We bring you the latest news from the healthcare about the health care in the United Kingdom.

donderdag 1 maart 2018

The Lancet: [Comment] Evidence to improve the treatment of infections caused by carbapenem-resistant Gram-negative ba...

[Comment] Evidence to improve the treatment of infections caused by carbapenem-resistant Gram-negative bacteria
WHO recognises carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Entero-bacteriaceae as pathogens of crucial importance for the development of novel antibiotics.1 These bacteria manifest resistance to our most trusted therapeutics and, as a result of their increasing prevalence and transmissibility, are becoming an overwhelming health-care burden.2 Over the past decade, polymyxins (an old class of cationic antimicrobial peptide antibiotics) became the drugs of last resort to treat carbapenem-resistant Gram-negative bacteria.
Read more

[Personal View] The eyes have it: influenza virus infection beyond the respiratory tract
Avian and human influenza A viruses alike have shown a capacity to use the eye as a portal of entry and cause ocular disease in human beings. However, whereas influenza viruses generally represent a respiratory pathogen and only occasionally cause ocular complications, the H7 virus subtype stands alone in possessing an ocular tropism. Clarifying what confers such non-respiratory tropism to a respiratory virus will permit a greater ability to identify, treat, and prevent zoonotic human infection following ocular exposure to influenza viruses; especially those within the H7 subtype, which continue to cause avian epidemics on many continents.
Read more

[Corrections] Corrections
Dorman SE, Schumacher SG, Alland D, et al. Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect Dis 2018; 18: 76–84. This Open Access Article is now under the CC BY 4.0 license. This correction has been made to the online version as of Feb 21, 2018.
Read more

[Personal View] Enterovirus D68 and acute flaccid myelitis—evaluating the evidence for causality
Increased circulation of enterovirus D68 in 2014 and 2016 temporally and geographically coincided with increases in cases of acute flaccid myelitis, an uncommon condition of paralysis due to lesions in the anterior horn of the spinal cord. The identification of enterovirus D68 in respiratory specimens from cases of acute flaccid myelitis worldwide further supports an association, yet the absence of direct virus isolation from affected tissues, infrequent detection in cerebrospinal fluid, and the absence, until recently, of an animal model has left the causal nature of the relationship unproven.
Read more

[Corrections] Corrections
Tängdén T, Pulcini C, Aagaard H, et al. Unavailability of old antibiotics threatens effective treatment for common bacterial infections. Lancet Infect Dis 2018; 18: 242–44—In the author byline of this Comment on page 243, the third coauthor's name was misspelt and should read "Helle Aagaard". This correction has been made to the online version as of Feb 28, 2018.
Read more