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donderdag 31 mei 2018

Nature Reviews Urology - Table of Contents alert Volume 15 Issue 6

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Nature Reviews Urology

June 2018 Volume 15, Issue 6

Research Highlights
News & Views
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Research Highlights


Controlling mutational chaos    p335
Clemens Thoma

Cryo combo augments ICI    p336
Annette Fenner

Treating vulvovaginal symptoms    pp336 - 337
Louise Stone

Macropinocytosis for proliferation    pp336 - 337
Rebecca Kelsey

AR involved in sunitinib resistance    p337
Louise Stone

Nature Reviews Urology
JOBS of the week
Multiple Faculty Positions at ShanghaiTech University
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The 4th Friends of Israel Urological Symposium
Tel Aviv, Israel
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News & Views


Prostate MRI can be accurate but can variability be reduced?    pp339 - 340
Rajan T. Gupta & Andrew B. Rosenkrantz

Two methods of prediction signatures    pp340 - 342
Robert T. Jones & Dan Theodorescu

Second-generation antiandrogens in nonmetastatic CRPC    pp342 - 344
Robert Chandler & Johann de Bono



Unravelling disparate roles of NOTCH in bladder cancer    pp345 - 357
Akihiro Goriki, Roland Seiler, Alexander W. Wyatt, Alberto Contreras-Sanz, Akshay Bhat et al.

The Notch pathway has been shown to act in both an oncogenic and a tumour-suppressive manner depending on its cellular context, and blocking or restoring the Notch pathway could offer a novel therapeutic target in patients with bladder cancer. In this Review, the authors describe what is known about Notch in cancer and discuss the role and potential of this signalling pathway in bladder cancer.


Regulation of masculinization: androgen signalling for external genitalia development    pp358 - 368
Shoko Matsushita, Kentaro Suzuki, Aki Murashima, Daiki Kajioka, Alvin Resultay Acebedo et al.

The biology of masculinization is important for understanding embryonic developmental processes involved in the development of the male reproductive tract, genitalia and tumorigenesis of prostate cancer. In this Review, the authors describe our current understanding of the regulation of masculinization.


Genetics of male infertility    pp369 - 384
Csilla Krausz & Antoni Riera-Escamilla

Male infertility is a multifactorial pathological condition, and its genetic landscape is highly complex. Here, Krausz and Riera-Escamilla describe our current understanding of the genetics of male infertility and the clinical implications of this knowledge.




Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis    pp386 - 393
Cagatay G√ľnes, Felix Wezel, Jennifer Southgate & Christian Bolenz

In this Perspectives, the authors present a new model of urothelial carcinogenesis that incorporates the role of telomerase activation. They also highlight the potential of targeting telomerase as a therapeutic approach for bladder cancer.


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