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maandag 9 april 2018

The Lancet: [Articles] Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV ...

[Articles] Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study
Antibody responses to single-dose rVSV-ZEBOV vaccination are sustained across dose ranges and settings, a key criterion in countries where booster vaccinations would be impractical.
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[Comment] Ebola virus vaccination and the longevity of total versus neutralising antibody response—is it enough?
The rapid development of Ebola virus vaccine candidates in the face of the 2013–16 western Africa outbreak resulted in deployment of experimental vaccines, which were largely well tolerated and immunogenic. However, questions remain about the longevity of immune responses induced by Ebola virus vaccines. Several phase 1, 2, and 3 clinical trials have been done for several Ebola virus vaccines, but data from animal-model studies suggest immunity via these vaccines might be short-lived. In The Lancet Infectious Diseases, Angela Huttner and colleagues1 report that human participants from multiple sites across Europe and Africa maintain increased Ebola virus-specific human antibody responses for 1–2 years after inoculation with a recombinant vesicular stomatitis virus (rVSV) vaccine expressing the Zaire Ebola virus glycoprotein (rVSV-ZEBOV).
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[Media Watch] A place for compassion
What is the legacy of the generation of gay men who faced the emergence of AIDS in the 1980s? Can new generations relate and learn from those who went through the trauma of seeing friends and lovers get ill and die, abandoned by society? And how did the experiences and fights of those who lived through the ravages caused by AIDS shape the current social and political identity of gay communities? These difficult questions are raised in The Inheritance, Matthew Lopez's ambitious new play in two parts receiving its world premiere at the Young Vic, under Stephen Daldry's direction.
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[Articles] Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: a WHO-coordinated, prospective, international, observational cohort study
Irrespective of resistance, populations in malaria endemic areas should continue to use long-lasting insecticidal nets to reduce their risk of infection. As nets provide only partial protection, the development of additional vector control tools should be prioritised to reduce the unacceptably high malaria burden.
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[Comment] Measuring the effect of insecticide resistance: are we making progress?
Exceptional global efforts to fight malaria have greatly reduced the disease burden by more than 500 million cases since 2000 in sub-Saharan Africa.1 These gains are partly ascribed to vector control using long-lasting insecticidal nets and indoor residual spraying—core interventions within the framework of integrated vector management2—thus renewing the optimism and prioritisation of universal coverage for vector control in the Global Technical Strategy for Malaria 2016–2030.3 The 70th World Health Assembly approved the Global Vector Control Response 2017–2030 that set ambitious but attainable goals, and prioritised four strategic approaches, including evidence-driven scale-up and integration of vector control tools to maximize the effect on disease and reinvigorate vector control.
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