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woensdag 13 juni 2018

Nature Reviews Cardiology - Table of Contents alert Volume 15 Issue 7

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Nature Reviews Cardiology

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July 2018 Volume 15, Issue 7

Research Highlights
News & Views

Research Highlights


Dynamics of fibroblast activation in the infarcted heart    p379
Alexandra Le Bras

Young women have worse outcomes after STEMI    p380
Gregory B. Lim

Breast cancer therapy and cardiac mortality    p380
Gregory B. Lim

Fitness ameliorates genetic risk of heart disease    p380
Gregory B. Lim

Atherosclerosis linked to faulty DNA repair in VSMCs    p380
Caroline Barranco

Selenoprotein P – a new player in PAH    p381
Irene Fernández-Ruiz

Treatment of PAH with a PPAR? agonist    p381
Gregory B. Lim

Ambulatory versus clinic BP values    p381
Gregory B. Lim

Exosome-based therapy to repair the injured heart    p382
Alexandra Le Bras

Efficacy of cardiac contractility modulation confirmed    p382
Irene Fernández-Ruiz


News & Views


Exercising engineered heart muscle to maturity    pp383 - 384
Donghui Zhang & William T. Pu



Mechanisms of physiological and pathological cardiac hypertrophy    pp387 - 407
Michinari Nakamura & Junichi Sadoshima

Adult cardiac hypertrophy initially develops as an adaptive response to an increased workload, but this physiological growth can ultimately lead to pathological hypertrophy and disease. In this Review, Nakamura and Sadoshima summarize the characteristics and underlying mechanisms of physiological and pathological hypertrophy, and discuss possible therapeutic strategies targeting these pathways to prevent or reverse pathological hypertrophy.


Revascularization in stable coronary disease: evidence and uncertainties    pp408 - 419
Demosthenes G. Katritsis, Daniel B. Mark & Bernard J. Gersh

In this Review, Katritsis and colleagues discuss the major factors underlying the clinical decision to perform revascularization in patients with stable coronary artery disease and examine the use and limitations of existing evidence on the choice for, and preferred methods of, revascularization, namely, CABG surgery versus percutaneous coronary intervention.


Pathophysiological coronary and microcirculatory flow alterations in aortic stenosis    pp420 - 431
Michael Michail, Justin E. Davies, James D. Cameron, Kim H. Parker & Adam J. Brown

This Review highlights the pathophysiology underlying changes in coronary blood flow and the role of functional assessment in patients with high-gradient, high-flow aortic stenosis. Michail and colleagues also discuss factors that influence the immediate and long-term consequences of stenosis treatment.


Influence of urban and transport planning and the city environment on cardiovascular disease    pp432 - 438
Mark J. Nieuwenhuijsen

This Review describes the relationship between urban and transport planning and the city environment, the main cardiovascular risk factors (including physical activity, hypertension, and obesity), and cardiovascular disease and mortality. Improved city planning that promotes physical activity, reduces levels of air pollution and noise, and increases green space could decrease the burden of cardiovascular disease.


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