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dinsdag 10 april 2018

Nature Medicine Contents: April 2018 Volume 24 Number 4 pp 375-526

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Nature Medicine

CALL FOR APPLICATIONS: The 2019 Vilcek Prizes for Creative Promise in Biomedical Science

Three $50,000 cash awards for young immigrant biomedical scientists. Learn more about the prizes and apply at VILCEK.ORG.

DEADLINE: June 11, 2018

April 2018 Volume 24, Issue 4

News and Views
Countering Antimicrobial Resistance

This conference will highlight work on understanding the ecology and spread of infectious agents and innovations in screening, therapeutic modalities and new countermeasures to address the spread of organisms resistant to carbapenem or vancomycin as well as multidrug-resistant Mycobacterium tuberculosis.

May 28-29, 2018 | Beijing, China

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Harrington drug discovery research grants - awards up to $700,000

Harrington Discovery Institute at University Hospitals in Cleveland, Ohio invites Full Applications for the 2019 Harrington Scholar-Innovator Award, offering physician-scientists the resources to advance discoveries into medicines. Full Applications are accepted through May 10, 2018. Apply now at HarringtonDiscovery.org/Grant.
Nature Milestone: Anticoagulants from Nature Reviews Cardiology 

This Milestone plots the history of anticoagulant drugs, used to prevent and treat thrombotic disorders in millions of patients worldwide. Fourteen Milestone articles are presented on an interactive timeline with associated multimedia. 

Access free online >> 

Produced with support from: 
Portola Pharmaceuticals, Inc. 

Nature Outlook: Bladder cancer 

After three decades without progress, there is now hope that we can move the needle on treating bladder cancer. 

Access the free Outlook >> 

Produced with support from: 



A checkup for the flu vaccine   p375
Influenza causes almost 650,000 deaths worldwide each year, yet a long-lasting, protective vaccine remains elusive. Global investment—both scientific and financial—in a universal flu vaccine is overdue.


News Features

A tale of two diseases: Aging HIV patients inspire a closer look at Alzheimer's disease   pp376 - 377
Shraddha Chakradhar

Experimenting with blockchain: Can one technology boost both data integrity and patients' pocketbooks?   pp378 - 381
Katharine Gammon

News and Views


A new site of attack for a malaria vaccine   pp382 - 383
Simon J Draper and Matthew K Higgins
A newly discovered antibody epitope on the liver-infective form of the parasite that causes malaria opens new doors for vaccine development.

See also: Article by Tan et al. | Article by Kisalu et al. |

Inflammation weakens HIV prevention   pp384 - 385
Thomas J Hope
The presence of multiple inflammatory cytokines predicts the failure of a topical 1% tenofovir microbicide gel to protect women against HIV infection.

See also: Article by McKinnon et al. |

Predicting leukemia relapse   pp385 - 387
Jose Ignacio Martin-Subero
Mass cytometry of acute B cell lymphoblastic leukemias at diagnosis reveals intrapatient phenotypic heterogeneity and specific signatures that mimic cell developmental stage and predict future relapse.

See also: Article by Good et al. |

Catalyzing the field of precision oncology, one basket at a time   pp387 - 388
William Pao and Imola Fodor
A bedside strategy to overcome the limitations of testing in preclinical models and to determine the role of gene mutations and their targetability directly in patients is presented.

Transplanted neural progenitors bridge gaps to benefit cord-injured monkeys   pp388 - 390
Steven A Goldman
Human neural progenitor cells have been grafted successfully into rhesus monkeys with spinal cord hemisection, resulting in anatomic integration and improved neurological function.

See also: Article by Rosenzweig et al. |

A molecular mechanism governing memory precision   pp390 - 391
Josue Haubrich and Karim Nader
A key molecular mechanism has been identified that dictates whether memory will maintain or lose its details over time and that is relevant in post-traumatic stress disorder and dementia.

See also: Article by Guo et al. |

Nature Medicine
JOBS of the week
Post-doctoral fellow
Washington University School of Medicine, St. Louis
Postdoctoral Research Scholar
UT Southwestern Medical Center
Director, Whitaker Cardiovascular Institute
Boston University
Executive Director, Brown Center for Immunotherapy
Indiana University School of Medicine
Postdoctoral Fellow / Pediatrics - 180000006J
The University of Tennessee Health Science Center (UTHSC)
More Science jobs from
Nature Medicine
International Conference on HIV/AIDS Prevention and Control
Colombo, Sri Lanka
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Current understanding of the human microbiome   pp392 - 400
Jack A Gilbert, Martin J Blaser, J Gregory Caporaso, Janet K Jansson, Susan V Lynch et al.

Animation on CRISPR: Gene editing and beyond

The CRISPR-Cas9 system has revolutionised gene editing, but cutting DNA isn't all it can do.

This Animation, from Nature Methods, explores where CRISPR might be headed next. 

Watch the Animation >> 

Produced with support from: 



A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein   pp401 - 407
Joshua Tan, Brandon K Sack, David Oyen, Isabelle Zenklusen, Luca Piccoli et al.
Volunteers who develop protection against malaria produce potent antibodies binding to a site of vulnerability on the parasite circumsporozoite protein that is absent in vaccines currently being tested in humans

See also: News and Views by Draper & Higgins | Article by Kisalu et al. |

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite   pp408 - 416
Neville K Kisalu, Azza H Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J Flynn et al.
The identification of antibodies targeting a conserved site of vulnerability in the Plasmodium falciparum circumsporozoite protein reveals opportunities for passive prevention of malaria in vulnerable individuals and provides insights for rational vaccine design.

See also: News and Views by Draper & Higgins | Article by Tan et al. |

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia   pp417 - 426
Pankaj Baral, Benjamin D Umans, Lu Li, Antonia Wallrapp, Meghna Bist et al.
Nociceptor sensory neurons suppress innate immunity during bacterial lung infection.

Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy   pp427 - 437
Nisha M Badders, Ane Korff, Helen C Miranda, Pradeep K Vuppala, Rebecca B Smith et al.
A preclinical therapy to treat neurodegeneration is developed that selectively targets the AF-2 domain of the androgen receptor while sparing other functions of this receptor.

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization   pp438 - 449
Nannan Guo, Marta E Soden, Charlotte Herber, Michael TaeWoo Kim, Antoine Besnard et al.
Dynamic regulation of the cytoskeletal factor ABLIM3 controls the precision of memory representations in rodent models of post-traumatic stress disorder and age-related cognitive impairment.

See also: News and Views by Haubrich & Nader |

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia   pp450 - 462
Bin Zhang, Le Xuan Truong Nguyen, Ling Li, Dandan Zhao, Bijender Kumar et al.
In chronic myelogenous leukemia, leukemia stem cell function requires a microRNA that is provided by bone marrow endothelial cells.

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling   pp463 - 473
Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen et al.
Paracrine signaling networks in the breast cancer microenvironment uncover determinants of hormone receptor status and offer opportunities for therapeutic intervention.

Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse   pp474 - 483
Zinaida Good, Jolanda Sarno, Astraea Jager, Nikolay Samusik, Nima Aghaeepour et al.
Mass cytometry of diagnostic biopsies from children with B cell precursor acute lymphoblastic leukemia identifies a signaling state that predicts relapse.

See also: News and Views by Martin-Subero |

Restorative effects of human neural stem cell grafts on the primate spinal cord   pp484 - 490
Ephron S Rosenzweig, John H Brock, Paul Lu, Hiromi Kumamaru, Ernesto A Salegio et al.
In a nonhuman primate model of spinal cord injury, human neural progenitor cell grafts exhibit long-term survival, differentiation, and anatomical integration with host spinal circuitry.

See also: News and Views by Goldman |

Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women   pp491 - 496
Lyle R McKinnon, Lenine J Liebenberg, Nonhlanhla Yende-Zuma, Derseree Archary, Sinaye Ngcapu et al.
In the absence of genital inflammation, tenofovir gel provides superior prevention against HIV acquisition in women.

See also: News and Views by Hope |

Nature Outlook: The future of medicine 

Modern medicine is affording people longer and healthier lives. But researchers want to take improvements in health even further. With advances in gene editing, technology to overcome paralysis and efforts to address high drug costs, the future of medicine is bright. 

Get your free access >> 

Produced with support from Merck KGaA, Darmstadt, Germany 



H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers   pp497 - 504
Michael Seiler, Akihide Yoshimi, Rachel Darman, Betty Chan, Gregg Keaney et al.
The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding spliceosome components.

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer   pp505 - 511
Amritha Nair, Hsiang-Ching Chung, Tingting Sun, Siddhartha Tyagi, Lacey E Dobrolecki et al.
Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.

SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors   pp512 - 517
Leila Dardaei, Hui Qin Wang, Manrose Singh, Paul Fordjour, Katherine X Shaw et al.
Genomic and drug screens identify SHP2 blockade as a therapeutic approach for ALK-rearranged non-small cell lung cancers developing resistance through ALK-mutant-independent mechanisms.

Targeting hepatic glutaminase activity to ameliorate hyperglycemia   pp518 - 524
Russell A Miller, Yuji Shi, Wenyun Lu, David A Pirman, Aditi Jatkar et al.
In mice, elevated glucagon during type 2 diabetes promotes more hepatic glutamine flux and greater gluconeogenesis, while reducing glutamine metabolism in the liver lowers hyperglycemia.



Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types   p525
Ronald J Hause, Colin C Pritchard, Jay Shendure and Stephen J Salipante

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury   p525
Enrico Velardi, Jennifer J Tsai, Stefan Radtke, Kirsten Cooper, Kimon V Argyropoulos et al.

Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence   p525
James J Morrow, Ian Bayles, Alister P W Funnell, Tyler E Miller, Alina Saiakhova et al.

Corrigendum: Sex-specific transcriptional signatures in human depression   p525
Benoit Labonte, Olivia Engmann, Immanuel Purushothaman, Caroline Menard, Junshi Wang et al.

Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness   p525
Nicholas M Morton, Jasmina Beltram, Roderick N Carter, Zoi Michailidou, Gregor Gorjanc et al.

Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing   p526
Miguel Crespo, Eduardo Vilar, Su-Yi Tsai, Kyle Chang, Sadaf Amin et al.



Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions   p526
Hamid Bolouri, Jason E Farrar, Timothy Triche Jr, Rhonda E Ries, Emilia L Lim et al.

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells   p526
Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas et al.

Focal Point on Japan's Designated National University Initiative

Japan's radical new program to boost just a handful of universities has precedents across the world 

Access free online
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