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Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 15 Issue 4

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Nature Reviews Gastroenterology & Hepatology

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April 2018 Volume 15 Number 4
Nature Reviews Gastroenterology & Hepatology cover
2016 2-year Impact Factor 13.678 Journal Metrics 2-year Median 8
In this issue
Research Highlights
News and Views
Also this month
 Featured article:
Role of priority effects in the early-life assembly of the gut microbiota
Daniel Sprockett, Tadashi Fukami & David A. Relman


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Nature Collection: Gut-brain axis 

This Nature Collection brings together Research, Reviews and News from across the Nature Research journals and presents a selection of articles covering key aspects of the gut-brain axis including the gut microbiota and immune, neuroendocrine and neural factors. 

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Gastrointestinal cancer: Organoids predict clinical responses
Published online: 14 March 2018
p189 | doi:10.1038/nrgastro.2018.25


IBD: Functional characterization of an IBD risk gene
Published online: 21 February 2018
p190 | doi:10.1038/nrgastro.2018.17


Therapy: FMT: the rules of engraftment
Published online: 28 February 2018
p190 | doi:10.1038/nrgastro.2018.19


Colorectal cancer: Evading the immune response in metastasis
Published online: 28 February 2018
p191 | doi:10.1038/nrgastro.2018.18




Liver cancer: Lenvatinib non-inferior to sorafenib for hepatocellular carcinoma | Viral hepatitis: A new model for HBV infection of primary human hepatocytes | Surgery: Describing the global burden of infection after gastrointestinal surgery

Nature Reviews Gastroenterology & Hepatology
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Gut microbiota: Beyond metagenomics, metatranscriptomics illuminates microbiome functionality in IBD
Aonghus Lavelle & Harry Sokol

Published online: 21 February 2018
p193 | doi:10.1038/nrgastro.2018.15

Although metagenomic sequencing has provided unprecedented characterization of the gut microbiome, it gives only indirect evidence of the genes and pathways that might be active. Now, investigators have combined longitudinal sampling with metatranscriptomics and metagenomics in IBD to provide a high-resolution picture of the microbiome's functional dynamics.
Full Text | PDF

Hepatitis: No cure for hepatitis B and D without targeting integrated viral DNA?
Markus Cornberg & Michael P. Manns

Published online: 31 January 2018
p195 | doi:10.1038/nrgastro.2017.185

RNA interference (RNAi) is a novel concept to target transcripts derived from HBV covalently closed circular DNA. The study by Wooddell et al. investigates the RNAi-based therapy ARC-520 in patients and chimpanzees with chronic HBV infection and uncovers HBV DNA integration as a crucial source of hepatitis B surface antigen, which has not been considered in current strategies to accomplish HBV cure.
Full Text | PDF

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis: a role for bifidobacteria and lactobacilli?
Borja Sanchez

Published online: 07 March 2018
p205 | doi:10.1038/nrgastro.2018.23

Full Text | PDF
Probiotics, bile acids and gastrointestinal carcinogenesis
Wei Jia & Guoxiang Xie

Published online: 07 March 2018
p205 | doi:10.1038/nrgastro.2018.24

Full Text | PDF
Role of priority effects in the early-life assembly of the gut microbiota
Daniel Sprockett, Tadashi Fukami & David A. Relman

Published online: 24 January 2018
p197 | doi:10.1038/nrgastro.2017.173

The human gut microbiota undergoes dramatic development early in life. Here, the authors explore how this development is influenced by priority effects, whereby the order and timing of microbial species arrival affect community assembly. In turn, factors affecting order and timing, including delivery mode, diet and parenting behaviours, are also discussed.
Abstract | Full Text | PDF

Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system
Masaki Honda & Paul Kubes

Published online: 31 January 2018
p206 | doi:10.1038/nrgastro.2017.183

Neutrophil extracellular traps (NETs) have an important role during infection but they are also related to the exacerbation of inflammation and the development of autoimmunity, cancer metastasis and inappropriate thrombosis. Here, the authors focus on the role of NETs in the liver and gastrointestinal system, outlining their protective and pathological effects and their potential for therapeutic intervention.
Abstract | Full Text | PDF

Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management
Mark A. Samaan et al.

Published online: 07 March 2018
p222 | doi:10.1038/nrgastro.2018.14

Immune checkpoint inhibitors are a novel approach to cancer immunotherapy. However, they are associated with substantial risk of immune-related adverse events, including gastrointestinal toxicity. This Review explores the manifestations of gastrointestinal toxicity with immune checkpoint inhibitor use and insights into its management.
Abstract | Full Text | PDF

Treatment for unresectable or metastatic oesophageal cancer: current evidence and trends
Peter S. N. van Rossum, Nadia Haj Mohammad, Frank P. Vleggaar & Richard van Hillegersberg

Published online: 13 December 2017
p235 | doi:10.1038/nrgastro.2017.162

Approximately half of patients diagnosed with oesophageal cancer have metastatic or unresectable disease. Here, the authors discuss the multidisciplinary interventions available to manage dysphagia, improve quality of life and prolong survival in these individuals.
Abstract | Full Text | PDF

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