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woensdag 23 mei 2018

Nature Reviews Rheumatology - Table of Contents alert Volume 14 Issue 6

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Nature Reviews Rheumatology

June 2018 Volume 14, Issue 6

Research Highlights
News & Views

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Research Highlights


Synergy of environmental and genetic risk in RA    p319
Nicholas J. Bernard

Denosumab shows promise for GIOP    p320
Sarah Onuora

Triple therapy boosts survival in catastrophic APS    p320
Sarah Onuora

Obesity hampers effects of anti-TNF agents    p320
Sarah Onuora

Flares not linked to ultrasound findings in JIA    p320
Sarah Onuora

Surprising safety outcomes of urate-lowering therapy    p320
Jessica McHugh

Selective p38a MAPK inhibitor shows promise    p321
Jessica McHugh

Drugs deliver themselves during flares    p321
Joanna Collison

Bacterial orthologues of Ro60 trigger disease    p322
Joanna Collison

Fyn-ding a target for OA therapy    p322
Nicholas J. Bernard

Nature Reviews Rheumatology
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News & Views


Optimization of CVD prevention in psoriatic arthritis    pp323 - 324
Anne Grete Semb & Silvia Rollefstad

Neurobiological similarities between RA and fibromyalgia    pp324 - 325
Fabiola Atzeni & Piercarlo Sarzi-Puttini



Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes    pp327 - 340
Francisco J. Blanco, Ana M. Valdes & Ignacio Rego-PĂ©rez

Mitochondrial dysfunction and mitochondrial DNA (mtDNA) influence several molecular processes underlying the pathogenesis of osteoarthritis (OA), and mtDNA variants are associated with the development and progression of knee OA, pointing to a role for mtDNA variation in OA pathogenesis and its phenotypic presentation.


An update on the genetics of hyperuricaemia and gout    pp341 - 353
Tanya J. Major, Nicola Dalbeth, Eli A. Stahl & Tony R. Merriman

In this Review, the authors summarize the results of genetics studies that confirm the importance of modulating urate levels in gout pathophysiology, and discuss how these discoveries could be applied to the treatment of hyperuricaemia and gout.


Biomarkers as drug development tools: discovery, validation, qualification and use    pp354 - 362
Virginia B. Kraus

The use of biomarkers for drug development, clinical investigation and management is fundamental to the success of molecular medicine. This Review discusses the framework for the development of biomarkers as drug development tools, including discovery, analytical validation, clinical qualification and utilization.


Axial disease in psoriatic arthritis and ankylosing spondylitis: a critical comparison    pp363 - 371


Axial disease occurs in psoriatic arthritis (PsA) and ankylosing spondylitis, but questions remain over whether axial PsA is a distinct disease. In this Review, the authors address the current state of knowledge concerning axial PsA and propose a research agenda.




The role of radiography and MRI for eligibility assessment in DMOAD trials of knee OA    pp372 - 380


In this Perspectives article, Roemer et al. argue that the time has come to use MRI, rather than radiography, as the primary imaging modality for defining eligibility criteria for clinical trials of potential disease-modifying osteoarthritis drugs (DMOADs).


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