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The EMBO Journal Table of Contents for 01 March 2018; Vol. 37, No. 5

01 March 2018 | Volume 37, Number 5 Submit


Table of Contents

Articles
News & Views
COVER

Volume 37, Number 5



Articles
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Identification of an internal ribosome entry site in the mRNA of the actin regulator cofilin implicates cap‐independent translation in axonal growth and neuronal development.

Jung‐Hyun Choi, Wei Wang, Dongkeun Park, Sung‐Hoon Kim, Kyong‐Tai Kim and Kyung‐Tai Min
Published online 12.02.2018

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Interaction with β‐actin activates SHP‐1 phosphatase at the inhibitory immunological synapse to suppress natural killer cell cytotoxicity.

Omri Matalon, Aviad Ben‐Shmuel, Jessica Kivelevitz, Batel Sabag, Sophia Fried, Noah Joseph, Elad Noy, Guy Biber and Mira Barda‐Saad
Published online 15.02.2018

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A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation and RNA splicing. Structural and functional analyses of ALS‐related protein TDP43 illustrates its higher order organisation and links splicing activity with the ability to undergo liquid‐liquid phase separation.

Ailin Wang, Alexander E Conicella, Hermann Broder Schmidt, Erik W Martin, Shannon N Rhoads, Ashley N Reeb, Amanda Nourse, Daniel Ramirez Montero, Veronica H Ryan, Rajat Rohatgi, Frank Shewmaker, Mandar T Naik, Tanja Mittag, Yuna M Ayala and Nicolas L Fawzi
Published online 09.02.2018 Open Access

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Presentation of gut microbial and self lipids to natural killer T cells is key to maintaining intestinal microbiota composition and immune cell populations.

Julia Sáez de Guinoa, Rebeca Jimeno, Mauro Gaya, David Kipling, María José Garzón, Deborah Dunn‐Walters, Carles Ubeda and Patricia Barral
Published online 29.01.2018 Open Access

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α‐Melanocyte‐stimulating hormone induces interaction of calcium sensor STIM1 with ADCY6 at endoplasmic reticulum–plasma membrane junctions to increase cAMP synthesis and promote pigmentation.

Rajender K Motiani, Jyoti Tanwar, Desingu Ayyappa Raja, Ayushi Vashisht, Shivangi Khanna, Sachin Sharma, Sonali Srivastava, Sridhar Sivasubbu, Vivek T Natarajan and Rajesh S Gokhale
Published online 08.01.2018

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Melanoma cells with high c‐Myc levels are aggressive, have tumor initiation potential and engage the metabolic checkpoint kinase AMPK to counterbalance Myc‐induced stress in energy and redox homeostasis.

Alain Kfoury, Marzia Armaro, Caterina Collodet, Jessica Sordet‐Dessimoz, Maria Pilar Giner, Stefan Christen, Sofia Moco, Marion Leleu, Laurence de Leval, Ute Koch, Andreas Trumpp, Kei Sakamoto, Friedrich Beermann and Freddy Radtke
Published online 12.02.2018

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A novel Chk1‐dependent E2F7/8‐inactivating pathway that sustains S phase gene expression upon DNA damage may also contribute to deregulated E2F target gene expression in human cancer.

Ruixue Yuan, Harmjan R Vos, Robert M van Es, Jing Chen, Boudewijn MT Burgering, Bart Westendorp and Alain de Bruin
Published online 23.01.2018 Open Access

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In a reconstituted system, the selective autophagy cargo receptor p62 and ubiquitinated substrates spontaneously coalesce into larger clusters due to crosslinking of p62 filaments by the substrates.

Gabriele Zaffagnini, Adriana Savova, Alberto Danieli, Julia Romanov, Shirley Tremel, Michael Ebner, Thomas Peterbauer, Martin Sztacho, Riccardo Trapannone, Abul K Tarafder, Carsten Sachse and Sascha Martens
Published online 17.01.2018 Open Access

News & Views
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New results link an ER calcium sensor to cAMP synthesis in the physiological context of melanin production.

Jonathan Soboloff, Bojana Gligorijevic and M Raza Zaidi
Published online 15.02.2018

 
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