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Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 15 Issue 5

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Nature Reviews Gastroenterology & Hepatology

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May 2018 Volume 15, Issue 5

Research Highlights
Consensus Statements



CRISPR–Cas-related technologies in basic and translational liver research    pp251 - 252
Chun-Qing Song & Wen Xue

Women and alcoholic liver disease — warning of a silent danger    pp253 - 254
Gyongyi Szabo

Research Highlights


Intestinal tract: A breach in the intestinal barrier during hyperglycaemia    p255
Katrina Ray

In Brief

NASH: Successful phase II trial of FGF19 analogue    p256
Iain Dickson

Viral hepatitis: Maternal tenofovir use does not improve prevention of perinatal HBV transmission    p256
Iain Dickson

Endoscopy: Autofluorescence inferior for dysplasia surveillance    p256
Iain Dickson

Viral hepatitis: OX40 signalling mediates effective HBV immune responses    p256
Hugh Thomas

Nature Reviews Gastroenterology and Hepatology
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Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer    pp257 - 273
José B. Sáenz & Jason C. Mills
The stomach responds to injury via two main patterns, the superficial response and the glandular response. In this Review, Sáenz and Mills discuss cellular plasticity and reprogramming in the stomach in the context of disease (such as gastric cancer) and during repair and homeostasis.

Noninvasive imaging biomarker assessment of liver fibrosis by elastography in NAFLD    pp274 - 282
Elliot B. Tapper & Rohit Loomba
Elastography is the most accurate noninvasive approach to assess liver fibrosis in patients with NAFLD. Here, the authors discuss the benefits and limitations of various elastographic modalities, their role in the optimal management of NAFLD and directions for future research.

Extrahepatic cancers and chronic HCV infection    pp283 - 290
Stanislas Pol, Anaïs Vallet-Pichard & Olivier Hermine
A growing body of evidence suggests that chronic hepatitis C infection is associated with an increased rate of extrahepatic cancers. In this Review, the authors summarize epidemiological studies exploring this relationship and provide insights into the potential mechanisms underlying a causal link.

Consensus Statements


Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal motility disorders    pp291 - 308
Jutta Keller, Gabrio Bassotti, John Clarke, Phil Dinning, Mark Fox et al.
Gastrointestinal motor disorders affect a large proportion of the population worldwide. In this Consensus Statement, the authors describe recommended tests for the investigation of gastric, small bowel and colonic motility, with an emphasis on how best to classify gastrointestinal motor disorders to guide treatment decisions.

Expert consensus document: Advances in the evaluation of anorectal function    pp309 - 323
Emma V. Carrington, S. Mark Scott, Adil Bharucha, François Mion, Jose M. Remes-Troche et al.
Faecal incontinence and evacuation disorders are common and substantially impair quality of life. In this Consensus Statement, the authors describe recommended tests for the evaluation of anorectal function and the clinical relevance of these tests in the management of patients to help guide the practising clinician.



Advances in the physiological assessment and diagnosis of GERD    p323
Edoardo Savarino, Albert J. Bredenoord, Mark Fox, John E. Pandolfino, Sabine Roman et al.

Advances in the management of oesophageal motility disorders in the era of high-resolution manometry: a focus on achalasia syndromes    p323
Peter J. Kahrilas, Albert J. Bredenoord, Mark Fox, C. Prakash Gyawali, Sabine Roman et al.

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