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woensdag 7 maart 2018

The Lancet: [Comment] FGF-19 agonism for NASH: a short study of a long disease

[Comment] FGF-19 agonism for NASH: a short study of a long disease
Non-alcoholic steatohepatitis (NASH) has emerged as the most common cause of liver disease worldwide and is on a trajectory to become the most common indication for liver transplantation.1,2 Interest in developing effective therapies for NASH has been proportional. Since its original scientific description, NASH has been a histologically defined disease, characterised by hepatic steatosis and inflammation with variable presence and severity of Mallory's hyaline, balloon degeneration, and, most important clinically, fibrosis.
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[Articles] NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
NGM282 produced rapid and significant reductions in liver fat content with an acceptable safety profile in patients with non-alcoholic steatohepatitis. Further study of NGM282 is warranted in this patient population.
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[Seminar] Migraine
Migraine is a chronic paroxysmal neurological disorder characterised by multiphase attacks of head pain and a myriad of neurological symptoms. The underlying genetic and biological underpinnings and neural networks involved are coming sharply into focus. This progress in the fundamental understanding of migraine has led to novel, mechanism-based and disease-specific therapeutics. In this Seminar, the clinical features and neurobiology of migraine are reviewed, evidence to support available treatment options is provided, and emerging drug, device, and biological therapies are discussed.
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[Correspondence] Female physicians nominated for the Nobel Prize 1901–50
Recent contributions in The Lancet have discussed the under-representation of women at senior levels in medicine and the life sciences.1 This trend mirrors the gender gap in the number of Nobel Prize nominees and laureates in physiology or medicine. Drawing on sources from the archive of the Nobel committee in Sweden, we have found that the lion's share of both nominators and nominees were men during the first half of the 20th century (archival material for the last 50 years is not yet available).
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[Comment] Report card shows gender is missing in global health
Gender equality benefits everyone—from contributing more representative and effective organisations, to ensuring better health outcomes. Yet, even in 2018, it remains remarkably hard to achieve. The World Economic Forum's Global Gender Gap Report 20171 estimates that it will now take 217 years to close the global workplace gender gap; indeed, the gap widened last year for the first time since the report was launched in 2006.
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