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donderdag 28 juni 2018

Nature Reviews Drug Discovery contents July 2018 Volume 17 Number 7 pp 455-527

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Nature Reviews Drug Discovery

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TABLE OF CONTENTS

July 2018 Volume 17, Issue 7

Comment
News and Analysis
Research Highlights
Reviews
 
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Comment

 

Translating translation    pp455 - 456
Christopher P. Austin
doi:10.1038/nrd.2018.27
The term 'translation' has emerged as a dominant concept in biomedical science over the last decade, but confusion around what the term means, and how it differs from translational research and translational science, is common. This article aims to help address this issue by clarifying the distinctions.

News and Analysis

 

First GPCR-directed antibody passes approval milestone    pp457 - 459
Elie Dolgin
doi:10.1038/nrd.2018.103

News in Brief

FDA approves Eli Lilly's baricitinib    p460
Asher Mullard
doi:10.1038/nrd.2018.112

mRNA vaccines get another booster    p460
Asher Mullard
doi:10.1038/nrd.2018.113

Ebola outbreak prompts experimental drug rollout    p460
Asher Mullard
doi:10.1038/nrd.2018.114

Biobusiness Briefs

Market watch: Upcoming catalysts in Q3 2018    p461
Karen Nguyen
doi:10.1038/nrd.2018.108

An Audience With

Amy Abernethy    pp462 - 464
doi:10.1038/nrd.2018.101
Amy Abernethy, CSO at Flatiron Health, talks about how cleaned up and curated real-world data stands to transform clinical trials, drug regulation, competition in the health-care market and drug prices.

From the analyst's couch

The global landscape of cancer cell therapy    pp465 - 466
Jun Tang, Vanessa M. Hubbard-Lucey, Laura Pearce, Jill O'Donnell-Tormey & Aiman Shalabi
doi:10.1038/nrd.2018.74
How many cancer cell therapies are being developed? To harmonize efforts in this arena, the Cancer Research Institute has curated a database that includes all cell therapies in development.

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Research Highlights

 

Stroke: Opening the therapeutic window    p467
Sarah Crunkhorn
doi:10.1038/nrd.2018.98

Cancer: Re-educating tumour-associated macrophages with nanoparticles    p468
Megan Cully
doi:10.1038/nrd.2018.102

Infectious diseases: The painful path to avoiding the immune system    p469
M. Teresa Villanueva
doi:10.1038/nrd.2018.100

Lead identification: The importance of residual complexity    p470
Rebecca Kelsey
doi:10.1038/nrd.2018.104

In Brief

Cancer: Minimizing metastasis    p470
Sarah Crunkhorn
doi:10.1038/nrd.2018.105

Infectious disease: Alphavirus receptor identified    p470
Sarah Crunkhorn
doi:10.1038/nrd.2018.106

Autoimmune disease: Aryl hydrocarbon receptor suppresses inflammation    p470
Sarah Crunkhorn
doi:10.1038/nrd.2018.107

Drug Discovery
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Reviews

 

Cryo-EM in drug discovery: achievements, limitations and prospects    pp471 - 492
Jean-Paul Renaud, Ashwin Chari, Claudio Ciferri, Wen-ti Liu, Hervé-William Rémigy et al.
doi:10.1038/nrd.2018.77
Recent technological advances with cryo-electron microscopy (cryo-EM) — a biophysical technique that can be used to determine the structure of biological macromolecules and assemblies — have raised hopes that it might soon become an important tool for drug discovery, particularly for 'intractable' targets that are still not accessible to analysis by X-ray crystallography. This article describes these advances and critically assesses their relevance for drug discovery.

Advances and innovations in haemophilia treatment    pp493 - 508
Rob Peters & Tim Harris
doi:10.1038/nrd.2018.70
New therapies in development for haemophilia — including gene therapies, proteins with extended half-lives and inhibitors of natural anticoagulants — look poised to change the management of this disease. In this Review, Peters and Harris discuss recent progress, including the hurdles that still need to be overcome in order to translate these advances into routine clinical use.

The promise and challenges of immune agonist antibody development in cancer    pp509 - 527
Patrick A. Mayes, Kenneth W. Hance & Axel Hoos
doi:10.1038/nrd.2018.75
Co-stimulatory receptors mediate the anticancer immune response. This Review discusses the current efforts in targeting co-stimulatory receptors with agonist antibodies and the landscape of agonist antibodies in clinical development for cancer treatment.

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