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Nature Reviews Nephrology - Table of Contents alert Volume 14 Issue 5

Nature Reviews Nephrology
May 2018 Volume 14 Number 5
Nature Reviews Nephrology cover
2016 2-year Impact Factor 12.146 Journal Metrics 2-year Median 9
In this issue
Research Highlights
News and Views
Also this month
 Featured article:
Mitochondrial dysfunction in diabetic kidney disease
Josephine M. Forbes & David R. Thorburn


Recommend to library

Metabolism: High salt intake as a driver of obesity
Published online: 26 March 2018
p285 | doi:10.1038/nrneph.2018.23


Regeneration: Interstitial-epithelial crosstalk
Published online: 05 March 2018
p286 | doi:10.1038/nrneph.2018.20


Autoimmunity: Increased PGD2 signalling in lupus pathogenesis
Published online: 12 March 2018
p286 | doi:10.1038/nrneph.2018.21


Autoimmunity: IL-17C promotes immune-mediated glomerular disease
Published online: 19 March 2018
p286 | doi:10.1038/nrneph.2018.22



Nature Reviews Nephrology
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Genetics: An integrated genetic analysis of disease
David L. Mattson

Published online: 09 April 2018
p287 | doi:10.1038/nrneph.2018.26

A genome-wide association study (GWAS) of quantitative traits that incorporated data from GWAS of complex diseases provides clues regarding the relationships between genetic loci, intermediate phenotypes and diseases. Together, the data demonstrate pleiotropy, genetic correlation and cell-type specificity of quantitative traits as predictors of multiple complex diseases.
Full Text | PDF

Epidemiology: Chronic disease, cancer, and exercise — a common link
Andrew S. Allegretti & Ravi I. Thadhani

Published online: 26 March 2018
p288 | doi:10.1038/nrneph.2018.24

Advances in precision medicine have greatly improved outcomes for patients with cancer. New findings that demonstrate a substantial contribution of major chronic diseases and disease markers to the risk of cancer incidence and mortality highlight the impact of chronic disease on cancer risk and suggest that chronic diseases should be targeted in cancer prevention strategies.
Full Text | PDF

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Mitochondrial dysfunction in diabetic kidney disease
Josephine M. Forbes & David R. Thorburn

Published online: 19 February 2018
p291 | doi:10.1038/nrneph.2018.9

Dysfunctional mitochondria are postulated to be central to the development and progression of diabetic kidney disease (DKD). Here, the authors review the role of mitochondrial dysfunction in the pathogenesis of DKD and novel therapeutic strategies to target mitochondria and improve kidney function.
Abstract | Full Text | PDF | Supplementary information

Environmental pollution and kidney diseases
Xin Xu, Sheng Nie, Hanying Ding & Fan Fan Hou

Published online: 26 February 2018
p313 | doi:10.1038/nrneph.2018.11

Exposure to environmental pollutants is a major cause of kidney injury and disease worldwide and is a particular problem in the developing world. In this Review, the authors discuss the different environmental pollutants that affect the kidney, and our understanding of the pathogenic mechanisms of environmental pollutants in kidney injury and disease.
Abstract | Full Text | PDF

Angiotensin-converting enzyme in innate and adaptive immunity
Kenneth E. Bernstein et al.

Published online: 26 March 2018
p325 | doi:10.1038/nrneph.2018.15

Angiotensin-converting enzyme (ACE) not only plays a major part in the regulation of blood pressure but also participates in several other physiological functions, including renal development and male reproduction. Here, Bernstein et al. discuss how ACE enhances both innate and adaptive responses by modulating macrophage and neutrophil function.
Abstract | Full Text | PDF | Supplementary information

Use of oral anticoagulants in patients with atrial fibrillation and renal dysfunction
Tatjana S. Potpara, Charles J. Ferro & Gregory Y. H. Lip

Published online: 26 March 2018
p337 | doi:10.1038/nrneph.2018.19

Renal dysfunction and atrial fibrillation (AF) share common risk factors and often coexist. Here, the authors discuss the risks and benefits of use of vitamin K antagonists (VKAs) and non-VKA oral anticoagulants for thromboprophylaxis in patients with coexistent AF and renal dysfunction.
Abstract | Full Text | PDF

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Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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