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maandag 26 maart 2018

Nature Reviews Immunology Contents April 2018 Volume 18 Number 4 pp 221-287

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Nature Reviews Immunology
 

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TABLE OF CONTENTS
 
April 2018 Volume 18 Number 4
Nature Reviews Immunology cover
2016 2-year Impact Factor 39.932 Journal Metrics 2-year Median 29
In this issue
Research Highlights
Reviews
Perspectives
 
Also this month
 Featured article:
Microglia and macrophages in brain homeostasis and disease
Qingyun Li & Ben A. Barres

 
 

 
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RESEARCH HIGHLIGHTS
 
Top

Immunotherapy: Tear down this wall
p221 | doi:10.1038/nri.2018.20
Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response.
PDF


Antibodies: Septic shock absorbers
p222 | doi:10.1038/nri.2018.17
Gut commensals induce systemic IgA responses that protect mice against lethal sepsis.
PDF


Neuroimmunology: No pain, all gain
p222 | doi:10.1038/nri.2018.21
Sensory neurons in the lungs suppress immune responses to bacterial lung infections.
PDF


Vaccines: Stem cell hope for cancer treatment
p223 | doi:10.1038/nri.2018.16
An irradiated induced pluripotent stem cell-based vaccine induces cancer immunity in vivo.
PDF


Stem cells: Escape from the Jedi
p224 | doi:10.1038/nri.2018.18
Quiescent adult stem cells escape immune surveillance by downregulating the antigen presentation machinery.
PDF


JOURNAL CLUB
A novel genetic architecture of infectious diseases

p224 | doi:10.1038/nri.2018.19
Laurent Abel describes two landmark studies from 1996 that described the genetic susceptibility of children to severe mycobacterial infections.
PDF


 

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REVIEWS
 
Top
Microglia and macrophages in brain homeostasis and disease
Qingyun Li & Ben A. Barres

p225 | doi:10.1038/nri.2017.125
This Review describes recent advances in our understanding of the ontogeny, development and function of brain-resident macrophages and microglia, including their normal functions during brain development and homeostasis and how disturbance of these functions may precipitate neurodegenerative and neuropsychiatric diseases.
Abstract | Full Text | PDF

 
Peptidoglycan recognition by the innate immune system
Andrea J. Wolf & David M. Underhill

p243 | doi:10.1038/nri.2017.136
Peptidoglycan is an important structural component of bacterial cell walls, and mammalian cells express a number of distinct pattern-recognition receptors that detect peptidoglycan fragments. Here, the authors discuss new insights into the role of peptidoglycan recognition in inflammation, metabolism and disease.
Abstract | Full Text | PDF

 
Viral subversion of B cell responses within secondary lymphoid organs
Mirela Kuka & Matteo Iannacone

p255 | doi:10.1038/nri.2017.133
The development of multiphoton intravital microscopy has enabled detailed studies of humoral responses within lymphoid tissues. Here, Kuka and Iannacone cover recent studies of the viral subversion of B cell responses and discuss how these findings relate to our understanding of B cell activation within secondary lymphoid organs.
Abstract | Full Text | PDF

 
Tissue-specific immunopathology during malaria infection
Cevayir Coban, Michelle Sue Jann Lee & Ken J. Ishii

p266 | doi:10.1038/nri.2017.138
Although systemic infection is a hallmark of malaria disease, less is known regarding how parasitized erythrocytes interact locally with host tissues. In this Review, the authors discuss how infected erythrocytes reach different tissue environments and cause specific pathological consequences in malaria.
Abstract | Full Text | PDF

 
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PERSPECTIVES
 
Top
OPINION
How poverty affects diet to shape the microbiota and chronic disease
Christy A. Harrison & Douglas Taren

p279 | doi:10.1038/nri.2017.121
In this Opinion article, the authors consider how poverty and diet can shape the microbiota and immune health. They highlight how this contributes to the greater levels of chronic disease that are experienced by low-income individuals in high-income societies.
Abstract | Full Text | PDF

 
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