastian Palluk, Daniel H Arlow, Tristan de Rond, Sebastian Barthel, Justine S Kang et al.
doi:10.1038/nbt.4173
An enzymatic approach enables synthesis of a defined DNA sequence using TdT with reversibly tethered dNTPs.

 

Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed    pp651 - 659
Ksenya Kveler, Elina Starosvetsky, Amit Ziv-Kenet, Yuval Kalugny, Yuri Gorelik et al.
doi:10.1038/nbt.4152
Interactions between hundreds of immune cells and cytokines in disease are mined from PubMed.

Careers and Recruitment

 

As life sciences sector's positive momentum continues, so do executive compensation levels    pp661 - 664
Bruce Rychlik
doi:10.1038/nbt.4188

People

People    p666
doi:10.1038/nbt.4191

Corrigenda

 

Corrigendum: Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea    p660
Robert M Bowers, Nikos C Kyrpides, Ramunas Stepanauskas, Miranda Harmon-Smith, Devin Doud et al.
doi:10.1038/nbt0718-660a

Corrigendum: Assisted reproductive technologies to prevent human mitochondrial disease transmission    p660
Andy Greenfield, Peter Braude, Frances Flinter, Robin Lovell-Badge, Caroline Ogilvie et al.
doi:10.1038/nbt0718-660b

Errata

 

Erratum: Random access in large-scale DNA data storage    p660
Lee Organick, Siena Dumas Ang, Yuan-Jyue Chen, Randolph Lopez, Sergey Yekhanin et al.
doi:10.1038/nbt0718-660c

Erratum: California voters and CIRM—will lightning strike twice?    p660
Laura DeFrancesco
doi:10.1038/nbt0718-660d

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