We bring you the latest news from the healthcare about the health care in the United Kingdom.

maandag 26 maart 2018

Nature Reviews Immunology Contents April 2018 Volume 18 Number 4 pp 221-287

If you are unable to see the message below, click here to view.
Nature Reviews Immunology

New Infographic: CD47 regulation of cellular phagocytosis in cancer, inflammation & neurobiology 
April 2018 Volume 18 Number 4
Nature Reviews Immunology cover
2016 2-year Impact Factor 39.932 Journal Metrics 2-year Median 29
In this issue
Research Highlights
Also this month
 Featured article:
Microglia and macrophages in brain homeostasis and disease
Qingyun Li & Ben A. Barres


Recommend to library
Key Advances in Medicine eBook from Nature Reviews ? FREE to download!

This essential resource summarizes the ground-breaking clinical and biomedical discoveries of 2017 and highlights the trends to watch out for in 2018, making it a must read eBook for anyone with an interest in medical science.

Download for free.

Immunotherapy: Tear down this wall
p221 | doi:10.1038/nri.2018.20
Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response.

Antibodies: Septic shock absorbers
p222 | doi:10.1038/nri.2018.17
Gut commensals induce systemic IgA responses that protect mice against lethal sepsis.

Neuroimmunology: No pain, all gain
p222 | doi:10.1038/nri.2018.21
Sensory neurons in the lungs suppress immune responses to bacterial lung infections.

Vaccines: Stem cell hope for cancer treatment
p223 | doi:10.1038/nri.2018.16
An irradiated induced pluripotent stem cell-based vaccine induces cancer immunity in vivo.

Stem cells: Escape from the Jedi
p224 | doi:10.1038/nri.2018.18
Quiescent adult stem cells escape immune surveillance by downregulating the antigen presentation machinery.

A novel genetic architecture of infectious diseases

p224 | doi:10.1038/nri.2018.19
Laurent Abel describes two landmark studies from 1996 that described the genetic susceptibility of children to severe mycobacterial infections.


Nature Reviews Immunology
JOBS of the week
Malaria Pathogenesis and Immunity Postdoctoral Scientist
National Institute of Allergy and Infectious Diseases
Executive Director, Brown Center for Immunotherapy
Indiana University School of Medicine
University Professor of Immunogerontology
University of Innsbruck
Postdoctoral Position - Immune Oncology
H. Lee Moffitt Cancer & Research Institute
Scientist I / II, Immunology
More Science jobs from
Nature Reviews Immunology
Nutritional Immunology and the Microbiota: Rules of Engagement in Health and Disease
Leesburg, USA
More science events from
Nature Outlook: The future of medicine 

Modern medicine is affording people longer and healthier lives. But researchers want to take improvements in health even further. With advances in gene editing, technology to overcome paralysis and efforts to address high drug costs, the future of medicine is bright.

Get your free access 

Produced with support from Merck
Microglia and macrophages in brain homeostasis and disease
Qingyun Li & Ben A. Barres

p225 | doi:10.1038/nri.2017.125
This Review describes recent advances in our understanding of the ontogeny, development and function of brain-resident macrophages and microglia, including their normal functions during brain development and homeostasis and how disturbance of these functions may precipitate neurodegenerative and neuropsychiatric diseases.
Abstract | Full Text | PDF

Peptidoglycan recognition by the innate immune system
Andrea J. Wolf & David M. Underhill

p243 | doi:10.1038/nri.2017.136
Peptidoglycan is an important structural component of bacterial cell walls, and mammalian cells express a number of distinct pattern-recognition receptors that detect peptidoglycan fragments. Here, the authors discuss new insights into the role of peptidoglycan recognition in inflammation, metabolism and disease.
Abstract | Full Text | PDF

Viral subversion of B cell responses within secondary lymphoid organs
Mirela Kuka & Matteo Iannacone

p255 | doi:10.1038/nri.2017.133
The development of multiphoton intravital microscopy has enabled detailed studies of humoral responses within lymphoid tissues. Here, Kuka and Iannacone cover recent studies of the viral subversion of B cell responses and discuss how these findings relate to our understanding of B cell activation within secondary lymphoid organs.
Abstract | Full Text | PDF

Tissue-specific immunopathology during malaria infection
Cevayir Coban, Michelle Sue Jann Lee & Ken J. Ishii

p266 | doi:10.1038/nri.2017.138
Although systemic infection is a hallmark of malaria disease, less is known regarding how parasitized erythrocytes interact locally with host tissues. In this Review, the authors discuss how infected erythrocytes reach different tissue environments and cause specific pathological consequences in malaria.
Abstract | Full Text | PDF

nature.com webcasts

Nature Research Custom presents a webcast on: Accelerating the Discovery of New Antimicrobial Compounds

Date: Thursday, April 26, 2018

This webcast has been produced on behalf of the sponsor who retains sole responsibility for content 

Register for FREE 

Sponsored by: Labcyte 
How poverty affects diet to shape the microbiota and chronic disease
Christy A. Harrison & Douglas Taren

p279 | doi:10.1038/nri.2017.121
In this Opinion article, the authors consider how poverty and diet can shape the microbiota and immune health. They highlight how this contributes to the greater levels of chronic disease that are experienced by low-income individuals in high-income societies.
Abstract | Full Text | PDF

nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.

Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature