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Nature Biotechnology Contents: Volume 36 pp 373 - 476

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TABLE OF CONTENTS

May 2018 Volume 36, Issue 5

Editorial
News
Bioentrepreneur
Opinion and Comment
Features
News and Views
Research
Careers and Recruitment
 
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Editorial

Top

Unleashing biotech's crouching tiger   p373
doi:10.1038/nbt.4149
With a massive expansion in healthcare coverage, biotech's next big boom could occur in India. But this revolution will not be globalized[mdash]it will be about serving national needs.
 

News

Top

Allogene and Celularity move CAR-T therapy off the shelf   pp375 - 377
Cormac Sheridan
doi:10.1038/nbt0518-375
 

Cytokine resurrection: engineered IL-2 ramps up immuno-oncology responses   pp378 - 379
Ken Garber
doi:10.1038/nbt0518-378
 

2020 African American genomes   p380
doi:10.1038/nbt0518-380a
 

Indian biotech sector readies for liftoff   pp380 - 381
Killugudi Jayaraman
doi:10.1038/nbt0518-380b
 

Patent challenges to antibody and gene-therapy firms on the rise   pp382 - 383
Charlotte Harrison
doi:10.1038/nbt0518-382
 

Trump threatens then signs, a win for FDA, NIH   p383
doi:10.1038/nbt0518-383
 

To keep biotechs trading at home, China pilots new stock market rules   p384
Shannon Ellis
doi:10.1038/nbt0518-384
 

Around the world in a month   p385
doi:10.1038/nbt0518-385
 

 

Top

Drug pipeline: 1Q18   p386
Laura DeFrancesco
doi:10.1038/nbt.4142
 


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Bioentrepreneur

Top
Building a Business

A rich resource   pp387 - 390
Ahmet-Hamdi Cavusoglu, Elizabeth Beerman and Orin Herskowitz
doi:10.1038/nbt.4130
 

Opinion and Comment

Top
Correspondence

Alternative models for sharing confidential biomedical data   pp391 - 392
Justin Guinney and Julio Saez-Rodriguez
doi:10.1038/nbt.4128
 

Features

Top

Bringing up baby   pp393 - 401
Brady Huggett
doi:10.1038/nbt.4135
More investors are building companies from scratch, with more money than any time in biotech's history.
 

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First rounders: John Maraganore   p401
John Maraganore
doi:10.1038/nbt.4145
 

 

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Patentability of antibodies for therapeutic use in Europe   pp402 - 405
Claudio Germinario, Sara Bertoli, Patrizia Rampinelli and Maurizio Cini
doi:10.1038/nbt.4134
General guidelines are presented on the types of patent protection available for inventions arising from research in the field of monoclonal antibodies, using concepts drawn from European case law and expert practice.
 

Feature

Top
Patents

Recent patents in biomedical imaging   p406
doi:10.1038/nbt.4146
 

News and Views

Top

Brain organoids get vascularized   pp407 - 408
Madeline A Lancaster
doi:10.1038/nbt.4133
Transplantation of cerebral organoids into the mouse brain overcomes some limitations of in vitro systems.

See also: Research by Mansour et al.

Boosting the power of single-cell analysis   pp408 - 409
Lu Wen and Fuchou Tang
doi:10.1038/nbt.4131
Data sets from different single-cell RNA-seq experiments are combined with reduced technical error.

See also: Research by Butler et al. | Research by Haghverdi et al.

All the skin that's fit to print   p410
Irene Jarchum
doi:10.1038/nbt.4129
 

Research Highlights   p410
doi:10.1038/nbt.4139
 

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Research

Top
Analysis

Integrating single-cell transcriptomic data across different conditions, technologies, and species   pp411 - 420
Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi and Rahul Satija
doi:10.1038/nbt.4096
A new computational approach enables integrative analysis of disparate single-cell RNA-sequencing data sets by identifying shared patterns of variation between cell subpopulations.

See also: News and Views by Wen & Tang

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors   pp421 - 427
Laleh Haghverdi, Aaron T L Lun, Michael D Morgan and John C Marioni
doi:10.1038/nbt.4091
Differences in gene expression between individual cells of the same type are measured across batches and used to correct technical artifacts in single-cell RNA-sequencing data.

See also: News and Views by Wen & Tang

Brief Communications

Highly scalable generation of DNA methylation profiles in single cells   pp428 - 431
Ryan M Mulqueen, Dmitry Pokholok, Steven J Norberg, Kristof A Torkenczy, Andrew J Fields et al.
doi:10.1038/nbt.4112
Methylation profiling of single cells in high throughput achieves read-alignment rates approaching bulk cell population studies.
 

Articles

An in vivo model of functional and vascularized human brain organoids   pp432 - 441
Abed AlFatah Mansour, J Tiago Goncalves, Cooper W Bloyd, Hao Li, Sarah Fernandes et al.
doi:10.1038/nbt.4127
Human cerebral organoids undergo vascularization and maturation in the mouse brain.

See also: News and Views by Lancaster

Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain   pp442 - 450
Bushra Raj, Daniel E Wagner, Aaron McKenna, Shristi Pandey, Allon M Klein et al.
doi:10.1038/nbt.4103
scGESTALT enables large-scale characterization of cell types and lineage relationships during vertebrate brain development.
 

Fast, long-term, super-resolution imaging with Hessian structured illumination microscopy   pp451 - 459
Xiaoshuai Huang, Junchao Fan, Liuju Li, Haosen Liu, Runlong Wu et al.
doi:10.1038/nbt.4115
An improved image reconstruction algorithm increases time resolution and maximal imaging time for super-resolution microscopy.
 

Deep learning massively accelerates super-resolution localization microscopy   pp460 - 468
Wei Ouyang, Andrey Aristov, Mickael Lelek, Xian Hao and Christophe Zimmer
doi:10.1038/nbt.4106
Accelerating PALM/STORM microscopy with deep learning allows super-resolution imaging of >1,000 cells in a few hours.
 

Letter

Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars   pp469 - 473
Bastiaan Spanjaard, Bo Hu, Nina Mitic, Pedro Olivares-Chauvet, Sharan Janjuha et al.
doi:10.1038/nbt.4124
LINNAEUS reconstructs developmental lineages using RNA sequencing data and lineage markers from the same single cells.
 

Careers and Recruitment

Top

First-quarter biotech job picture   p475
Michael Francisco
doi:10.1038/nbt.4141
 

People

People   p476
doi:10.1038/nbt.4144
 

Top
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