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dinsdag 10 april 2018

Nature Medicine Contents: April 2018 Volume 24 Number 4 pp 375-526

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TABLE OF CONTENTS

April 2018 Volume 24, Issue 4

Editorial
News
News and Views
Review
Articles
Letters
Corrigenda
Errata
 
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Countering Antimicrobial Resistance

This conference will highlight work on understanding the ecology and spread of infectious agents and innovations in screening, therapeutic modalities and new countermeasures to address the spread of organisms resistant to carbapenem or vancomycin as well as multidrug-resistant Mycobacterium tuberculosis.

May 28-29, 2018 | Beijing, China

 
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Nature Milestone: Anticoagulants from Nature Reviews Cardiology 

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Nature Outlook: Bladder cancer 

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Editorial

Top

A checkup for the flu vaccine   p375
doi:10.1038/nm.4535
Influenza causes almost 650,000 deaths worldwide each year, yet a long-lasting, protective vaccine remains elusive. Global investment—both scientific and financial—in a universal flu vaccine is overdue.
 

News

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News Features

A tale of two diseases: Aging HIV patients inspire a closer look at Alzheimer's disease   pp376 - 377
Shraddha Chakradhar
doi:10.1038/nm0418-376
 

Experimenting with blockchain: Can one technology boost both data integrity and patients' pocketbooks?   pp378 - 381
Katharine Gammon
doi:10.1038/nm0418-378
 

News and Views

Top

A new site of attack for a malaria vaccine   pp382 - 383
Simon J Draper and Matthew K Higgins
doi:10.1038/nm.4533
A newly discovered antibody epitope on the liver-infective form of the parasite that causes malaria opens new doors for vaccine development.

See also: Article by Tan et al. | Article by Kisalu et al. |

Inflammation weakens HIV prevention   pp384 - 385
Thomas J Hope
doi:10.1038/nm.4534
The presence of multiple inflammatory cytokines predicts the failure of a topical 1% tenofovir microbicide gel to protect women against HIV infection.

See also: Article by McKinnon et al. |

Predicting leukemia relapse   pp385 - 387
Jose Ignacio Martin-Subero
doi:10.1038/nm.4529
Mass cytometry of acute B cell lymphoblastic leukemias at diagnosis reveals intrapatient phenotypic heterogeneity and specific signatures that mimic cell developmental stage and predict future relapse.

See also: Article by Good et al. |

Catalyzing the field of precision oncology, one basket at a time   pp387 - 388
William Pao and Imola Fodor
doi:10.1038/nm.4530
A bedside strategy to overcome the limitations of testing in preclinical models and to determine the role of gene mutations and their targetability directly in patients is presented.
 

Transplanted neural progenitors bridge gaps to benefit cord-injured monkeys   pp388 - 390
Steven A Goldman
doi:10.1038/nm.4531
Human neural progenitor cells have been grafted successfully into rhesus monkeys with spinal cord hemisection, resulting in anatomic integration and improved neurological function.

See also: Article by Rosenzweig et al. |

A molecular mechanism governing memory precision   pp390 - 391
Josue Haubrich and Karim Nader
doi:10.1038/nm.4532
A key molecular mechanism has been identified that dictates whether memory will maintain or lose its details over time and that is relevant in post-traumatic stress disorder and dementia.

See also: Article by Guo et al. |

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Review

Top

Current understanding of the human microbiome   pp392 - 400
Jack A Gilbert, Martin J Blaser, J Gregory Caporaso, Janet K Jansson, Susan V Lynch et al.
doi:10.1038/nm.4517
 

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Animation on CRISPR: Gene editing and beyond

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Articles

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A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein   pp401 - 407
Joshua Tan, Brandon K Sack, David Oyen, Isabelle Zenklusen, Luca Piccoli et al.
doi:10.1038/nm.4513
Volunteers who develop protection against malaria produce potent antibodies binding to a site of vulnerability on the parasite circumsporozoite protein that is absent in vaccines currently being tested in humans

See also: News and Views by Draper & Higgins | Article by Kisalu et al. |

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite   pp408 - 416
Neville K Kisalu, Azza H Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J Flynn et al.
doi:10.1038/nm.4512
The identification of antibodies targeting a conserved site of vulnerability in the Plasmodium falciparum circumsporozoite protein reveals opportunities for passive prevention of malaria in vulnerable individuals and provides insights for rational vaccine design.

See also: News and Views by Draper & Higgins | Article by Tan et al. |

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia   pp417 - 426
Pankaj Baral, Benjamin D Umans, Lu Li, Antonia Wallrapp, Meghna Bist et al.
doi:10.1038/nm.4501
Nociceptor sensory neurons suppress innate immunity during bacterial lung infection.
 

Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy   pp427 - 437
Nisha M Badders, Ane Korff, Helen C Miranda, Pradeep K Vuppala, Rebecca B Smith et al.
doi:10.1038/nm.4500
A preclinical therapy to treat neurodegeneration is developed that selectively targets the AF-2 domain of the androgen receptor while sparing other functions of this receptor.
 

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization   pp438 - 449
Nannan Guo, Marta E Soden, Charlotte Herber, Michael TaeWoo Kim, Antoine Besnard et al.
doi:10.1038/nm.4491
Dynamic regulation of the cytoskeletal factor ABLIM3 controls the precision of memory representations in rodent models of post-traumatic stress disorder and age-related cognitive impairment.

See also: News and Views by Haubrich & Nader |

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia   pp450 - 462
Bin Zhang, Le Xuan Truong Nguyen, Ling Li, Dandan Zhao, Bijender Kumar et al.
doi:10.1038/nm.4499
In chronic myelogenous leukemia, leukemia stem cell function requires a microRNA that is provided by bone marrow endothelial cells.
 

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling   pp463 - 473
Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen et al.
doi:10.1038/nm.4494
Paracrine signaling networks in the breast cancer microenvironment uncover determinants of hormone receptor status and offer opportunities for therapeutic intervention.
 

Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse   pp474 - 483
Zinaida Good, Jolanda Sarno, Astraea Jager, Nikolay Samusik, Nima Aghaeepour et al.
doi:10.1038/nm.4505
Mass cytometry of diagnostic biopsies from children with B cell precursor acute lymphoblastic leukemia identifies a signaling state that predicts relapse.

See also: News and Views by Martin-Subero |

Restorative effects of human neural stem cell grafts on the primate spinal cord   pp484 - 490
Ephron S Rosenzweig, John H Brock, Paul Lu, Hiromi Kumamaru, Ernesto A Salegio et al.
doi:10.1038/nm.4502
In a nonhuman primate model of spinal cord injury, human neural progenitor cell grafts exhibit long-term survival, differentiation, and anatomical integration with host spinal circuitry.

See also: News and Views by Goldman |

Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women   pp491 - 496
Lyle R McKinnon, Lenine J Liebenberg, Nonhlanhla Yende-Zuma, Derseree Archary, Sinaye Ngcapu et al.
doi:10.1038/nm.4506
In the absence of genital inflammation, tenofovir gel provides superior prevention against HIV acquisition in women.

See also: News and Views by Hope |

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Letters

Top

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers   pp497 - 504
Michael Seiler, Akihide Yoshimi, Rachel Darman, Betty Chan, Gregg Keaney et al.
doi:10.1038/nm.4493
The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding spliceosome components.
 

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer   pp505 - 511
Amritha Nair, Hsiang-Ching Chung, Tingting Sun, Siddhartha Tyagi, Lacey E Dobrolecki et al.
doi:10.1038/nm.4507
Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.
 

SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors   pp512 - 517
Leila Dardaei, Hui Qin Wang, Manrose Singh, Paul Fordjour, Katherine X Shaw et al.
doi:10.1038/nm.4497
Genomic and drug screens identify SHP2 blockade as a therapeutic approach for ALK-rearranged non-small cell lung cancers developing resistance through ALK-mutant-independent mechanisms.
 

Targeting hepatic glutaminase activity to ameliorate hyperglycemia   pp518 - 524
Russell A Miller, Yuji Shi, Wenyun Lu, David A Pirman, Aditi Jatkar et al.
doi:10.1038/nm.4514
In mice, elevated glucagon during type 2 diabetes promotes more hepatic glutamine flux and greater gluconeogenesis, while reducing glutamine metabolism in the liver lowers hyperglycemia.
 

Corrigenda

Top

Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types   p525
Ronald J Hause, Colin C Pritchard, Jay Shendure and Stephen J Salipante
doi:10.1038/nm0418-525a
 

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury   p525
Enrico Velardi, Jennifer J Tsai, Stefan Radtke, Kirsten Cooper, Kimon V Argyropoulos et al.
doi:10.1038/nm0418-525b
 

Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence   p525
James J Morrow, Ian Bayles, Alister P W Funnell, Tyler E Miller, Alina Saiakhova et al.
doi:10.1038/nm0418-525c
 

Corrigendum: Sex-specific transcriptional signatures in human depression   p525
Benoit Labonte, Olivia Engmann, Immanuel Purushothaman, Caroline Menard, Junshi Wang et al.
doi:10.1038/nm0418-525d
 

Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness   p525
Nicholas M Morton, Jasmina Beltram, Roderick N Carter, Zoi Michailidou, Gregor Gorjanc et al.
doi:10.1038/nm0418-525e
 

Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing   p526
Miguel Crespo, Eduardo Vilar, Su-Yi Tsai, Kyle Chang, Sadaf Amin et al.
doi:10.1038/nm0418-526a
 

Errata

Top

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions   p526
Hamid Bolouri, Jason E Farrar, Timothy Triche Jr, Rhonda E Ries, Emilia L Lim et al.
doi:10.1038/nm0418-526b
 

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells   p526
Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas et al.
doi:10.1038/nm0418-526c
 

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