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Nature Reviews Genetics Contents July 2018 Volume 19 Number 7

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Nature Reviews Genetics

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TABLE OF CONTENTS

July 2018 Volume 19, Issue 7

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Research Highlights
Reviews
 
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First-line genomic diagnosis of mitochondrial disorders    pp399 - 400
F. Lucy Raymond, Rita Horvath & Patrick F. Chinnery
doi:10.1038/s41576-018-0022-1

Research Highlights

 

Scrutinizing spliceosomes    p401
Rebecca Furlong
doi:10.1038/s41576-018-0019-9

A breath-holding adaptation    pp402 - 403
Michelle Trenkmann
doi:10.1038/s41576-018-0014-1

A new study in Cell reports genomic selection of physiological adaptations to hypoxia in breath-hold diving marine hunter–gatherers, the indigenous Bajau people of Southeast Asia.

 

Some like it hot — sex determination in turtles    pp402 - 403
Linda Koch
doi:10.1038/s41576-018-0023-0

A recent study in Science reports the mechanism by which temperature affects sex determination in the red-eared slider turtle, Trachemys scripta elegans.

 

Estimating heritability without genetic testing    p403
Linda Koch
doi:10.1038/s41576-018-0021-2

A new study reports the use of electronic health records as a resource for studying the heritability of traits.

 

Nature Reviews Genetics
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Reviews

 

Prions, prionoids and protein misfolding disorders    pp405 - 418
Claudia Scheckel & Adriano Aguzzi
doi:10.1038/s41576-018-0011-4

Parallels are increasingly being drawn between prion diseases and other aggregate-mediated neurodegenerative disorders. While prion diseases are a distinct subclass of protein misfolding disorders (PMDs), a better understanding of shared mechanisms is likely to benefit treatment of all PMDs.

 

The transition to modernity and chronic disease: mismatch and natural selection    pp419 - 430
Stephen Corbett, Alexandre Courtiol, Virpi Lummaa, Jacob Moorad & Stephen Stearns
doi:10.1038/s41576-018-0012-3

The authors review the changes in life history traits brought forth by the Industrial Revolution and the evidence for antagonistic pleiotropic effects, whereby genetic variants associated with higher fitness in the past now predispose to diseases such as cancer and coronary artery disease.

 

Heterogeneity and specialized functions of translation machinery: from genes to organisms    pp431 - 452
Naomi R. Genuth & Maria Barna
doi:10.1038/s41576-018-0008-z

Variation in the composition of translation complexes may serve as a means to regulate gene expression. How translation of select transcripts is achieved by specialized components and the role of this form of dynamic control of gene expression in disease are reviewed.

 

Structural variation in the 3D genome    pp453 - 467
Malte Spielmann, Darío G. Lupiáñez & Stefan Mundlos
doi:10.1038/s41576-018-0007-0

Recent studies show that structural variation can alter the genome architecture, leading to changes in the regulation of gene expression that cause disease. The authors review the role of genetic structural variation in disease and the pathogenic potential of changes to the 3D genome.

 

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