We bring you the latest news from the healthcare about the health care in the United Kingdom.

maandag 26 maart 2018

The Lancet: [Correspondence] Accelerated long-term forgetting in asymptomatic APOE ε4 carriers

[Correspondence] Accelerated long-term forgetting in asymptomatic APOE ε4 carriers
In The Lancet Neurology, Philip Weston and colleagues report that presymptomatic individuals carrying familial Alzheimer's disease gene mutations demonstrate accelerated long-term forgetting over an extended 1 week retention interval compared with gene-negative controls.1 These findings raise the question of whether accelerated long-term forgetting is also detectable in presymptomatic individuals at genetic risk of the much more common sporadic form of Alzheimer's disease.
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[In Context] Frederik Barkhof: building bridges between disciplines
The early academic journey of Frederik Barkhof was a winding one. As a child he was fascinated by the engineering of buildings and bridges, but then crossed over to study dentistry—"which was a mistake" (a bridge too far, presumably). He next stopped to study at the intersection between philosophy and medicine, until he landed at VU University (Amsterdam, the Netherlands) where he received his MD in 1988. Combining his love of engineering and medicine, Barkhof is now a neuroradiology professor who shares his expertise with both VU University Medical Centre and University College London (UCL, London, UK) and brings decades of experience and knowledge, particularly in MRI techniques, to translating novel imaging techniques from engineering technology to clinical applications.
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[Corrections] Corrections
Grisold W, Wasay M. The advocacy role of the World Federation of Neurology. Lancet Neurol 2018; 17: 204—The name of the second author, Mohammad Wasay, was written incorrectly. This name has been corrected in the online version as of March 22, 2018.
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[In Context] How far away the cornfield. Dennis Spencer's journey
Bedford, Iowa. Small-town stuff among the unending corn and wheat; fields separated by dirt tracks on a grid system. The wind blows here; nothing to stop it except for a few lines of trees here and there, waiting for the next tornado. But with a circular horizon comes a big sky, and everyone gets to see the sun go the whole 180, full east to full west. Folks farm here mostly, or do things wrapped up with the land in one way or another. They don't usually become professors of neurosurgery at Yale.
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[Comment] What if you knew the prognosis of your patients with ALS?
More than 60 years ago, Karl Jaspers1 stated that when patients plead for the truth, most of them just want assurance. Forbes Norris, one of the most respected American experts on amyotrophic lateral sclerosis (ALS), used to tell his patients: "I think you have ALS, but I might be wrong". His intention was to try to convey some uncertainty regarding the diagnosis, which could provide hope for some patients. After so many years, have we made any progress in relaying diagnoses and prognoses to patients with ALS? In The Lancet Neurology, a research team led by Leonard van den Berg and colleagues now reports on a comprehensive model developed to provide estimates of prognosis for individual patients with ALS.
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