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zaterdag 24 maart 2018

The Lancet: [Media Watch] Deadly delays and disparities

[Media Watch] Deadly delays and disparities
The HIV/AIDS epidemic changed our world. WHO estimates that 35 million people have died since it began in 1981, and another 36·7 million still live with the disease. We see its impact, too, in our response to it. An entirely new field—global health—emerged. The US Food and Drug Administration created a provisional accelerated approval pathway for potentially life-saving drugs to enter the market with preliminary evidence of efficacy. And societally, explicit and implicit tolerance of homophobia has rightly declined, although much work still needs to be done.
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[Corrections] Corrections
Flacco ME, Manzoli L, Rosso A, et al. Immunogenicity and safety of the multicomponent meningococcal B vaccine (4CMenB) in children and adolescents: a systematic review and meta-analysis. Lancet Infect Dis 2018; published online Jan 19. http://dx.doi.org/10.1016/S1473-3099(18)30048-3—In this Article, the author name 'Mario Bergamini' should read 'Mauro Bergamini'. In the seventh paragraph of the Results, 'M110713' should read 'M10713'. In the fifth paragraph of the Discussion, the sentence 'whereas in the UK only two doses and a booster dose are recommended for all infants and children after age 5 months.
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[Series] Tuberculosis: advances and challenges in development of new diagnostics and biomarkers
Tuberculosis remains the leading cause of death from an infectious disease worldwide. Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis is essential for achieving global tuberculosis control. Despite the introduction of the Xpert MTB/RIF assay as the first-line rapid tuberculosis diagnostic test, the gap between global estimates of incidence and new case notifications is 4·1 million people. More accurate, rapid, and cost-effective screening tests are needed to improve case detection.
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[Comment] Concrete action now: UN High-Level Meeting on Tuberculosis
World Tuberculosis Day, March 24, 2018, will mark 136 years since the discovery of Mycobacterium tuberculosis by Robert Koch.1 Having been declared a global health emergency a quarter of a century ago,2 the Sustainable Development Goals3 and the WHO End TB Strategy4 envision ending the tuberculosis pandemic by 2030. Today, tuberculosis remains the leading cause of death from an infectious disease and the ninth leading cause of death worldwide.5 In 2016, an estimated 10·4 million people developed tuberculosis and 1·67 million people died as a result of the disease, exceeding the combined number of deaths from HIV and malaria during the same period.
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[Series] Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies
Tuberculosis remains the world's leading cause of death from an infectious disease, responsible for an estimated 1 674 000 deaths annually. WHO estimated 600 000 cases of rifampicin-resistant tuberculosis in 2016—of which 490 000 were multidrug resistant (MDR), with less than 50% survival after receiving recommended treatment regimens. Concerted efforts of stakeholders, advocates, and researchers are advancing further development of shorter course, more effective, safer, and better tolerated treatment regimens.
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