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The EMBO Journal Table of Contents for 13 April 2018; Vol. 37, No. 8

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13 April 2018 | Volume 37, Number 8 Submit


Table of Contents

Editorial
News & Views
Articles
COVER

Volume 37, Number 8



Editorial

Life Science Alliance, a new peer reviewed open access platform for and by the research community to increase the efficacy of publishing high quality research findings.

Bernd Pulverer
Published online 03.04.2018

News & Views
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Mouse genetics combined with cell culture and transcriptome analyses highlight dependence of satellite cell activation on PI3K–mTORC1–Jun signalling.

Frederic Relaix and Léo Machado
Published online 26.03.2018

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New work reveals a striking role for cholesterol in controlling an inflammatory pain‐mediating sodium channel via lipid rafts.

Shihab Shah and Nikita Gamper
Published online 23.03.2018

Articles
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Stimulation of the cGAS‐STING innate immunity pathway by cytosolic DNA leads to TBK1‐mediated phosphorylation of the selective autophagy receptor p62, directing ubiquitinated STING to autophagosomes and degradation.

Thaneas Prabakaran, Chiranjeevi Bodda, Christian Krapp, Bao‐cun Zhang, Maria H Christensen, Chenglong Sun, Line Reinert, Yujia Cai, Søren B Jensen, Morten K Skouboe, Jens R Nyengaard, Craig B Thompson, Robert Jan Lebbink, Ganes C Sen, Geert van Loo, Rikke Nielsen, Masaaki Komatsu, Lene N Nejsum, Martin R Jakobsen, Mads Gyrd‐Hansen and Søren R Paludan
Published online 01.03.2018

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Phosphatidylinositol 3‐kinase (PI3K)–mTORC1–c‐Jun signaling is essential for muscle stem cell quiescence exit and tissue repair upon injury.

Gang Wang, Han Zhu, Chenghao Situ, Lifang Han, Youqian Yu, Tom H Cheung, Kai Liu and Zhenguo Wu
Published online 26.03.2018

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An unexpected pain transmission function of cholesterol in skin tissue and sensory neurons expands its pathophysiological roles beyond metabolism and vascular diseases.

Muriel Amsalem, Corinne Poilbout, Géraldine Ferracci, Patrick Delmas and Francoise Padilla
Published online 19.02.2018

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A new class of c‐di‐GMP phosphodiesterases in Escherichia coli are regulated by posttranslational modifications in the periplasm to reduce biofilm formation.

Susanne Herbst, Martin Lorkowski, Olga Sarenko, Thi Kim Loan Nguyen, Tina Jaenicke and Regine Hengge
Published online 07.03.2018 Open Access

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Regulated TACC3 recruitment by clathrin involves phosphorylation‐mediated conformational changes rather than direct phosphate group recognition, exemplifying a flexible alternative mechanism of phospho‐regulation.

Selena G Burgess, Manjeet Mukherjee, Sarah Sabir, Nimesh Joseph, Cristina Gutiérrez‐Caballero, Mark W Richards, Nicolas Huguenin‐Dezot, Jason W Chin, Eileen J Kennedy, Mark Pfuhl, Stephen J Royle, Fanni Gergely and Richard Bayliss
Published online 06.03.2018 Open Access

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The cold‐induced kinase OST1 phosphorylates components of the nascent polypeptide associated complex, leading to stabilisation of cold response factors CBFs and increased plant freezing tolerance.

Yanglin Ding, Yuxin Jia, Yiting Shi, Xiaoyan Zhang, Chunpeng Song, Zhizhong Gong and Shuhua Yang
Published online 05.03.2018

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In contrast to its global role in RNA polymerase II pausing and elongation in yeast, Spt5 depletion in mouse triggers dissociation of Pol II at a specific region 15–20 kb downstream from the promoter.

Johanna Fitz, Tobias Neumann and Rushad Pavri
Published online 07.03.2018 Open Access

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The long noncoding RNA lncKdm2b promotes activity of the chromatin remodeling complex SRCAP, thereby promoting Zbtb3 expression and Nanog‐dependent embryonic stem cell (ESC) renewal and embryonic development.

Buqing Ye, Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Dongdong Zhang, Wei Wu, Pingping Zhu, Yanying Wang, Shuo Wang, Pengyan Xia, Ying Du, Shu Meng, Guanling Huang, Jiayi Wu, Runsheng Chen, Yong Tian and Zusen Fan
Published online 13.03.2018

 
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