We bring you the latest news from the healthcare about the health care in the United Kingdom.

maandag 12 maart 2018

Nature Reviews Microbiology contents April 2018 Volume 16 Number 4 pp 183-255

Nature Reviews Microbiology

April 2018 Volume 16 Number 4
Nature Reviews Microbiology cover
2016 2-year Impact Factor 26.819 Journal Metrics 2-year Median 18
In this issue
News and Analysis
Research Highlights
Also this month
Article series:
New technologies: methods and applications
 Featured article:
Prokaryotic cytoskeletons: protein filaments organizing small cells
James Wagstaff & Jan Löwe


Recommend to library
Nature Collection: Gut-brain axis 

This Nature Collection brings together Research, Reviews and News from across the Nature Research journals and presents a selection of articles covering key aspects of the gut-brain axis including the gut microbiota and immune, neuroendocrine and neural factors. 

Access this collection >> 

Produced with support from: 

Cellular microbiology: Lysozyme protects bacteria from β-lactams
p183 | doi:10.1038/nrmicro.2018.26
A recent study reports that host lysozyme counteracts β-lactam-mediated killing of some bacteria by promoting efficient L-form switching.


Bacterial pathogenesis: Channelling the host epigenome
p184 | doi:10.1038/nrmicro.2018.25
This study reports that the P. aeruginosa type III secretion system translocon functions as a pore-forming toxin that triggers the modification of histones in eukaryotic cells.


Bacterial physiology: Bridging the gap for lipopolysaccharides
p184 | doi:10.1038/nrmicro.2018.30
This study provides evidence that lipopolysaccharides are pushed from the inner membrane to the outer membrane of the bacterial cell envelope over a protein bridge.


Resurrection of a poxvirus causes alarm

p184 | doi:10.1038/nrmicro.2018.31
A controversial study in which researchers generated an infectious horsepox virus using synthetic DNA and reverse genetics was recently reported.



A new piece in the microbiome puzzle
Lindsay J. Pike & Samuel C. Forster

p186 | doi:10.1038/nrmicro.2018.24
This month's Genome Watch discusses the detailed analysis of the human 'archaeome' from various body sites and highlights how current sequencing methods underestimate archaeal diversity and abundance.



Antimicrobials: Breaking ground for new antibiotics | Viral infection: CRISPR–Cas enhances HGT by transduction | Microbiome: Principles of microbiota engraftment

Poster on: The expanding CRISPR toolbox

The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR. 

Available to download free online >> 

Produced with support from: 
Prokaryotic cytoskeletons: protein filaments organizing small cells
James Wagstaff & Jan Löwe

p187 | doi:10.1038/nrmicro.2017.153
Bacteria and archaea have intracellular cytoskeletons built from dynamic protein filaments. In this Review, Wagstaff and Lowe discuss how these linear protein polymers are used to organize other molecules in prokaryotic cells.
Abstract | Full Text | PDF

Ecology and evolution of Mycobacterium tuberculosis
Sebastien Gagneux

p202 | doi:10.1038/nrmicro.2018.8
The causative agents of tuberculosis are a group of closely related bacteria known as the Mycobacterium tuberculosis complex (MTBC). In this Review, Gagneux discusses recent insights into the origin of the MTBC, its molecular evolution and population genetic characteristics, and the evolution of antibiotic resistance.
Abstract | Full Text | PDF

Article series: New technologies: methods and applications
Engineering bacteria for diagnostic and therapeutic applications
David T. Riglar & Pamela A. Silver

p214 | doi:10.1038/nrmicro.2017.172
Advances in synthetic biology allow the generation of ever more sophisticated engineered bacteria. In this Review, Riglar and Silver showcase recent highlights in engineered bacterial therapeutics and diagnostics and discuss how best to develop them for clinical application.
Abstract | Full Text | PDF | Supplementary information

Neisseria gonorrhoeae host adaptation and pathogenesis
Sarah Jane Quillin & H Steven Seifert

p226 | doi:10.1038/nrmicro.2017.169
The host-adapted human pathogen Neisseria gonorrhoeae is the causative agent of gonorrhoea. In this Review, Quillin and Seifert provide an overview of the bacterial factors that are important for the different stages of pathogenesis, including transmission, colonization and immune evasion, and discuss the problem of antibiotic resistance.
Abstract | Full Text | PDF

The spread and evolution of rabies virus: conquering new frontiers
Christine R. Fisher, Daniel G. Streicker & Matthias J. Schnell

p241 | doi:10.1038/nrmicro.2018.11
Much of the molecular virology of rabies virus has been well characterized, and we are gaining a better understanding of how infection dynamics and immune status relate to transmission. In this Review, Schnell and colleagues explore rabies virus transmission, enzootic maintenance and epizootic spread, as well as molecular evolutionary dynamics, host adaptation and the origins of rabies virus.
Abstract | Full Text | PDF

Do you have a career question?

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today! 
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.

Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events


You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature