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vrijdag 18 mei 2018

Nature Reviews Clinical Oncology - Table of Contents alert Volume 15 Issue 6

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Nature Reviews Clinical Oncology

June 2018 Volume 15, Issue 6

Research Highlights
News & Views



The paradox of precision medicine    pp341 - 342
Jonathan Kimmelman & Ian Tannock

Research Highlights


CheckMate 214 — a winning combination?    p343
Diana Romero

Obesity associated with resistance to anti-angiogenic therapy    p344
David Killock

Postoperative chemoradiotherapy versus radiotherapy for high-risk cutaneous disease    p344
David Killock

New subtypes of high-grade neuroendocrine tumours revealed    p344
David Killock

Venetoclax–rituximab holds substantial promise in CLL    pp344 - 345
David Killock

Encorafenib — a new agent for advanced-stage disease    pp344 - 345
Peter Sidaway

MRI improves diagnosis    p345
Peter Sidaway

Improved pain management     p346
Diana Romero

DDR signature to predict response to ICI    p346
Diana Romero

PET imaging reveals EGFR mutation status    p346
Peter Sidaway

Nature Reviews Clinical Oncology
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News & Views


Triple-negative breast cancers — a panoply of cancer types    pp347 - 348
Fresia Pareja & Jorge S. Reis-Filho

Precision oncology in non-small-cell lung cancer: opportunities and challenges    pp348 - 349
Chul Kim & Giuseppe Giaccone

Does nonmetastatic castration-resistant prostate cancer still exist?    pp350 - 351
Celestia S. Higano



The emerging clinical relevance of genomics in cancer medicine    pp353 - 365
Michael F. Berger & Elaine R. Mardis

Developments in genomic sequencing technologies have enabled increasing amounts of information on the genomes of individual cancers to be revealed. At the same time, increasing numbers of therapies targeting specific genomic alterations are being made available, necessitating the use of genomics to diagnose and treat patients with cancer. In this Review, the authors describe the emerging clinical relevance of genomics in oncology, in addition to the many challenges that currently preclude routine clinical use.


Targeting the tumour stroma to improve cancer therapy    pp366 - 381
Kenneth C. Valkenburg, Amber E. de Groot & Kenneth J. Pienta

The tumour stroma is a component of the tumour microenvironment and has crucial roles in tumour initiation, progression, and metastasis. Most anticancer therapies target cancer cells specifically, but the tumour stroma can promote resistance to such therapies. Herein, the authors provide an overview of the complex cancer cell–tumour stroma interactions and discuss how novel treatment strategies should combine anticancer and antistromal agents.




The gut microbiota influences anticancer immunosurveillance and general health    pp382 - 396
Bertrand Routy, Vancheswaran Gopalakrishnan, Romain Daillère, Laurence Zitvogel, Jennifer A. Wargo et al.

Emerging evidence indicates that the composition of the intestinal microbiota influences anticancer immunosurveillance and therefore the effectiveness of anticancer therapies, especially immune-checkpoint inhibitors. Herein, key contributors to this field of research discuss these connections between gut bacteria, anticancer immunity, and general health, with a focus on specific bacterial species consistently associated with favourable clinical outcomes of anticancer immunotherapy, and explore the potential mechanisms.


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