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dinsdag 6 maart 2018

Nature Structural & Molecular Biology Contents: 2018 Volume #25 pp 195 - 296

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Nature Structural & Molecular Biology

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March 2018 Volume 25, Issue 3

News & Views
Technical Reports
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RNA at the Bench & Bedside October 8-10, La Jolla, USA

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News & Views


Turning the table on miRNAs    pp195 - 197
Manuel de la Mata & Helge Großhans

Rewriting the past: de novo activity of PRC2 restores global H3K27 methylation patterns    pp197 - 199
Jafar Sharif & Haruhiko Koseki

Speed up to find the right ones: rapid discovery of functional nanobodies    pp199 - 201
Ulrich Rothbauer

TAp63 as a guardian of female germ line integrity    pp201 - 202
Wa Xian & Frank McKeon

Structural & Molecular Biology
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Animation on CRISPR: Gene editing and beyond

The CRISPR-Cas9 system has revolutionised gene editing, but cutting DNA isn't all it can do.

This Animation, from Nature Methods, explores where CRISPR might be headed next. 

Watch the Animation >> 

Produced with support from: 



Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility    pp203 - 207
Danielle A. Grotjahn, Saikat Chowdhury, Yiru Xu, Richard J. McKenney, Trina A. Schroer et al.

Cryo-ET analyses of the microtubule-bound mouse dynein-dynactin complex reveal two dimeric dyneins interacting with the dynactin-cargo adaptor complex, a configuration that can account for processivity and directionality of dynein transport activity.


2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation    pp208 - 216
Junhong Choi, Gabriele Indrisiunaite, Hasan DeMirci, Ka-Weng Ieong, Jinfan Wang et al.

2′-O-methylation within mRNA coding regions sterically perturbs interactions of ribosomal-monitoring bases with cognate codon-anticodon helices, leading to excessive rejection of cognate aminoacylated tRNAs during initial selection and proofreading.


GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation    pp217 - 224
Jiho Yoo, Ellene H. Mashalidis, Alvin C. Y. Kuk, Kazuki Yamamoto, Benjamin Kaeser et al.

Crystal structures of human GPT in complex with tunicamycin provide insight into mechanisms of inhibition and differences between human and bacterial enzymes, leading to the design of an analog with specificity for the bacterial enzyme.


Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2    pp225 - 232
Jonas W. Højfeldt, Anne Laugesen, Berthe M. Willumsen, Helene Damhofer, Lin Hedehus et al.

Although mechanisms wherein pre-existing H3K27 methylation directs recruitment of PRC2 to support its own maintenance have been proposed, H3K27 methylation patterns in mESCs are not dependent on self-autonomous epigenetic inheritance.


Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion    pp233 - 243
Liming Yan, Yuanbo Qi, Xiaofang Huang, Caiting Yu, Lan Lan et al.

The structure of the minimal GTPase domain of human MFN1 reveals a new, closed conformation and suggests how mitofusin pulls membranes closer to facilitate fusion and how MFN2 mutations impair mitochondria in Charcot-Marie-Tooth neuropathy type 2A.


MicroRNA degradation by a conserved target RNA regulates animal behavior    pp244 - 251
Angelo Bitetti, Allison C. Mallory, Elisabetta Golini, Claudia Carrieri, Héctor Carreño Gutiérrez et al.

RNA-directed miRNA degradation triggered by a brain-specific genome-encoded transcript regulates explorative and anxiety-like behavior in zebrafish and affects balance and motor learning in mice.


Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms    pp252 - 260
Zengqin Deng, Navid Paknejad, Grigory Maksaev, Monica Sala-Rabanal, Colin G. Nichols et al.

Structural analyses of Xenopus tropicalis TRPV4 reveal a single ion-binding site in the selectivity filter and distinct interactions between the voltage-sensor-like and pore domains and provide a blueprint to understanding disease-related mutations.


Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63    pp261 - 269
Marcel Tuppi, Sebastian Kehrloesser, Daniel W. Coutandin, Valerio Rossi, Laura M. Luh et al.

p63 activation in response to DNA damage leads to oocyte death and loss of fertility in women receiving chemotherapy. Activation requires sequential phosphorylation by CHK2 and CK1 kinases, and inhibition of these kinases rescues oocytes from apoptosis induced by chemotherapy.


Screening, large-scale production and structure-based classification of cystine-dense peptides    pp270 - 278
Colin E. Correnti, Mesfin M. Gewe, Christopher Mehlin, Ashok D. Bandaranayake, William A. Johnsen et al.

A platform for high-throughput expression screening and large-scale production of cystine-dense peptides, alongside a global structure-based classification, is presented.


Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins    pp279 - 288
Eviatar Natan, Tamaki Endoh, Liora Haim-Vilmovsky, Tilman Flock, Guilhem Chalancon et al.

In vivo, in vitro and in silico experiments demonstrate that interface residues of homomeric proteins are enriched toward protein C termini to avoid premature assembly and aggregation.


Technical Reports


Yeast surface display platform for rapid discovery of conformationally selective nanobodies    pp289 - 296
Conor McMahon, Alexander S. Baier, Roberta Pascolutti, Marcin Wegrecki, Sanduo Zheng et al.

Yeast surface display platform allows nanobody discovery within two to three weeks. Examples include nanobodies for crystallographic applications, targeting nonpurified antigen or conformationally selective nanobodies to two distinct human GPCRs.


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